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Q48F72

- LPXB_PSE14

UniProt

Q48F72 - LPXB_PSE14

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-3830-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:PSPPH_3827
OrganismiPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000551: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Lipid-A-disaccharide synthasePRO_0000255209Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264730.PSPPH_3827.

Structurei

3D structure databases

ProteinModelPortaliQ48F72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48F72-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKPLCIALV AGEASGDILG SGLMRALKVR HPDIRFIGVG GPLMEAEGMQ
60 70 80 90 100
SYFPMERLSV MGLVEVLGRL RELLARRKLL VQTLINEKPD VFIGIDAPDF
110 120 130 140 150
TLNIELQLRR AGIKTVHYVS PSVWAWRQKR VLKIREGCDL MLTLLPFEAR
160 170 180 190 200
FYEEKGVPVR FVGHPLADTI PLESYRAAAR AGLGLAQEAP VVALMPGSRG
210 220 230 240 250
GEVGRLGGLF FDAAELLLAQ RPGLRFVLPC ASPQRRAQVE QLLQGRNLPV
260 270 280 290 300
TLLDGQSHVA LAACDAVLIA SGTATLEALL YKRPMVVAYR LAPLTFWILK
310 320 330 340 350
RMVKSPYVSL PNLLAQRLLV PELLQDDATP EALARTLLPL IDDGQAQTAG
360 370 380
FDAIHRILRR DASNQAADAV LSLLGQSSSQ
Length:380
Mass (Da):41,514
Last modified:September 13, 2005 - v1
Checksum:iD665BBD7E4AC0A17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ37276.1.
RefSeqiWP_011169291.1. NC_005773.3.
YP_275965.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ37276; AAZ37276; PSPPH_3827.
GeneIDi3559921.
KEGGipsp:PSPPH_3827.
PATRICi19977093. VBIPseSyr78478_4007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ37276.1 .
RefSeqi WP_011169291.1. NC_005773.3.
YP_275965.1. NC_005773.3.

3D structure databases

ProteinModelPortali Q48F72.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264730.PSPPH_3827.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ37276 ; AAZ37276 ; PSPPH_3827 .
GeneIDi 3559921.
KEGGi psp:PSPPH_3827.
PATRICi 19977093. VBIPseSyr78478_4007.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PSAV264730:GKDE-3830-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1448A / Race 6.

Entry informationi

Entry nameiLPXB_PSE14
AccessioniPrimary (citable) accession number: Q48F72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3