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Q48F65

- DXR_PSE14

UniProt

Q48F65 - DXR_PSE14

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Protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Gene
dxr, PSPPH_3834
Organism
Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity.UniRule annotation

Catalytic activityi

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotation

Cofactori

Divalent cation By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei128 – 1281Substrate By similarity
Metal bindingi153 – 1531Divalent metal cation By similarity
Metal bindingi155 – 1551Divalent metal cation By similarity
Binding sitei155 – 1551Substrate By similarity
Binding sitei184 – 1841Substrate By similarity
Binding sitei207 – 2071Substrate By similarity
Metal bindingi229 – 2291Divalent metal cation By similarity
Binding sitei229 – 2291Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 3930NADP By similarity
Add
BLAST

GO - Molecular functioni

  1. 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Source: UniProtKB-HAMAP
  2. NADPH binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

Metal-binding, NADP

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-3837-MONOMER.
UniPathwayiUPA00056; UER00092.

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC:1.1.1.267)
Short name:
DXP reductoisomerase
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase
2-C-methyl-D-erythritol 4-phosphate synthase
Gene namesi
Name:dxr
Ordered Locus Names:PSPPH_3834
OrganismiPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000551: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3963961-deoxy-D-xylulose 5-phosphate reductoisomeraseUniRule annotation
PRO_0000163699Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264730.PSPPH_3834.

Structurei

3D structure databases

ProteinModelPortaliQ48F65.
SMRiQ48F65. Positions 5-395.

Family & Domainsi

Sequence similaritiesi

Belongs to the DXR family.

Phylogenomic databases

eggNOGiCOG0743.
HOGENOMiHOG000007221.
KOiK00099.
OMAiDYARYPC.
OrthoDBiEOG6R2H04.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00183. DXP_reductoisom.
InterProiIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR30525. PTHR30525. 1 hit.
PfamiPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMiSSF69055. SSF69055. 1 hit.
TIGRFAMsiTIGR00243. Dxr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48F65-1 [UniParc]FASTAAdd to Basket

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MSGPQHITIL GATGSIGLST LDVVARHPSR YQVFALTGFS RLDELLALCV    50
RHTPQYAVVP DQFVARKLQD DLAAAVLDTR VLVGEGGLCE VAAHPRVDAV 100
MAAIVGAAGL RPTLAAVEAG KKVLLANKEA LVMSGDLFMQ AVRQSGAVLL 150
PIDSEHNAIF QCLPGDFARG LGAVGVRRIM LTASGGPFRE TPLEQLQNVT 200
PEQACAHPVW SMGRKISVDS ATMMNKGLEL IEACWLFDAR PDQVEVVIHP 250
QSVIHSLVDY VDGSVLAQLG NPDMRTPIAN ALAWPARVDS GVAPLDLFRI 300
GQLDFQKPDE ERFPCLRLAR HAAEAGGSAP AMLNAANEVA VAAFLDGRIR 350
YLEIAGIIEE VLNHEPVTAV EGLDAVFAAD AKARLLAGQW LERNAR 396
Length:396
Mass (Da):42,342
Last modified:September 13, 2005 - v1
Checksum:iB62688A0E2E36A97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000058 Genomic DNA. Translation: AAZ37105.1.
RefSeqiYP_275972.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ37105; AAZ37105; PSPPH_3834.
GeneIDi3559744.
KEGGipsp:PSPPH_3834.
PATRICi19977109. VBIPseSyr78478_4015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000058 Genomic DNA. Translation: AAZ37105.1 .
RefSeqi YP_275972.1. NC_005773.3.

3D structure databases

ProteinModelPortali Q48F65.
SMRi Q48F65. Positions 5-395.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264730.PSPPH_3834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ37105 ; AAZ37105 ; PSPPH_3834 .
GeneIDi 3559744.
KEGGi psp:PSPPH_3834.
PATRICi 19977109. VBIPseSyr78478_4015.

Phylogenomic databases

eggNOGi COG0743.
HOGENOMi HOG000007221.
KOi K00099.
OMAi DYARYPC.
OrthoDBi EOG6R2H04.

Enzyme and pathway databases

UniPathwayi UPA00056 ; UER00092 .
BioCyci PSAV264730:GKDE-3837-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00183. DXP_reductoisom.
InterProi IPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR30525. PTHR30525. 1 hit.
Pfami PF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMi SSF69055. SSF69055. 1 hit.
TIGRFAMsi TIGR00243. Dxr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1448A / Race 6.

Entry informationi

Entry nameiDXR_PSE14
AccessioniPrimary (citable) accession number: Q48F65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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