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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei156 – 1561May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-2923-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:PSPPH_2920
OrganismiPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000551: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301GTP cyclohydrolase FolE2PRO_0000289511Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264730.PSPPH_2920.

Structurei

3D structure databases

ProteinModelPortaliQ48HN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiQNLMYVE.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48HN1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNPLPDVAL TEVSSALVSL DWVGMQGVEV PVRLAEAGVR YPVHAHVDLQ
60 70 80 90 100
VDLADPSVKG IHMSRLYRLL DRYAEHQILS PDTLGALLEA MVESHLDCHS
110 120 130 140 150
SRARLTLSFN LLCRRPALIT EGLSGWKSYP VKLDATWHAG RLCLDVSADI
160 170 180 190 200
TYSSTCPCSA ALSRQLLEGA FTARFGRQSF VDPMQVATWL RENASFATPH
210 220 230 240 250
SQRSVATVQV RVAEQATELG LMTLIDAVEQ ALGTPVQTAV KRADEQAFAR
260 270 280 290 300
LNGQNLMYVE DAARKVQQAL EGRYAASSVS VRHFESLHPH DAAAQTSNYL

S
Length:301
Mass (Da):32,977
Last modified:September 13, 2005 - v1
Checksum:iCE1ED3975FF7C27E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ37560.1.
RefSeqiWP_011168867.1. NC_005773.3.
YP_275102.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ37560; AAZ37560; PSPPH_2920.
GeneIDi3560219.
KEGGipsp:PSPPH_2920.
PATRICi19975174. VBIPseSyr78478_3069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ37560.1.
RefSeqiWP_011168867.1. NC_005773.3.
YP_275102.1. NC_005773.3.

3D structure databases

ProteinModelPortaliQ48HN1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264730.PSPPH_2920.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ37560; AAZ37560; PSPPH_2920.
GeneIDi3560219.
KEGGipsp:PSPPH_2920.
PATRICi19975174. VBIPseSyr78478_3069.

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiQNLMYVE.
OrthoDBiEOG6X6RBH.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.
BioCyciPSAV264730:GKDE-2923-MONOMER.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1448A / Race 6.

Entry informationi

Entry nameiGCH4_PSE14
AccessioniPrimary (citable) accession number: Q48HN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: September 13, 2005
Last modified: January 7, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.