ID   SDHA_LACSK              Reviewed;         209 AA.
AC   Q48838;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 44.
DE   RecName: Full=Probable L-serine dehydratase, alpha chain;
DE            Short=SDH;
DE            EC=4.3.1.17;
DE   AltName: Full=L-serine deaminase;
DE            Short=L-SD;
DE   Flags: Fragment;
GN   Name=sdhA;
OS   Lactobacillus sakei.
OC   Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1599;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CBS 532.92 / 0-1;
RA   van den Berg D.J.C., Toonen M.Y., Robijn G.W., Kamerling J.P.,
RA   Vliegenthart J.F.G., van der Swaluw C.D.M., Ledoboer A.M.,
RA   Verrips C.T.;
RT   "Isolation, characterization, and disruption of the putative
RT   exopolysaccharide gene cluster from Lactobactillus sake 0-1.";
RL   Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-serine = pyruvate + NH(3).
CC   -!- COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
CC   -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the iron-sulfur dependent L-serine
CC       dehydratase family.
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DR   EMBL; X98238; CAA66890.1; -; Genomic_DNA.
DR   BRENDA; 4.3.1.17; 273663.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003941; F:L-serine ammonia-lyase activity; IEA:EC.
DR   GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR004642; L-Ser_deHydtase_asu.
DR   InterPro; IPR005130; Ser_deHydtase_asu.
DR   Pfam; PF03313; SDH_alpha; 1.
DR   TIGRFAMs; TIGR00718; sda_alpha; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Gluconeogenesis; Iron; Iron-sulfur; Lyase; Metal-binding.
FT   CHAIN        <1    209       Probable L-serine dehydratase, alpha
FT                                chain.
FT                                /FTId=PRO_0000171914.
FT   NON_TER       1      1
SQ   SEQUENCE   209 AA;  20887 MW;  D180E92BD55670BF CRC64;
     DIMLEAVQNA IATNEVNASM GIICATPTAG SAGTLPGILS VITKQLSLDR DAQIRFLFCA
     SAFGMVVAND AMIAGATGGC QAEVGSASAM GAAAAVEAAG GTHQQSSEAF AMAMSNLLGL
     VCDPVAGLVE VPCVKRNVIG SVNALTSADM ALAGLVSKIP ADEVISAMKS IGENLPSTLR
     ETGLGGLAAT PTGIALKMQI FGQDMSIDK
//