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Protein
Submitted name:

Superantigen

Gene
N/A
Organism
Mycoplasma arthritidis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
SuperantigenImported
OrganismiMycoplasma arthritidisImported
Taxonomic identifieri2111 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 PotentialImportedAdd
BLAST
Chaini26 – 238213superantigenImportedPRO_5000144721Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R5IX-ray2.60D/H26-238[»]
2ICWX-ray2.41G/H26-238[»]
2OJEX-ray3.00D/H25-238[»]
3KPHX-ray2.80A/B26-237[»]
SMRiQ48898. Positions 25-238.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ48898.

Family & Domainsi

Keywords - Domaini

SignalImported

Family and domain databases

Gene3Di1.10.10.530. 1 hit.
1.20.120.390. 1 hit.
InterProiIPR015326. M_arthritidis-der_mitogen.
IPR013997. M_arthritidis-der_mitogen_C.
IPR014022. M_arthritidis-der_mitogen_N.
[Graphical view]
PfamiPF09245. MA-Mit. 1 hit.
[Graphical view]
SUPFAMiSSF101344. SSF101344. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q48898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKKLLIAT VTLATGLLGI LPLTSMKLRV ENPKKAQKHF VQNLNNVVFT
60 70 80 90 100
NKELEDIYNL SNKEETKEVL KLFKLKVNQF YRHAFGIVND YNGLLEYKEI
110 120 130 140 150
FNMMFLKLSV VFDTQRKEAN NVEQIKRNIA ILDEIMAKAD NDLSYFISQN
160 170 180 190 200
KNFQELWDKA VKLTKEMKIK LKGQKLDLRD GEVAINKVRE LFGSDKNVKE
210 220 230
LWWFRSLLVK GVYLIKRYYE GDIELKTTSD FAKAVFED
Length:238
Mass (Da):27,872
Last modified:October 31, 1996 - v1
Checksum:i2A005A6263385243
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33151 Genomic DNA. Translation: AAC43976.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33151 Genomic DNA. Translation: AAC43976.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R5IX-ray2.60D/H26-238[»]
2ICWX-ray2.41G/H26-238[»]
2OJEX-ray3.00D/H25-238[»]
3KPHX-ray2.80A/B26-237[»]
SMRiQ48898. Positions 25-238.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ48898.

Family and domain databases

Gene3Di1.10.10.530. 1 hit.
1.20.120.390. 1 hit.
InterProiIPR015326. M_arthritidis-der_mitogen.
IPR013997. M_arthritidis-der_mitogen_C.
IPR014022. M_arthritidis-der_mitogen_N.
[Graphical view]
PfamiPF09245. MA-Mit. 1 hit.
[Graphical view]
SUPFAMiSSF101344. SSF101344. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The sequence of the Mycoplasma arthritidis superantigen, MAM: identification of functional domains and comparison with microbial superantigens and plant lectin mitogens."
    Cole B.C., Knudtson K.L., Oliphant A., Sawitzke A.D., Pole A., Manohar M., Benson L.S., Ahmed E., Atkin C.L.
    J. Exp. Med. 183:1105-1110(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PG-6Imported.
  2. "Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex."
    Zhao Y., Li Z., Drozd S.J., Guo Y., Mourad W., Li H.
    Structure 12:277-288(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 26-238.
  3. "Zinc induces dimerization of the class II major histocompatibility complex molecule that leads to cooperative binding to a superantigen."
    Li H., Zhao Y., Guo Y., Li Z., Eisele L., Mourad W.
    J. Biol. Chem. 282:5991-6000(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 25-238.
  4. "Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC."
    Wang L., Zhao Y., Li Z., Guo Y., Jones L.L., Kranz D.M., Mourad W., Li H.
    Nat. Struct. Mol. Biol. 14:169-171(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) OF 26-238.
  5. "Crystal structure of the Mycoplasma arthritidis-derived mitogen in apo form reveals a 3D domain-swapped dimer."
    Liu L., Li Z., Guo Y., VanVranken S.J., Mourad W., Li H.
    J. Mol. Biol. 399:367-376(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 26-237.

Entry informationi

Entry nameiQ48898_MYCAT
AccessioniPrimary (citable) accession number: Q48898
Entry historyi
Integrated into UniProtKB/TrEMBL: October 31, 1996
Last sequence update: October 31, 1996
Last modified: March 3, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.