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Protein

Catalase-peroxidase

Gene

katG

Organism
Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei88 – 881Transition state stabilizerUniRule annotation
Active sitei92 – 921Proton acceptorUniRule annotation
Metal bindingi285 – 2851Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-4233-MONOMER.

Protein family/group databases

PeroxiBasei2310. PspCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:PSPPH_4229
OrganismiPseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000551 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 756756Catalase-peroxidasePRO_0000354871Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki91 ↔ 244Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-270)UniRule annotation
Cross-linki244 ↔ 270Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi264730.PSPPH_4229.

Structurei

3D structure databases

ProteinModelPortaliQ48E42.
SMRiQ48E42. Positions 16-756.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 3 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48E42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTESKCPFN HAAGGGTTNR DWWPKQLNLK ILHQHSSLSD PMGESFDYAK
60 70 80 90 100
EFKSLDFEAV KQDLRDVMTR SQDWWPADFG HYGPLFVRMA WHSAGTYRTG
110 120 130 140 150
DGHGGAGAGQ QRFAPLNSWP DNVSLDKARR LIWPVKQKYG RKISWADLIV
160 170 180 190 200
LTGNVALESM GFKTFGFSGG RPDVWEPEED VYWGSETTWL GGEERYGAQK
210 220 230 240 250
KMQQPGDGTL VAEPENHANE ESRTASGERN LENPLAAVQM GLIYVNPEGP
260 270 280 290 300
EGVPDPVASA KDIRETFGRM AMNDEETVAL IAGGHAFGKT HGAGPADNVG
310 320 330 340 350
PEPEAAGLEE QGLGWRNKFG SGKGGDTITS GLEVTWTSTP TKWSNEYLEN
360 370 380 390 400
LFGFEWELTK SPAGAHQWTP KNGAGAGKIP DAHDPSKRHA PSMLTSDLAL
410 420 430 440 450
RFDPAYEQIS RRFLNNPEQL ADAFARAWFK LTHRDMGPLA RYLGPETPAE
460 470 480 490 500
ELLWQDPIPN VDHALVDDQD VAALKGKILA SGLSVPQLVS TAWAAASTFR
510 520 530 540 550
GSDKRGGANG GRLRLAPQKD WAVNQPAQLA GVLKTLEGIQ SEFNAAQSSG
560 570 580 590 600
KQVSIADLIV LAGSAGVEQA AKNAGHHVTV PFTPGRADAS QEQTDVESFS
610 620 630 640 650
FLEPIADGFR NYQKGHYKVS AESLLVDKAQ LLTLTAPEMA VLLGGLRVLN
660 670 680 690 700
INVGQSKHGV FTDKPETLSN DFFKNLLDMG VEWRATSGAN DTFEARDRKT
710 720 730 740 750
GAVKWTGTRV DLVFGSHAQL RAISEVYGSS DANEKFVKDF VAAWTKVMNL

DRFDLA
Length:756
Mass (Da):82,463
Last modified:September 13, 2005 - v1
Checksum:i772DB7F942B4C55D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ34722.1.
RefSeqiWP_011169469.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ34722; AAZ34722; PSPPH_4229.
KEGGipsp:PSPPH_4229.
PATRICi19977929. VBIPseSyr78478_4421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ34722.1.
RefSeqiWP_011169469.1. NC_005773.3.

3D structure databases

ProteinModelPortaliQ48E42.
SMRiQ48E42. Positions 16-756.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264730.PSPPH_4229.

Protein family/group databases

PeroxiBasei2310. PspCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ34722; AAZ34722; PSPPH_4229.
KEGGipsp:PSPPH_4229.
PATRICi19977929. VBIPseSyr78478_4421.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciPSAV264730:GKDE-4233-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 3 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1448A / Race 6.

Entry informationi

Entry nameiKATG_PSE14
AccessioniPrimary (citable) accession number: Q48E42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: September 13, 2005
Last modified: July 6, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.