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Q48GX0 (Q48GX0_PSE14) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair By similarity. HAMAP-Rule MF_00015

Catalytic activity

Hydrolysis of Ala-|-Gly bond in repressor lexA. RuleBase RU003992 HAMAP-Rule MF_00015 SAAS SAAS019759

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00015 SAAS SAAS019759

Sequence similarities

Belongs to the peptidase S24 family. RuleBase RU003991 HAMAP-Rule MF_00015

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

DNA binding28 – 4821H-T-H motif By similarity HAMAP-Rule MF_00015

Sites

Active site1231For autocatalytic cleavage activity By similarity HAMAP-Rule MF_00015
Active site1601For autocatalytic cleavage activity By similarity HAMAP-Rule MF_00015
Site88 – 892Cleavage; by autolysis By similarity HAMAP-Rule MF_00015

Sequences

Sequence LengthMass (Da)Tools
Q48GX0 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 48257AB73A3BB9B6

FASTA20222,150
        10         20         30         40         50         60 
MIKLTPRQAE ILGFIKRCLE DNGFPPTRAE IAQELGFKSP NAAEEHLKAL ARKGAIEMTP 

        70         80         90        100        110        120 
GASRGIRIPG FEARPDESSL PVIGRVAAGA PILAQQHIEE SCNINPSFFH PSANYLLRVH 

       130        140        150        160        170        180 
GMSMKDVGIL DGDLLAVHTT REARNGQIVV ARIGDEVTVK RFKREGSKVW LLAENPDFAP 

       190        200 
IEVDLKDQEL VIEGLSVGVI RR

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References

[1]"Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition."
Joardar V., Lindeberg M., Jackson R.W., Selengut J., Dodson R., Brinkac L.M., Daugherty S.C., Deboy R., Durkin A.S., Giglio M.G., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S., Crabtree J., Creasy T., Davidsen T., Haft D.H. expand/collapse author list , Zafar N., Zhou L., Halpin R., Holley T., Khouri H., Feldblyum T., White O., Fraser C.M., Chatterjee A.K., Cartinhour S., Schneider D.J., Mansfield J., Collmer A., Buell C.R.
J. Bacteriol. 187:6488-6498(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1448A / Race 6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000058 Genomic DNA. Translation: AAZ34816.1.
RefSeqYP_275363.1. NC_005773.3.

3D structure databases

ProteinModelPortalQ48GX0.
SMRQ48GX0. Positions 4-201.
ModBaseSearch...

Protein-protein interaction databases

STRING264730.PSPPH_3203.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ34816; AAZ34816; PSPPH_3203.
GeneID3557378.
KEGGpsp:PSPPH_3203.
PATRIC19975796. VBIPseSyr78478_3370.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1974.
HOGENOMHOG000232167.
KOK01356.
OMARGDSMKN.
ProtClustDBPRK00215.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.10.109.10. 1 hit.
HAMAPMF_00015. LexA.
InterProIPR006199. LexA_DNA-bd_dom.
IPR006200. Pept_S24_LexA.
IPR006197. Peptidase_S24_LexA.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR011056. Peptidase_S24_S26A/B/C_b-rbn.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF01726. LexA_DNA_bind. 1 hit.
PF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSPR00726. LEXASERPTASE.
SUPFAMSSF51306. Pept_S24_S26_C. 1 hit.
TIGRFAMsTIGR00498. lexA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ48GX0_PSE14
AccessionPrimary (citable) accession number: Q48GX0
Entry history
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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