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Q489F4

- PUR9_COLP3

UniProt

Q489F4 - PUR9_COLP3

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCPSY167879:GI48-552-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:CPS_0552
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
ProteomesiUP000000547: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Bifunctional purine biosynthesis protein PurHPRO_1000018883Add
BLAST

Proteomic databases

PRIDEiQ489F4.

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_0552.

Structurei

3D structure databases

ProteinModelPortaliQ489F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q489F4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTPRPIKRA LLSVSDKAGI VEFAQRLSEK GVDLLSTGGT AKLLAENGIK
60 70 80 90 100
VTEVSDYTGH PEIMDGRVKT LHPKVHGGIL ARRGIDEVVM DENGISAIDM
110 120 130 140 150
VVVNLYPFAN AVSDENCSLE NAIENIDIGG PTMVRAAAKN HKDVTIVVNA
160 170 180 190 200
SDYERVLTEL DNNNDSLTYK TRFDLAIAAY EHTASYDGMI ANYFGKMLPA
210 220 230 240 250
YGETESKASL ENKVKFPRTF NSQFIKTQDL RYGENSHQDA AFYKEENPEE
260 270 280 290 300
ASVSTATQLQ GKALSYNNIA DTDAALECVK EFDEPACVIV KHANPCGVAI
310 320 330 340 350
GDDILAAYEG AYKTDPTSAF GGIIAFNREL DADTAEAIVS RQFVEVIIAP
360 370 380 390 400
SVSDAAAQIV AAKPNLRLLE CGQWDNKTTG FDFKRVNGGL LVQDTDQGRV
410 420 430 440 450
TSDDLTVVTK RQPTDEEMRD LQFCWKVAKF VKSNAIVYVK NSSTIGVGAG
460 470 480 490 500
QMSRVYSAKV AGIKAADENL EVKGSVMASD AFFPFRDGLD AAAEAGITAV
510 520 530
IQPGGSMRDD EVIAAADEHN IAMVFTGMRH FRH
Length:533
Mass (Da):57,793
Last modified:September 13, 2005 - v1
Checksum:i9D91E97F3A8FF883
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA. Translation: AAZ28762.1.
RefSeqiYP_267310.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ28762; AAZ28762; CPS_0552.
GeneIDi3523024.
KEGGicps:CPS_0552.
PATRICi21464443. VBIColPsy94388_0486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA. Translation: AAZ28762.1 .
RefSeqi YP_267310.1. NC_003910.7.

3D structure databases

ProteinModelPortali Q489F4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167879.CPS_0552.

Proteomic databases

PRIDEi Q489F4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ28762 ; AAZ28762 ; CPS_0552 .
GeneIDi 3523024.
KEGGi cps:CPS_0552.
PATRICi 21464443. VBIColPsy94388_0486.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CPSY167879:GI48-552-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 34H / ATCC BAA-681.

Entry informationi

Entry nameiPUR9_COLP3
AccessioniPrimary (citable) accession number: Q489F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3