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Q48EC9

- HISX_PSE14

UniProt

Q48EC9 - HISX_PSE14

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei136 – 1361NADUniRule annotation
    Binding sitei197 – 1971NADUniRule annotation
    Binding sitei220 – 2201NADUniRule annotation
    Binding sitei243 – 2431SubstrateUniRule annotation
    Metal bindingi265 – 2651ZincUniRule annotation
    Binding sitei265 – 2651SubstrateUniRule annotation
    Metal bindingi268 – 2681ZincUniRule annotation
    Binding sitei268 – 2681SubstrateUniRule annotation
    Active sitei333 – 3331Proton acceptorUniRule annotation
    Active sitei334 – 3341Proton acceptorUniRule annotation
    Binding sitei334 – 3341SubstrateUniRule annotation
    Metal bindingi367 – 3671ZincUniRule annotation
    Binding sitei367 – 3671SubstrateUniRule annotation
    Binding sitei421 – 4211SubstrateUniRule annotation
    Metal bindingi426 – 4261ZincUniRule annotation
    Binding sitei426 – 4261SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciPSAV264730:GKDE-4141-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:PSPPH_4137
    OrganismiPseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
    Taxonomic identifieri264730 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000551: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Histidinol dehydrogenasePRO_0000135822Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264730.PSPPH_4137.

    Structurei

    3D structure databases

    ProteinModelPortaliQ48EC9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q48EC9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTPTAIRRL DAADPDFARH LDHLLSWESV SDDSVNQRVL DIIKAVRERG    50
    DEALVEFTQK FDGLQVASMA DLILPRERLE LALTRITPVQ REALEKAAER 100
    VRSYHEKQKQ DSWSYTEADG TVLGQKVTPL DRAGLYVPGG KASYPSSVLM 150
    NAIPAKVAGV TEVVMVVPTP RGEINELVLA AACIAGVDRV FTIGGAQAVA 200
    ALAYGTESVP KVDKVVGPGN IYVATAKRHV FGQVGIDMIA GPSEILVVCD 250
    GQTDPDWIAM DLFSQAEHDE DAQAILVSPD ADFLDKVAAS ITRLLPTMER 300
    AAIVETSING RGALIKVADM AQAIEVANRI APEHLELSVA DPEAWLPQIR 350
    HAGAIFMGRH TSEALGDYCA GPNHVLPTSG TARFSSPLGV YDFQKRSSII 400
    YCSPQGASEL GKTASVLARG ESLSGHARSA EYRITDPDWK AGNTEDGK 448
    Length:448
    Mass (Da):48,160
    Last modified:September 13, 2005 - v1
    Checksum:iD44110537C039678
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000058 Genomic DNA. Translation: AAZ37769.1.
    RefSeqiYP_276259.1. NC_005773.3.

    Genome annotation databases

    EnsemblBacteriaiAAZ37769; AAZ37769; PSPPH_4137.
    GeneIDi3560434.
    KEGGipsp:PSPPH_4137.
    PATRICi19977743. VBIPseSyr78478_4329.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000058 Genomic DNA. Translation: AAZ37769.1 .
    RefSeqi YP_276259.1. NC_005773.3.

    3D structure databases

    ProteinModelPortali Q48EC9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264730.PSPPH_4137.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ37769 ; AAZ37769 ; PSPPH_4137 .
    GeneIDi 3560434.
    KEGGi psp:PSPPH_4137.
    PATRICi 19977743. VBIPseSyr78478_4329.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci PSAV264730:GKDE-4141-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1448A / Race 6.

    Entry informationi

    Entry nameiHISX_PSE14
    AccessioniPrimary (citable) accession number: Q48EC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3