Reviewed, UniProtKB/Swiss-Prot Q488Y0 (ASTD_COLP3)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	CPS_0634

Organism

Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]

Taxonomic identifier

167879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_0000262398
Regions
	Nucleotide binding	225 – 230	6	NAD By similarity
Sites
	Active site	248	1	By similarity
	Active site	282	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q488Y0-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 7740FDE2F7F1083F	FASTA	492	52,600
	10 20 30 40 50 60 MSHANPVQFI NGQWQAGLGH DVSSSNPARN EVIWQGKTAS KDQVNDAVLS ARQAFESWAN 70 80 90 100 110 120 ISLEARVAVV TKFAELLAEN KDALATTIAL ETGKPKWETT GEAGAMVAKV AISLKAYNER 130 140 150 160 170 180 TGTVENPMPG AKAFIRHKPH GVVAIFGPYN FPGHLPNGHI VPALIAGNTI VFKPSELTPR 190 200 210 220 230 240 VAQEMLKLWE QAGLPNGVIN LVQGEVETGK ALASHKLIDG LFFTGSSNTG HILHEQFAGQ 250 260 270 280 290 300 PGKILALEMG GNNPLVVKDV SDIDAVVHDI VQSAFVTTGQ RCTCARRLFI EANEQGDAIL 310 320 330 340 350 360 ARLIEVTKNL TIGYYDDEAQ PFMGSMISEK AALSLVDAQA KLLALGAKSV LDLKHLEVGT 370 380 390 400 410 420 GFVSPGIIDV SDIIADIPDE EYFGPLVKLY RYNDFDKAID EANNTGFGLS AGLLSDSEAS 430 440 450 460 470 480 YNHFFTRIRA GIVNWNKPIT GASSAAPFGG IGASGNHRAS AFYAADYCAY PIASVEAEKV 490 SLPETLTPGM KF

References

[1]

"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses." Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000083 Genomic DNA. Translation: AAZ28301.1.
RefSeq	YP_267384.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3522560.
GenomeReviews	Gene locus CPS_0634 in contig CP000083_GR.
KEGG	cps:CPS_0634.
NMPDR	fig|167879.3.peg.377.
TIGR	CPS_0634.
Phylogenomic databases
HOGENOM	Q488Y0.
Enzyme and pathway databases
BioCyc	CPSY167879:CPS_0634-MON.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_COLP3

Accession

Primary (citable) accession number: Q488Y0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	September 13, 2005
Last modified:	November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)