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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:CPS_0133
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
Proteomesi
  • UP000000547 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000494291 – 811Glycerol-3-phosphate acyltransferaseAdd BLAST811

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_0133.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi309 – 314HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48AL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALRSFFYL LLKFPLKLLV RCKIITDSQN ITDQPNQPIF YIVRHQSASD
60 70 80 90 100
LLALQSACKK QNLPDPLGKV TINGESFNRT LCLAKSTPLC SWRKSSKTTA
110 120 130 140 150
TAQGLALLNQ HVIDENIDAK LIPANLIWGR TPTKERKNLN IGTLLADQES
160 170 180 190 200
PNWLRKFFIV LFLGRDTLVR FSEAFSLRNI SDNHGSDEAA AHKFLRVARF
210 220 230 240 250
HFHRQTIAAK GPRLMHRKQM FTALFANPSV KRIISDEAKN KKVSEAEIKK
260 270 280 290 300
KALVMMNEIA GDYSVSWLRF GEIILHWLWK RLYSAIKVSN AKVLRKLAQD
310 320 330 340 350
GHEIIYVPCH RSHMDYLLLS YVILQEGLVM PRIAAGINLN FWPAGTIFRK
360 370 380 390 400
GGAFFIRRSF GGNRLYSTIF REYLGLLFER GYGVKYYTEG GRSRTGRVLA
410 420 430 440 450
PKTGMLAMTI QSLLRGIDRP LTLVPVYLGY EHVMEVGTYH KELSGSEKKG
460 470 480 490 500
ESMFGVLKAI KSLRNYGNGY VNFGEPMNIN EFLNKQVPDW KDSIDPIDPQ
510 520 530 540 550
KPSWLTPTVN VLADQVMENI NKSAALNGVA LIALILHASK NKALSKLELE
560 570 580 590 600
TQLDFFLNIQ RQAPFSEQLT IPEETGAELL THVISLNKVT ITEDSFGSLV
610 620 630 640 650
SLSETANTEM RYYRNNILHT YVVPALVCRL LDKHSKINQD ELVIKVQNVT
660 670 680 690 700
ALLKEDLYLY QDSTHVEQQT LRVLTVLKEM EIAKQTKAGF WSLSDDVGLL
710 720 730 740 750
SQVHAMAECI DESLQRLAII TSLTSRLAPL SKRDLETKVV AIAKRLSVLN
760 770 780 790 800
NINAPEFIDK RAQSTLIATI REQGYIDLDD DGLLIASSTM AEIKATVINL
810
VDIEVLQSIA R
Length:811
Mass (Da):91,530
Last modified:September 13, 2005 - v1
Checksum:i8D4D8AA84F1B673B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA. Translation: AAZ27641.1.
RefSeqiWP_011041008.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ27641; AAZ27641; CPS_0133.
KEGGicps:CPS_0133.
PATRICi21463681. VBIColPsy94388_0111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA. Translation: AAZ27641.1.
RefSeqiWP_011041008.1. NC_003910.7.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi167879.CPS_0133.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ27641; AAZ27641; CPS_0133.
KEGGicps:CPS_0133.
PATRICi21463681. VBIColPsy94388_0111.

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_COLP3
AccessioniPrimary (citable) accession number: Q48AL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.