ID   DAPF_COLP3              Reviewed;         276 AA.
AC   Q48AR8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 21.
DE   RecName: Full=Diaminopimelate epimerase;
DE            Short=DAP epimerase;
DE            EC=5.1.1.7;
GN   Name=dapF; OrderedLocusNames=CPS_0077;
OS   Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio
OS   psychroerythus).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Colwelliaceae; Colwellia.
OX   NCBI_TaxID=167879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16043709; DOI=10.1073/pnas.0504766102;
RA   Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X.,
RA   Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M.,
RA   Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A.,
RA   Zhou L., Davidsen T.M., Wu M., Huston A.L., Lewis M., Weaver B.,
RA   Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M.;
RT   "The psychrophilic lifestyle as revealed by the genome sequence of
RT   Colwellia psychrerythraea 34H through genomic and proteomic
RT   analyses.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005).
CC   -!- CATALYTIC ACTIVITY: LL-2,6-diaminoheptanedioate = meso-
CC       diaminoheptanedioate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; DL-diaminopimelate from LL-diaminopimelate: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the diaminopimelate epimerase family.
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DR   EMBL; CP000083; AAZ24959.1; -; Genomic_DNA.
DR   RefSeq; YP_266845.1; -.
DR   GeneID; 3518496; -.
DR   GenomeReviews; CP000083_GR; CPS_0077.
DR   KEGG; cps:CPS_0077; -.
DR   NMPDR; fig|167879.3.peg.80; -.
DR   TIGR; CPS_0077; -.
DR   HOGENOM; Q48AR8; -.
DR   OMA; Q48AR8; PHAVLRV.
DR   BioCyc; CPSY167879:CPS_0077-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008837; F:diaminopimelate epimerase activity; IEA:HAMAP.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopime...; IEA:HAMAP.
DR   HAMAP; MF_00197; -; 1.
DR   InterPro; IPR001653; DAP_epimerase.
DR   InterPro; IPR018510; DAP_epimerase_CS.
DR   Pfam; PF01678; DAP_epimerase; 2.
DR   TIGRFAMs; TIGR00652; DapF; 1.
DR   PROSITE; PS01326; DAP_EPIMERASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; Isomerase;
KW   Lysine biosynthesis.
FT   CHAIN         1    276       Diaminopimelate epimerase.
FT                                /FTId=PRO_1000011871.
FT   ACT_SITE     75     75       By similarity.
FT   ACT_SITE    219    219       By similarity.
SQ   SEQUENCE   276 AA;  30230 MW;  AD258120101B30AC CRC64;
     MLVNFSKMHG LGNDFLVLDN VTQNVFLSPE QITKFANRNF GVGFDQLLVV EPPYDPDLDF
     HYRIYNADGS EVGQCGNGAR CFAKFVRMKG LCNKHKIKVS TSTGKMNLHI ERDGNISVTM
     PVPQFEPKKI PFTAQKTEGT YILRSESETV LCGAVSMGNP HCVVTVDSVA EADVESLGKE
     LSVHERFPED ANVGFMEIVS PNYIKLRVYE RGAAETLACG SGACAAVVIG YMQKKLAKQV
     TVELPGGKLR IFWQGPGHPV KMSGPATHVF DGQISI
//