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Q48F65

- DXR_PSE14

UniProt

Q48F65 - DXR_PSE14

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Protein

1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene

dxr

Organism
Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).UniRule annotation

Catalytic activityi

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei128 – 1281SubstrateUniRule annotation
Metal bindingi153 – 1531Divalent metal cationUniRule annotation
Metal bindingi155 – 1551Divalent metal cationUniRule annotation
Binding sitei155 – 1551SubstrateUniRule annotation
Binding sitei184 – 1841SubstrateUniRule annotation
Binding sitei207 – 2071SubstrateUniRule annotation
Metal bindingi229 – 2291Divalent metal cationUniRule annotation
Binding sitei229 – 2291SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 3930NADPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. NADPH binding Source: InterPro

GO - Biological processi

  1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

Metal-binding, NADP

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-3837-MONOMER.
UniPathwayiUPA00056; UER00092.

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomeraseUniRule annotation (EC:1.1.1.267UniRule annotation)
Short name:
DXP reductoisomeraseUniRule annotation
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomeraseUniRule annotation
2-C-methyl-D-erythritol 4-phosphate synthaseUniRule annotation
Gene namesi
Name:dxrUniRule annotation
Ordered Locus Names:PSPPH_3834
OrganismiPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000551: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3963961-deoxy-D-xylulose 5-phosphate reductoisomerasePRO_0000163699Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264730.PSPPH_3834.

Structurei

3D structure databases

ProteinModelPortaliQ48F65.
SMRiQ48F65. Positions 5-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DXR family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0743.
HOGENOMiHOG000007221.
KOiK00099.
OMAiDYARYPC.
OrthoDBiEOG6R2H04.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00183. DXP_reductoisom.
InterProiIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR30525. PTHR30525. 1 hit.
PfamiPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMiSSF69055. SSF69055. 1 hit.
TIGRFAMsiTIGR00243. Dxr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48F65-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGPQHITIL GATGSIGLST LDVVARHPSR YQVFALTGFS RLDELLALCV
60 70 80 90 100
RHTPQYAVVP DQFVARKLQD DLAAAVLDTR VLVGEGGLCE VAAHPRVDAV
110 120 130 140 150
MAAIVGAAGL RPTLAAVEAG KKVLLANKEA LVMSGDLFMQ AVRQSGAVLL
160 170 180 190 200
PIDSEHNAIF QCLPGDFARG LGAVGVRRIM LTASGGPFRE TPLEQLQNVT
210 220 230 240 250
PEQACAHPVW SMGRKISVDS ATMMNKGLEL IEACWLFDAR PDQVEVVIHP
260 270 280 290 300
QSVIHSLVDY VDGSVLAQLG NPDMRTPIAN ALAWPARVDS GVAPLDLFRI
310 320 330 340 350
GQLDFQKPDE ERFPCLRLAR HAAEAGGSAP AMLNAANEVA VAAFLDGRIR
360 370 380 390
YLEIAGIIEE VLNHEPVTAV EGLDAVFAAD AKARLLAGQW LERNAR
Length:396
Mass (Da):42,342
Last modified:September 13, 2005 - v1
Checksum:iB62688A0E2E36A97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ37105.1.
RefSeqiYP_275972.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ37105; AAZ37105; PSPPH_3834.
GeneIDi3559744.
KEGGipsp:PSPPH_3834.
PATRICi19977109. VBIPseSyr78478_4015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ37105.1 .
RefSeqi YP_275972.1. NC_005773.3.

3D structure databases

ProteinModelPortali Q48F65.
SMRi Q48F65. Positions 5-395.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264730.PSPPH_3834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ37105 ; AAZ37105 ; PSPPH_3834 .
GeneIDi 3559744.
KEGGi psp:PSPPH_3834.
PATRICi 19977109. VBIPseSyr78478_4015.

Phylogenomic databases

eggNOGi COG0743.
HOGENOMi HOG000007221.
KOi K00099.
OMAi DYARYPC.
OrthoDBi EOG6R2H04.

Enzyme and pathway databases

UniPathwayi UPA00056 ; UER00092 .
BioCyci PSAV264730:GKDE-3837-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00183. DXP_reductoisom.
InterProi IPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR30525. PTHR30525. 1 hit.
Pfami PF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMi SSF69055. SSF69055. 1 hit.
TIGRFAMsi TIGR00243. Dxr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1448A / Race 6.

Entry informationi

Entry nameiDXR_PSE14
AccessioniPrimary (citable) accession number: Q48F65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3