Q48A85 (GPH_COLP3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycolate phosphatase
Short name=PGP
Short name=PGPase
EC=3.1.3.18

Gene names

Ordered Locus Names:

CPS_0261

Organism

Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]

Taxonomic identifier

167879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress By similarity. HAMAP MF_00495
Catalytic activity	2-phosphoglycolate + H2O = glycolate + phosphate. HAMAP MF_00495
Pathway	Organic acid metabolism; glycolate biosynthesis; glycolate from 2-phosphoglycolate: step 1/1. HAMAP MF_00495
Sequence similarities	Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphoglycolate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	Phosphoglycolate phosphatase HAMAP MF_00495		PRO_0000238156
Sites
	Active site	12	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q48A85 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: FA9A818C14D90DD2	FASTA	226	24,921
	10 20 30 40 50 60 MKLQEKEVLL FDLDGTLVDS APDLALAVNR TLKDLNKATF DQDTIHHWVG NGAKVLIERA 70 80 90 100 110 120 LSGSAIIDKE LDETLTKDAL TIFLAHYQQC LCIESVLYDD VQEGLLSLKA AGFRLAIITN 130 140 150 160 170 180 KPAIFIQPIL TGLGIDNLFE LLIGGDTLAD KKPHPAPLHY AMKQLNVVAE QCVMIGDSKN 190 200 210 220 DILAAKAANI DSVGLTYGYN YGEDINQYGP QWCFDTFNEL LISLKR

References

[1]

"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses." Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 34H / ATCC BAA-681.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000083 Genomic DNA. Translation: AAZ25705.1.
RefSeq	YP_267028.1. NC_003910.7.
3D structure databases
ProteinModelPortal	Q48A85.
ModBase	Search...
Protein-protein interaction databases
STRING	Q48A85.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3519951.
GenomeReviews	Gene locus CPS_0261 in contig CP000083_GR.
KEGG	cps:CPS_0261.
NMPDR	fig|167879.3.peg.320.
PATRIC	21463917. VBIColPsy94388_0229.
TIGR	CPS_0261.
Phylogenomic databases
eggNOG	COG0546.
HOGENOM	HBG742904.
OMA	CEESELY.
ProtClustDB	PRK13222.
Enzyme and pathway databases
BioCyc	CPSY167879:CPS_0261-MONOMER.
Family and domain databases
HAMAP	MF_00495. GPH_hydrolase_bact. [Tree]
InterPro	IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. IPR006439. HAD-SF_hydro_IA_v1. IPR006402. HAD-SF_hydro_IA_v3. IPR006346. PGP_bact. IPR023198. PGP_dom2. [Graphical view]
Gene3D	G3DSA:3.40.50.1000. HAD-like_dom. 2 hits. G3DSA:1.10.150.240. PGP_dom2. 1 hit.
KO	K01091.
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01549. HAD-SF-IA-v1. 1 hit. TIGR01509. HAD-SF-IA-v3. 1 hit. TIGR01449. PGP_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GPH_COLP3

Accession

Primary (citable) accession number: Q48A85

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program