Q489P5 (ARGB_COLP3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	CPS_0461

Organism

Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]

Taxonomic identifier

167879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length	260 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 260	260	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000264695
Regions
	Region	45 – 46	2	Substrate binding By similarity
Sites
	Binding site	67	1	Substrate By similarity
	Binding site	159	1	Substrate By similarity
	Site	12	1	Transition state stabilizer By similarity
	Site	218	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q489P5 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 076829774464E8AB	FASTA	260	26,982
	10 20 30 40 50 60 MNNPVLKPLV IKIGGAILEK ESALNALLNV ISQLKNKQVV LVHGGGCVVD EMLAQAGFTT 70 80 90 100 110 120 EKKHGLRVTP KEQVGLISGA LAGTVNKAIV GTANSMDLAA VGLSLNDGDM ISCTLSTQDL 130 140 150 160 170 180 GQVGVPQTNN SKLLDCLLKA KFLPVISSIG ALDNGDLVNV NADDAAVAIC QLLNAELLLL 190 200 210 220 230 240 TDVNGVKDAD GEYLSSLNAE QAQKLIEQGV IAGGMTAKVN AALHAAQQLR RSIAVASWQS 250 260 PEQITQLLDG HGVGTQIQPN

References

[1]

"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses." Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 34H / ATCC BAA-681.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000083 Genomic DNA. Translation: AAZ27722.1.
RefSeq	YP_267219.1. NC_003910.7.
3D structure databases
HSSP	HSSP built from PDB template 2BUF based on UniProtKB Q9HTN2.
ProteinModelPortal	Q489P5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q489P5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3521981.
GenomeReviews	Gene locus CPS_0461 in contig CP000083_GR.
KEGG	cps:CPS_0461.
NMPDR	fig|167879.3.peg.597.
PATRIC	21464275. VBIColPsy94388_0402.
TIGR	CPS_0461.
Phylogenomic databases
eggNOG	COG0548.
HOGENOM	HBG497643.
OMA	GGCLVDD.
ProtClustDB	PRK00942.
Enzyme and pathway databases
BioCyc	CPSY167879:CPS_0461-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_COLP3

Accession

Primary (citable) accession number: Q489P5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program