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Q48FM7 (Q48FM7_PSE14) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length928 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP-Rule MF_01897

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1221O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q48FM7 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: C303F9C5CA7949D9

FASTA928102,563
        10         20         30         40         50         60 
MGELAKEILP VNIEDELKQS YLDYAMSVIV GRALPDARDG LKPVHRRVLF AMSELGNDWN 

        70         80         90        100        110        120 
KPYKKSARVV GDVIGKYHPH GDIAVYDTIV RMAQPFSLRY LLVDGQGNFG SVDGDNAAAM 

       130        140        150        160        170        180 
RYTEVRMTKL AHELLADLHK ETVDWVPNYD GTEMIPAVMP TRIPNLLVNG SSGIAVGMAT 

       190        200        210        220        230        240 
NIPPHNLGEV IDGCLALIDN PELTIDELMQ YIPGPDFPTA AIINGRAGII EAYRTGRGRI 

       250        260        270        280        290        300 
YMRARSIVED IDKVGGRQQI VITELPYQLN KARLIEKIAE LVKEKKLEGI TELRDESDKD 

       310        320        330        340        350        360 
GMRVVIELRR GEVPEVVLNN LYAQTQLQSV FGINIVALID GRPRILNLKD LLEAFVRHRR 

       370        380        390        400        410        420 
EVVTRRTVFE LRKARERGHI LEGQAVALSN IDPVIALIKA SPTPAEAKEA LIKTPWESSA 

       430        440        450        460        470        480 
VVEMVERAGA DSCRPENLDP QYGLREGKYF LSPEQAQAIL ELRLHRLTGL EHEKLLGEYQ 

       490        500        510        520        530        540 
EILNQIGELI RILNSATRLM EVIREELEVI RSEYGDARRT EILDARLDLT LGDLITEEER 

       550        560        570        580        590        600 
VVTISHGGYA KTQPLAVYQA QRRGGKGKSA TGIKDEDYIA HLLVANSHTT LLMFSSKGKV 

       610        620        630        640        650        660 
YWLKTYEIPE ASRAARGRPL VNLLPLSDGE YITTMLPVDL EAMRKRADEE GEALEGELDD 

       670        680        690        700        710        720 
AENSSETEEE RKACIKAADK KKAPFIFMST ANGTVKKTPL VAFSRQRSSG LIALELDEGD 

       730        740        750        760        770        780 
ILISAAITDG EQEIMLFSDG GKVTRFKESD VRAMGRTARG VRGMRLSEGQ KLISMLIPEE 

       790        800        810        820        830        840 
GSQILTASER GYGKRTAISE FPEYKRGGQG VIAMVSNERN GRLVGAVQVL DGEEIMLISD 

       850        860        870        880        890        900 
QGTLVRTRVG EVSSLGRNTQ GVTLIKLASD EKLVGLERVQ EPSEVEGEEL EGEEVIDGVI 

       910        920 
VDAAEAEVGD AGEDLQADAA PDEDEPQN 

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References

[1]"Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition."
Joardar V., Lindeberg M., Jackson R.W., Selengut J., Dodson R., Brinkac L.M., Daugherty S.C., Deboy R., Durkin A.S., Giglio M.G., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S., Crabtree J., Creasy T., Davidsen T., Haft D.H. expand/collapse author list , Zafar N., Zhou L., Halpin R., Holley T., Khouri H., Feldblyum T., White O., Fraser C.M., Chatterjee A.K., Cartinhour S., Schneider D.J., Mansfield J., Collmer A., Buell C.R.
J. Bacteriol. 187:6488-6498(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1448A / Race 6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000058 Genomic DNA. Translation: AAZ37312.1.
RefSeqYP_275809.1. NC_005773.3.

3D structure databases

ProteinModelPortalQ48FM7.
SMRQ48FM7. Positions 30-522.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264730.PSPPH_3667.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ37312; AAZ37312; PSPPH_3667.
GeneID3559959.
KEGGpsp:PSPPH_3667.
PATRIC19976762. VBIPseSyr78478_3845.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAETVDWVP.
OrthoDBEOG661H5V.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycPSAV264730:GKDE-3670-MONOMER.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. SSF56719. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ48FM7_PSE14
AccessionPrimary (citable) accession number: Q48FM7
Entry history
Integrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)