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Q48HN1

- GCH4_PSE14

UniProt

Q48HN1 - GCH4_PSE14

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-2923-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:PSPPH_2920
OrganismiPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000551: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301GTP cyclohydrolase FolE2PRO_0000289511Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264730.PSPPH_2920.

Structurei

3D structure databases

ProteinModelPortaliQ48HN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiQNLMYVE.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48HN1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MNNPLPDVAL TEVSSALVSL DWVGMQGVEV PVRLAEAGVR YPVHAHVDLQ
60 70 80 90 100
VDLADPSVKG IHMSRLYRLL DRYAEHQILS PDTLGALLEA MVESHLDCHS
110 120 130 140 150
SRARLTLSFN LLCRRPALIT EGLSGWKSYP VKLDATWHAG RLCLDVSADI
160 170 180 190 200
TYSSTCPCSA ALSRQLLEGA FTARFGRQSF VDPMQVATWL RENASFATPH
210 220 230 240 250
SQRSVATVQV RVAEQATELG LMTLIDAVEQ ALGTPVQTAV KRADEQAFAR
260 270 280 290 300
LNGQNLMYVE DAARKVQQAL EGRYAASSVS VRHFESLHPH DAAAQTSNYL

S
Length:301
Mass (Da):32,977
Last modified:September 13, 2005 - v1
Checksum:iCE1ED3975FF7C27E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000058 Genomic DNA. Translation: AAZ37560.1.
RefSeqiYP_275102.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ37560; AAZ37560; PSPPH_2920.
GeneIDi3560219.
KEGGipsp:PSPPH_2920.
PATRICi19975174. VBIPseSyr78478_3069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000058 Genomic DNA. Translation: AAZ37560.1 .
RefSeqi YP_275102.1. NC_005773.3.

3D structure databases

ProteinModelPortali Q48HN1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264730.PSPPH_2920.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ37560 ; AAZ37560 ; PSPPH_2920 .
GeneIDi 3560219.
KEGGi psp:PSPPH_2920.
PATRICi 19975174. VBIPseSyr78478_3069.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi QNLMYVE.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci PSAV264730:GKDE-2923-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1448A / Race 6.

Entry informationi

Entry nameiGCH4_PSE14
AccessioniPrimary (citable) accession number: Q48HN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3