ID   ADD_PSE14               Reviewed;         317 AA.
AC   Q48D01;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Adenosine deaminase;
DE            EC=3.5.4.4;
DE   AltName: Full=Adenosine aminohydrolase;
GN   Name=add; OrderedLocusNames=PSPPH_4636;
OS   Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=264730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16159782; DOI=10.1128/JB.187.18.6488-6498.2005;
RA   Joardar V., Lindeberg M., Jackson R.W., Selengut J., Dodson R.,
RA   Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S.,
RA   Gwinn Giglio M., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A.,
RA   Crabtree J., Creasy T., Davidsen T.M., Haft D.H., Zafar N., Zhou L.,
RA   Halpin R., Holley T., Khouri H.M., Feldblyum T.V., White O.,
RA   Fraser C.M., Chatterjee A.K., Cartinhour S., Schneider D.,
RA   Mansfield J.W., Collmer A., Buell R.;
RT   "Whole-genome sequence analysis of Pseudomonas syringae pv.
RT   phaseolicola 1448A reveals divergence among pathovars in genes
RT   involved in virulence and transposition.";
RL   J. Bacteriol. 187:6488-6498(2005).
CC   -!- CATALYTIC ACTIVITY: Adenosine + H(2)O = inosine + NH(3).
CC   -!- SIMILARITY: Belongs to the adenosine and AMP deaminases family.
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DR   EMBL; CP000058; AAZ35126.1; -; Genomic_DNA.
DR   RefSeq; YP_276741.1; -.
DR   GeneID; 3557701; -.
DR   GenomeReviews; CP000058_GR; PSPPH_4636.
DR   KEGG; psp:PSPPH_4636; -.
DR   NMPDR; fig|264730.3.peg.4920; -.
DR   HOGENOM; Q48D01; -.
DR   OMA; Q48D01; LAQNSLD.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:HAMAP.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynt...; IEA:HAMAP.
DR   HAMAP; MF_00540; -; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A/AMP_deaminase.
DR   InterPro; IPR006330; A_deaminase.
DR   PANTHER; PTHR11409; A/AMP_deaminase; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   TIGRFAMs; TIGR01430; aden_deam; 1.
DR   PROSITE; PS00485; A_DEAMINASE; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Nucleotide metabolism.
FT   CHAIN         1    317       Adenosine deaminase.
FT                                /FTId=PRO_1000017676.
FT   ACT_SITE    194    194       Potential.
FT   ACT_SITE    242    242       Potential.
FT   ACT_SITE    275    275       Potential.
FT   ACT_SITE    276    276       Potential.
SQ   SEQUENCE   317 AA;  36102 MW;  114431C180569304 CRC64;
     MYDWLNALPK AELHLHLEGS LEPELLFALA ERNKIALPWN DVETLRKAYA FNNLQEFLDL
     YYRGADALRT EQDFYDLTWA YLLRCKEQNV IHTEPFFDPQ THTDRGIPFE VVLAGITGAL
     KDGKSKLGVD SGLILSFLRH LSQEEAEKTL DQALPFRDAF VAVGLDSSEM GHPPSKFQRV
     FDRARSEGFL TVAHAGEEGP PEYIWEALDL LKIQRIDHGV RAIEDERLMQ RIIDEQIPLT
     VCPLSNTKLC VFDDMAQHNI LDMLERGVKV TVNSDDPAYF GGYVTENFHA LYTHLGMTED
     QAKRLAQNSL DARLVKP
//