ID   Q48898_METAT            Unreviewed;       238 AA.
AC   Q48898;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   28-JUN-2023, entry version 88.
DE   SubName: Full=Superantigen {ECO:0000313|EMBL:AAC43976.1};
OS   Metamycoplasma arthritidis (Mycoplasma arthritidis).
OC   Bacteria; Mycoplasmatota; Mycoplasmoidales; Metamycoplasmataceae;
OC   Metamycoplasma.
OX   NCBI_TaxID=2111 {ECO:0000313|EMBL:AAC43976.1};
RN   [1] {ECO:0000313|EMBL:AAC43976.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PG-6 {ECO:0000313|EMBL:AAC43976.1};
RX   PubMed=8642252; DOI=10.1084/jem.183.3.1105;
RA   Cole B.C., Knudtson K.L., Oliphant A., Sawitzke A.D., Pole A., Manohar M.,
RA   Benson L.S., Ahmed E., Atkin C.L.;
RT   "The sequence of the Mycoplasma arthritidis superantigen, MAM:
RT   identification of functional domains and comparison with microbial
RT   superantigens and plant lectin mitogens.";
RL   J. Exp. Med. 183:1105-1110(1996).
RN   [2] {ECO:0007829|PDB:1R5I}
RP   X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 26-238.
RX   PubMed=14962388; DOI=10.1016/S0969-2126(04)00020-6;
RA   Zhao Y., Li Z., Drozd S.J., Guo Y., Mourad W., Li H.;
RT   "Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1
RT   reveals a novel superantigen fold and a dimerized superantigen-MHC
RT   complex.";
RL   Structure 12:277-288(2004).
RN   [3] {ECO:0007829|PDB:2OJE}
RP   X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 25-238.
RX   PubMed=17166841; DOI=10.1074/jbc.M608482200;
RA   Li H., Zhao Y., Guo Y., Li Z., Eisele L., Mourad W.;
RT   "Zinc induces dimerization of the class II major histocompatibility complex
RT   molecule that leads to cooperative binding to a superantigen.";
RL   J. Biol. Chem. 282:5991-6000(2007).
RN   [4] {ECO:0007829|PDB:2ICW}
RP   X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) OF 26-238.
RX   PubMed=17220897; DOI=10.1038/nsmb1193;
RA   Wang L., Zhao Y., Li Z., Guo Y., Jones L.L., Kranz D.M., Mourad W., Li H.;
RT   "Crystal structure of a complete ternary complex of TCR, superantigen and
RT   peptide-MHC.";
RL   Nat. Struct. Mol. Biol. 14:169-171(2007).
RN   [5] {ECO:0007829|PDB:3KPH}
RP   X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 26-237.
RX   PubMed=20417218; DOI=10.1016/j.jmb.2010.04.030;
RA   Liu L., Li Z., Guo Y., VanVranken S.J., Mourad W., Li H.;
RT   "Crystal structure of the Mycoplasma arthritidis-derived mitogen in apo
RT   form reveals a 3D domain-swapped dimer.";
RL   J. Mol. Biol. 399:367-376(2010).
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DR   EMBL; U33151; AAC43976.1; -; Genomic_DNA.
DR   RefSeq; WP_012497958.1; NZ_LR215047.1.
DR   PDB; 1R5I; X-ray; 2.60 A; D/H=26-238.
DR   PDB; 2ICW; X-ray; 2.41 A; G/H=26-238.
DR   PDB; 2OJE; X-ray; 3.00 A; D/H=25-238.
DR   PDB; 3KPH; X-ray; 2.80 A; A/B=26-237.
DR   PDBsum; 1R5I; -.
DR   PDBsum; 2ICW; -.
DR   PDBsum; 2OJE; -.
DR   PDBsum; 3KPH; -.
DR   AlphaFoldDB; Q48898; -.
DR   SMR; Q48898; -.
DR   EvolutionaryTrace; Q48898; -.
DR   Gene3D; 1.20.120.390; Hla class ii histocompatibility antigen, dr alpha chain. Chain D, domain 1; 1.
DR   Gene3D; 1.10.10.530; mam-mhc complex, Chain D, Domain 2; 1.
DR   InterPro; IPR015326; M_arthritidis-der_mitogen.
DR   InterPro; IPR042074; M_arthritidis-der_mitogen_C.
DR   InterPro; IPR036342; MAM_sf.
DR   Pfam; PF09245; MA-Mit; 1.
DR   SUPFAM; SSF101344; Superantigen MAM; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:1R5I, ECO:0007829|PDB:2ICW}.
SQ   SEQUENCE   238 AA;  27872 MW;  2A005A6263385243 CRC64;
     MKTKKLLIAT VTLATGLLGI LPLTSMKLRV ENPKKAQKHF VQNLNNVVFT NKELEDIYNL
     SNKEETKEVL KLFKLKVNQF YRHAFGIVND YNGLLEYKEI FNMMFLKLSV VFDTQRKEAN
     NVEQIKRNIA ILDEIMAKAD NDLSYFISQN KNFQELWDKA VKLTKEMKIK LKGQKLDLRD
     GEVAINKVRE LFGSDKNVKE LWWFRSLLVK GVYLIKRYYE GDIELKTTSD FAKAVFED
//