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Q489F4

- PUR9_COLP3

UniProt

Q489F4 - PUR9_COLP3

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, CPS_0552
Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCPSY167879:GI48-552-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:CPS_0552
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
ProteomesiUP000000547: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018883Add
BLAST

Proteomic databases

PRIDEiQ489F4.

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_0552.

Structurei

3D structure databases

ProteinModelPortaliQ489F4.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q489F4-1 [UniParc]FASTAAdd to Basket

« Hide

MDTPRPIKRA LLSVSDKAGI VEFAQRLSEK GVDLLSTGGT AKLLAENGIK    50
VTEVSDYTGH PEIMDGRVKT LHPKVHGGIL ARRGIDEVVM DENGISAIDM 100
VVVNLYPFAN AVSDENCSLE NAIENIDIGG PTMVRAAAKN HKDVTIVVNA 150
SDYERVLTEL DNNNDSLTYK TRFDLAIAAY EHTASYDGMI ANYFGKMLPA 200
YGETESKASL ENKVKFPRTF NSQFIKTQDL RYGENSHQDA AFYKEENPEE 250
ASVSTATQLQ GKALSYNNIA DTDAALECVK EFDEPACVIV KHANPCGVAI 300
GDDILAAYEG AYKTDPTSAF GGIIAFNREL DADTAEAIVS RQFVEVIIAP 350
SVSDAAAQIV AAKPNLRLLE CGQWDNKTTG FDFKRVNGGL LVQDTDQGRV 400
TSDDLTVVTK RQPTDEEMRD LQFCWKVAKF VKSNAIVYVK NSSTIGVGAG 450
QMSRVYSAKV AGIKAADENL EVKGSVMASD AFFPFRDGLD AAAEAGITAV 500
IQPGGSMRDD EVIAAADEHN IAMVFTGMRH FRH 533
Length:533
Mass (Da):57,793
Last modified:September 13, 2005 - v1
Checksum:i9D91E97F3A8FF883
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ28762.1.
RefSeqiWP_011041413.1. NC_003910.7.
YP_267310.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ28762; AAZ28762; CPS_0552.
GeneIDi3523024.
KEGGicps:CPS_0552.
PATRICi21464443. VBIColPsy94388_0486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ28762.1 .
RefSeqi WP_011041413.1. NC_003910.7.
YP_267310.1. NC_003910.7.

3D structure databases

ProteinModelPortali Q489F4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 167879.CPS_0552.

Proteomic databases

PRIDEi Q489F4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ28762 ; AAZ28762 ; CPS_0552 .
GeneIDi 3523024.
KEGGi cps:CPS_0552.
PATRICi 21464443. VBIColPsy94388_0486.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CPSY167879:GI48-552-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 34H / ATCC BAA-681.

Entry informationi

Entry nameiPUR9_COLP3
AccessioniPrimary (citable) accession number: Q489F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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