Q48GY3 (IOLG_PSE14) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	PSPPH_3188

Organism

Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6) [Complete proteome] [HAMAP]

Taxonomic identifier

264730 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas syringae pv. savastanoi

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.
Sequence caution	The sequence AAZ36345.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352581

Sequences

	Sequence		Length	Mass (Da)
	Q48GY3 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: 05F3A723614BE70C	FASTA	336	36,554
	10 20 30 40 50 60 MALKLGVIGT GAIGQDHIRR CSKTLVGSQV VAVTDINLEQ AAKVVRELDI GAEVYADGHA 70 80 90 100 110 120 LIAAPDVEAV LVCSWGPSHE EYVLAAIAAG KPVFCEKPLA VTAEGCRHIV EAEIASGRRL 130 140 150 160 170 180 VQVGFMRPYD QGYRALKSVI DSGRIGEPLM LHCAHRNPRV GENYKTDMAI TDTLIHELNV 190 200 210 220 230 240 LRWLLNDDYV SVQVVFPRKT SKALAHMKDP QIVMLETARG TRIDVEVFVN CQYGYDIQCE 250 260 270 280 290 300 VVGESGIAKL PEPSQVQLRS EAKLSNAILM DWKDRFIAAY DVELQDFIDG VNAGTIYGPS 310 320 330 AWDGYAAAVA ADACVQAQNS GAVVPIALEM RPAFYD

References

[1]

"Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition." Joardar V., Lindeberg M., Jackson R.W., Selengut J., Dodson R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn Giglio M., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A., Crabtree J., Creasy T., Davidsen T.M., Haft D.H. , Zafar N., Zhou L., Halpin R., Holley T., Khouri H.M., Feldblyum T.V., White O., Fraser C.M., Chatterjee A.K., Cartinhour S., Schneider D., Mansfield J.W., Collmer A., Buell R. J. Bacteriol. 187:6488-6498(2005) [PubMed: 16159782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1448A / Race 6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000058 Genomic DNA. Translation: AAZ36345.1. Different initiation.
RefSeq	YP_275350.1. NC_005773.3.
3D structure databases
ProteinModelPortal	Q48GY3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q48GY3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3558962.
GenomeReviews	Gene locus PSPPH_3188 in contig CP000058_GR.
KEGG	psp:PSPPH_3188.
NMPDR	fig|264730.3.peg.3149.
PATRIC	19975762. VBIPseSyr78478_3353.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
ProtClustDB	CLSK2757149.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_PSE14

Accession

Primary (citable) accession number: Q48GY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	October 14, 2008
Last modified:	January 25, 2012
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program