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Q48F65

- DXR_PSE14

UniProt

Q48F65 - DXR_PSE14

Protein

1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene

dxr

Organism
Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).UniRule annotation

    Catalytic activityi

    2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotation

    Cofactori

    Divalent cation.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei128 – 1281SubstrateUniRule annotation
    Metal bindingi153 – 1531Divalent metal cationUniRule annotation
    Metal bindingi155 – 1551Divalent metal cationUniRule annotation
    Binding sitei155 – 1551SubstrateUniRule annotation
    Binding sitei184 – 1841SubstrateUniRule annotation
    Binding sitei207 – 2071SubstrateUniRule annotation
    Metal bindingi229 – 2291Divalent metal cationUniRule annotation
    Binding sitei229 – 2291SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 3930NADPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. NADPH binding Source: InterPro

    GO - Biological processi

    1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Isoprene biosynthesis

    Keywords - Ligandi

    Metal-binding, NADP

    Enzyme and pathway databases

    BioCyciPSAV264730:GKDE-3837-MONOMER.
    UniPathwayiUPA00056; UER00092.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-deoxy-D-xylulose 5-phosphate reductoisomeraseUniRule annotation (EC:1.1.1.267UniRule annotation)
    Short name:
    DXP reductoisomeraseUniRule annotation
    Alternative name(s):
    1-deoxyxylulose-5-phosphate reductoisomeraseUniRule annotation
    2-C-methyl-D-erythritol 4-phosphate synthaseUniRule annotation
    Gene namesi
    Name:dxrUniRule annotation
    Ordered Locus Names:PSPPH_3834
    OrganismiPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
    Taxonomic identifieri264730 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000551: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3963961-deoxy-D-xylulose 5-phosphate reductoisomerasePRO_0000163699Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264730.PSPPH_3834.

    Structurei

    3D structure databases

    ProteinModelPortaliQ48F65.
    SMRiQ48F65. Positions 5-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DXR family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0743.
    HOGENOMiHOG000007221.
    KOiK00099.
    OMAiDYARYPC.
    OrthoDBiEOG6R2H04.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00183. DXP_reductoisom.
    InterProiIPR003821. DXP_reductoisomerase.
    IPR013644. DXP_reductoisomerase_C.
    IPR013512. DXP_reductoisomerase_N.
    IPR026877. DXPR_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR30525. PTHR30525. 1 hit.
    PfamiPF08436. DXP_redisom_C. 1 hit.
    PF02670. DXP_reductoisom. 1 hit.
    PF13288. DXPR_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006205. Dxp_reductismrs. 1 hit.
    SUPFAMiSSF69055. SSF69055. 1 hit.
    TIGRFAMsiTIGR00243. Dxr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q48F65-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGPQHITIL GATGSIGLST LDVVARHPSR YQVFALTGFS RLDELLALCV    50
    RHTPQYAVVP DQFVARKLQD DLAAAVLDTR VLVGEGGLCE VAAHPRVDAV 100
    MAAIVGAAGL RPTLAAVEAG KKVLLANKEA LVMSGDLFMQ AVRQSGAVLL 150
    PIDSEHNAIF QCLPGDFARG LGAVGVRRIM LTASGGPFRE TPLEQLQNVT 200
    PEQACAHPVW SMGRKISVDS ATMMNKGLEL IEACWLFDAR PDQVEVVIHP 250
    QSVIHSLVDY VDGSVLAQLG NPDMRTPIAN ALAWPARVDS GVAPLDLFRI 300
    GQLDFQKPDE ERFPCLRLAR HAAEAGGSAP AMLNAANEVA VAAFLDGRIR 350
    YLEIAGIIEE VLNHEPVTAV EGLDAVFAAD AKARLLAGQW LERNAR 396
    Length:396
    Mass (Da):42,342
    Last modified:September 13, 2005 - v1
    Checksum:iB62688A0E2E36A97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000058 Genomic DNA. Translation: AAZ37105.1.
    RefSeqiYP_275972.1. NC_005773.3.

    Genome annotation databases

    EnsemblBacteriaiAAZ37105; AAZ37105; PSPPH_3834.
    GeneIDi3559744.
    KEGGipsp:PSPPH_3834.
    PATRICi19977109. VBIPseSyr78478_4015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000058 Genomic DNA. Translation: AAZ37105.1 .
    RefSeqi YP_275972.1. NC_005773.3.

    3D structure databases

    ProteinModelPortali Q48F65.
    SMRi Q48F65. Positions 5-395.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264730.PSPPH_3834.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ37105 ; AAZ37105 ; PSPPH_3834 .
    GeneIDi 3559744.
    KEGGi psp:PSPPH_3834.
    PATRICi 19977109. VBIPseSyr78478_4015.

    Phylogenomic databases

    eggNOGi COG0743.
    HOGENOMi HOG000007221.
    KOi K00099.
    OMAi DYARYPC.
    OrthoDBi EOG6R2H04.

    Enzyme and pathway databases

    UniPathwayi UPA00056 ; UER00092 .
    BioCyci PSAV264730:GKDE-3837-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00183. DXP_reductoisom.
    InterProi IPR003821. DXP_reductoisomerase.
    IPR013644. DXP_reductoisomerase_C.
    IPR013512. DXP_reductoisomerase_N.
    IPR026877. DXPR_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR30525. PTHR30525. 1 hit.
    Pfami PF08436. DXP_redisom_C. 1 hit.
    PF02670. DXP_reductoisom. 1 hit.
    PF13288. DXPR_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006205. Dxp_reductismrs. 1 hit.
    SUPFAMi SSF69055. SSF69055. 1 hit.
    TIGRFAMsi TIGR00243. Dxr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1448A / Race 6.

    Entry informationi

    Entry nameiDXR_PSE14
    AccessioniPrimary (citable) accession number: Q48F65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3