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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE), GTP cyclohydrolase 1 (folE), GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei156May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:PSPPH_2920
OrganismiPseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000551 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002895111 – 301GTP cyclohydrolase FolE2Add BLAST301

Interactioni

Protein-protein interaction databases

STRINGi264730.PSPPH_2920

Structurei

3D structure databases

ProteinModelPortaliQ48HN1
SMRiQ48HN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000247517
KOiK09007
OMAiPYSSTCP

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q48HN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNPLPDVAL TEVSSALVSL DWVGMQGVEV PVRLAEAGVR YPVHAHVDLQ
60 70 80 90 100
VDLADPSVKG IHMSRLYRLL DRYAEHQILS PDTLGALLEA MVESHLDCHS
110 120 130 140 150
SRARLTLSFN LLCRRPALIT EGLSGWKSYP VKLDATWHAG RLCLDVSADI
160 170 180 190 200
TYSSTCPCSA ALSRQLLEGA FTARFGRQSF VDPMQVATWL RENASFATPH
210 220 230 240 250
SQRSVATVQV RVAEQATELG LMTLIDAVEQ ALGTPVQTAV KRADEQAFAR
260 270 280 290 300
LNGQNLMYVE DAARKVQQAL EGRYAASSVS VRHFESLHPH DAAAQTSNYL

S
Length:301
Mass (Da):32,977
Last modified:September 13, 2005 - v1
Checksum:iCE1ED3975FF7C27E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA Translation: AAZ37560.1
RefSeqiWP_011168867.1, NC_005773.3

Genome annotation databases

EnsemblBacteriaiAAZ37560; AAZ37560; PSPPH_2920
KEGGipsp:PSPPH_2920

Similar proteinsi

Entry informationi

Entry nameiGCH4_PSE14
AccessioniPrimary (citable) accession number: Q48HN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health