Q48898 (Q48898_MYCAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Superantigen EMBL AAC43976.1
Organism	Mycoplasma arthritidis EMBL AAC43976.1
Taxonomic identifier	2111 [NCBI]
Taxonomic lineage	cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Mycoplasma

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

Ontologies

Keywords
Domain	Signal EMBL AAC43976.1
Technical term	3D-structure PDB 2OJE PDB 1R5I PDB 2ICW PDB 3KPH
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential EMBL AAC43976.1
	Chain	26 – 238	213	superantigen EMBL AAC43976.1		PRO_5000144721

Sequences

	Sequence		Length	Mass (Da)
	Q48898 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2A005A6263385243	FASTA	238	27,872
	10 20 30 40 50 60 MKTKKLLIAT VTLATGLLGI LPLTSMKLRV ENPKKAQKHF VQNLNNVVFT NKELEDIYNL 70 80 90 100 110 120 SNKEETKEVL KLFKLKVNQF YRHAFGIVND YNGLLEYKEI FNMMFLKLSV VFDTQRKEAN 130 140 150 160 170 180 NVEQIKRNIA ILDEIMAKAD NDLSYFISQN KNFQELWDKA VKLTKEMKIK LKGQKLDLRD 190 200 210 220 230 GEVAINKVRE LFGSDKNVKE LWWFRSLLVK GVYLIKRYYE GDIELKTTSD FAKAVFED

References

[1]	"The sequence of the Mycoplasma arthritidis superantigen, MAM: identification of functional domains and comparison with microbial superantigens and plant lectin mitogens." Cole B.C., Knudtson K.L., Oliphant A., Sawitzke A.D., Pole A., Manohar M., Benson L.S., Ahmed E., Atkin C.L. J. Exp. Med. 183:1105-1110(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: PG-6 EMBL AAC43976.1.
[2]	"Crystal structure of Mycoplasma arthritidis mitogen complexed with HLA-DR1 reveals a novel superantigen fold and a dimerized superantigen-MHC complex." Zhao Y., Li Z., Drozd S.J., Guo Y., Mourad W., Li H. Structure 12:277-288(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 25-238.
[3]	"Zinc induces dimerization of the class II major histocompatibility complex molecule that leads to cooperative binding to a superantigen." Li H., Zhao Y., Guo Y., Li Z., Eisele L., Mourad W. J. Biol. Chem. 282:5991-6000(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 25-238.
[4]	"Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC." Wang L., Zhao Y., Li Z., Guo Y., Jones L.L., Kranz D.M., Mourad W., Li H. Nat. Struct. Mol. Biol. 14:169-171(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) OF 26-238.
[5]	"Crystal structure of the Mycoplasma arthritidis-derived mitogen in apo form reveals a 3D domain-swapped dimer." Liu L., Li Z., Guo Y., VanVranken S.J., Mourad W., Li H. J. Mol. Biol. 399:367-376(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 22-237.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U33151 Genomic DNA. Translation: AAC43976.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1R5I	X-ray	2.60	D/H	25-238	[»]
2ICW	X-ray	2.41	G/H	26-238	[»]
2OJE	X-ray	3.00	D/H	25-238	[»]
3KPH	X-ray	2.80	A/B	22-237	[»]

ProteinModelPortal

Q48898.

SMR

Q48898. Positions 25-238.

ModBase

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Protocols and materials databases

StructuralBiologyKnowledgebase

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Family and domain databases

Gene3D

1.10.10.530. 1 hit.
1.20.120.390. 1 hit.

InterPro

IPR015326. M_arthritidis-der_mitogen.
IPR013997. M_arthritidis-der_mitogen_C.
IPR014022. M_arthritidis-der_mitogen_N.
[Graphical view]

Pfam

PF09245. MA-Mit. 1 hit.
[Graphical view]

SUPFAM

SSF101344. M_arthritidis-der_mitogen. 1 hit.

ProtoNet

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Other

EvolutionaryTrace

Q48898.

Entry information

Entry name

Q48898_MYCAT

Accession

Primary (citable) accession number: Q48898

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)