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Q48GS7

- HGD_PSE14

UniProt

Q48GS7 - HGD_PSE14

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Protein
Homogentisate 1,2-dioxygenase
Gene
hmgA, PSPPH_3246
Organism
Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate By similarity.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Iron By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei289 – 2891Proton acceptor By similarity
Metal bindingi332 – 3321Iron By similarity
Metal bindingi338 – 3381Iron By similarity
Binding sitei347 – 3471homogentisate By similarity
Metal bindingi368 – 3681Iron By similarity
Binding sitei368 – 3681homogentisate By similarity

GO - Molecular functioni

  1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
  2. tyrosine catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-3249-MONOMER.
UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenase (EC:1.13.11.5)
Short name:
HGDO
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene namesi
Name:hmgA
Ordered Locus Names:PSPPH_3246
OrganismiPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000551: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Homogentisate 1,2-dioxygenaseUniRule annotation
PRO_0000225793Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi264730.PSPPH_3246.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
KOiK00451.
OMAiRCFYNSD.
OrthoDBiEOG6D5FZK.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48GS7-1 [UniParc]FASTAAdd to Basket

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MAIHSRSDAL AYQSGFGNQF SSEALPGALP IGQNSPQKHP LGLYAEQFSG    50
TAFTVARSEA RRTWLYRIKP SAAHPRYQRM GRQIAGQEQG PINPNRLRWN 100
AFDIPAEPVD FIDGLIPLAS TSAADQADGV SVYVYAANTS MQRAFFSADG 150
EWLIVPQQGR LRIITELGLL DIEPLEIAVL PRGMKFRVQL LDSSARGYIC 200
ENHGCALRLP ELGPIGSNGL ANPRDFLTPV AWFEDNQQPV ELVQKFLGEL 250
WSTHLEHSPF DVVGWHGNNV AYKYDLRRFN TIGTVSYDHP DPSIFTVLTS 300
PGAAHGQANI DFVIFPPRWM VAENTFRPPW FHRNLMNEFM GLIDGAYDAK 350
AEGFMPGGAS LHNCMSAHGP DNVTAEKAIA AELKPHKIEN TMAFMFETGK 400
VLRPSRHALG CPQLQADYDA CWNDMTRTFN KEPRR 435
Length:435
Mass (Da):48,438
Last modified:September 13, 2005 - v1
Checksum:i780C40AF83FC95C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000058 Genomic DNA. Translation: AAZ36498.1.
RefSeqiYP_275406.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ36498; AAZ36498; PSPPH_3246.
GeneIDi3559119.
KEGGipsp:PSPPH_3246.
PATRICi19975884. VBIPseSyr78478_3414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000058 Genomic DNA. Translation: AAZ36498.1 .
RefSeqi YP_275406.1. NC_005773.3.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264730.PSPPH_3246.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ36498 ; AAZ36498 ; PSPPH_3246 .
GeneIDi 3559119.
KEGGi psp:PSPPH_3246.
PATRICi 19975884. VBIPseSyr78478_3414.

Phylogenomic databases

eggNOGi COG3508.
HOGENOMi HOG000139824.
KOi K00451.
OMAi RCFYNSD.
OrthoDBi EOG6D5FZK.

Enzyme and pathway databases

UniPathwayi UPA00139 ; UER00339 .
BioCyci PSAV264730:GKDE-3249-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00334. Homogentis_dioxygen.
InterProi IPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR11056. PTHR11056. 1 hit.
Pfami PF04209. HgmA. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR01015. hmgA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1448A / Race 6.

Entry informationi

Entry nameiHGD_PSE14
AccessioniPrimary (citable) accession number: Q48GS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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