Q48AM0 (UBIC_COLP3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable chorismate--pyruvate lyase
Short name=CL
Short name=CPL
EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	CPS_0125

Organism

Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]

Taxonomic identifier

167879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.
Sequence caution	The sequence AAZ28672.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Probable chorismate--pyruvate lyase HAMAP MF_01632		PRO_0000240543
Sites
	Binding site	86	1	Substrate By similarity
	Binding site	124	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q48AM0 [UniParc]. Last modified June 26, 2007. Version 2. Checksum: 8A01044A1C16F426	FASTA	206	22,746
	10 20 30 40 50 60 MKQQIVNFPI TFPITLSGQW QSPSAVSFSS LSTPLKDWLL DEGSLTARLK KHCDNFQVKV 70 80 90 100 110 120 IGEQQQPCSA AESCDLIKVG EPVLVREVIL YCDDVPQVFA RSLLPIASLT GEEQILANLG 130 140 150 160 170 180 EQPLGQVLFN NPSLQRLRLE LSPFVNDSSV VALAAKLTAQ HASNSPLVKA SVIPKQELWG 190 200 RRSIFMLENK PLMVAEVFLP DAFAYQ

References

[1]

"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses." Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 34H / ATCC BAA-681.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000083 Genomic DNA. Translation: AAZ28672.1. Different initiation.
RefSeq	YP_266893.1. NC_003910.7.
3D structure databases
ProteinModelPortal	Q48AM0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q48AM0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3522933.
GenomeReviews	Gene locus CPS_0125 in contig CP000083_GR.
KEGG	cps:CPS_0125.
NMPDR	fig|167879.3.peg.128.
PATRIC	21463665. VBIColPsy94388_0103.
TIGR	CPS_0125.
Phylogenomic databases
eggNOG	COG3161.
HOGENOM	HBG644467.
ProtClustDB	CLSK742489.
Enzyme and pathway databases
BioCyc	CPSY167879:CPS_0125-MONOMER.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
KO	K03181.
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_COLP3

Accession

Primary (citable) accession number: Q48AM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 26, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program