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Protein

Probable 5-dehydro-4-deoxyglucarate dehydratase

Gene

PSPPH_4252

Organism
Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5-dehydro-4-deoxy-D-glucarate = 2,5-dioxopentanoate + H2O + CO2.UniRule annotation

Pathwayi: D-glucarate degradation

This protein is involved in step 2 of the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable 5-dehydro-4-deoxyglucarate dehydratase (PSPPH_4252)
This subpathway is part of the pathway D-glucarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate, the pathway D-glucarate degradation and in Carbohydrate acid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

UniPathwayiUPA00564; UER00628.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-dehydro-4-deoxyglucarate dehydrataseUniRule annotation (EC:4.2.1.41UniRule annotation)
Alternative name(s):
5-keto-4-deoxy-glucarate dehydrataseUniRule annotation
Short name:
KDGDHUniRule annotation
Gene namesi
Ordered Locus Names:PSPPH_4252
OrganismiPseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) (Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6))
Taxonomic identifieri264730 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000551 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000454061 – 303Probable 5-dehydro-4-deoxyglucarate dehydrataseAdd BLAST303

Interactioni

Protein-protein interaction databases

STRINGi264730.PSPPH_4252.

Structurei

3D structure databases

ProteinModelPortaliQ48E20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DapA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105UVJ. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.

Family and domain databases

CDDicd00951. KDGDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03249. KdgD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48E20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPQELKSIL SSGLLSFPVT DFNAQGDFHR AGYIKRLEWL APYGASALFA
60 70 80 90 100
AGGTGEFFSL AASEYSEIIK TAVDTCATSV PILAGVGGPT RQAIEYAQEA
110 120 130 140 150
ERLGAKGLLL LPHYLTEASQ DGVAAHVEAV CKAVKIGVVV YNRNVCRLTP
160 170 180 190 200
TLLEQLAERC PNLIGYKDGL GDIELMVSIR RRLGDRFSYL GGLPTAEVYA
210 220 230 240 250
AAYKALGVPV YSSAVFNFVP KLAMDFYHAI ARDDHEAVGK YIDDFFLPYL
260 270 280 290 300
EIRNRKAGYA VSIVKAGAKI AGYDAGPVRA PLTDLTPDEC DMLAALMDKQ

GKQ
Length:303
Mass (Da):32,723
Last modified:September 13, 2005 - v1
Checksum:i3A26B0F50B1252C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ34628.1.
RefSeqiWP_004656752.1. NC_005773.3.

Genome annotation databases

EnsemblBacteriaiAAZ34628; AAZ34628; PSPPH_4252.
KEGGipsp:PSPPH_4252.
PATRICi19977981. VBIPseSyr78478_4447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000058 Genomic DNA. Translation: AAZ34628.1.
RefSeqiWP_004656752.1. NC_005773.3.

3D structure databases

ProteinModelPortaliQ48E20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264730.PSPPH_4252.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ34628; AAZ34628; PSPPH_4252.
KEGGipsp:PSPPH_4252.
PATRICi19977981. VBIPseSyr78478_4447.

Phylogenomic databases

eggNOGiENOG4105UVJ. Bacteria.
COG0329. LUCA.
HOGENOMiHOG000173605.
KOiK01707.
OMAiRNRKKGY.

Enzyme and pathway databases

UniPathwayiUPA00564; UER00628.

Family and domain databases

CDDicd00951. KDGDH. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00694. KDGDH. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR002220. DapA-like.
IPR017655. Dehydro-deoxyglucarate_dehyd.
[Graphical view]
PANTHERiPTHR12128. PTHR12128. 1 hit.
PfamiPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFiPIRSF001365. DHDPS. 1 hit.
SMARTiSM01130. DHDPS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03249. KdgD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKDGD_PSE14
AccessioniPrimary (citable) accession number: Q48E20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.