Reviewed, UniProtKB/Swiss-Prot Q489Q8 (DCUP_COLP3)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	CPS_0448

Organism

Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]

Taxonomic identifier

167879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_1000023899
Regions
	Region	27 – 31	5	Substrate binding By similarity
Sites
	Binding site	77	1	Substrate By similarity
	Binding site	154	1	Substrate By similarity
	Binding site	209	1	Substrate By similarity
	Binding site	328	1	Substrate By similarity
	Site	77	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q489Q8-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 39A164DDE1D10587	FASTA	355	39,354
	10 20 30 40 50 60 MTELKNDTYL RALLKQPVDY TPVWMMRQAG RYLPEYREVR KNAGDFMSVC KNAELACEVT 70 80 90 100 110 120 IQPLRRFPLD AAILFSDILT IPDAMGLGLY FETGEGPKFE RPITCKADVD KIAVPDPEDE 130 140 150 160 170 180 LGYVMNAVRT IRKELKGEVP LIGFSGSPWT LATYMIEGGS SKAFTKIKKM MFAEPQTLHL 190 200 210 220 230 240 LLDKLADSVI SYLNAQIAAG AQSVMVFDTW GGVLSPRDYN EFSLQYMAKI VDGLTRHNEG 250 260 270 280 290 300 RQVPVTLFTK NGGMWLESIA ATGCDAVGLD WTIDIENAKA RVGDKVALQG NMDPSMLYAP 310 320 330 340 350 LPRIEQEVSK ILSGFGEGGT GHVFNLGHGI HPDVNPDHAG HFIESVHRLS KPYHK

References

[1]

"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses." Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000083 Genomic DNA. Translation: AAZ27556.1.
RefSeq	YP_267206.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3521815.
GenomeReviews	Gene locus CPS_0448 in contig CP000083_GR.
KEGG	cps:CPS_0448.
NMPDR	fig|167879.3.peg.566.
TIGR	CPS_0448.
Phylogenomic databases
HOGENOM	Q489Q8.
OMA	Q489Q8. VFTKGGG.
Enzyme and pathway databases
BioCyc	CPSY167879:CPS_0448-MON.
Family and domain databases
HAMAP	MF_00218. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
ProDom	PD003225. Uro_decarbxyls. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_COLP3

Accession

Primary (citable) accession number: Q489Q8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)