Reviewed, UniProtKB/Swiss-Prot Q48838 (SDHA_LACSK)

Names and origin

Protein names

Recommended name:
    Probable L-serine dehydratase, alpha chain
      Short name=SDH
    EC=4.3.1.17
Alternative name(s):
    L-serine deaminase
      Short name=L-SD

Gene names

Name:

sdhA

Organism

Lactobacillus sakei

Taxonomic identifier

1599 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	209 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-serine = pyruvate + NH3.
Cofactor	Binds 1 4Fe-4S cluster By similarity.
Pathway	Carbohydrate biosynthesis; gluconeogenesis.
Subunit structure	Heterodimer of an alpha chain and a beta chain By similarity.
Sequence similarities	Belongs to the iron-sulfur dependent L-serine dehydratase family.

Ontologies

Keywords
Biological process	Gluconeogenesis
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Lyase
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW L-serine ammonia-lyase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 209	›209	Probable L-serine dehydratase, alpha chain		PRO_0000171914
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q48838-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D180E92BD55670BF	FASTA	209	20,887
	10 20 30 40 50 60 DIMLEAVQNA IATNEVNASM GIICATPTAG SAGTLPGILS VITKQLSLDR DAQIRFLFCA 70 80 90 100 110 120 SAFGMVVAND AMIAGATGGC QAEVGSASAM GAAAAVEAAG GTHQQSSEAF AMAMSNLLGL 130 140 150 160 170 180 VCDPVAGLVE VPCVKRNVIG SVNALTSADM ALAGLVSKIP ADEVISAMKS IGENLPSTLR 190 200 ETGLGGLAAT PTGIALKMQI FGQDMSIDK

References

[1]

"Isolation, characterization, and disruption of the putative exopolysaccharide gene cluster from Lactobactillus sake 0-1." van den Berg D.J.C., Toonen M.Y., Robijn G.W., Kamerling J.P., Vliegenthart J.F.G., van der Swaluw C.D.M., Ledoboer A.M., Verrips C.T. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CBS 532.92 / 0-1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X98238 Genomic DNA. Translation: CAA66890.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.3.1.17. 273663.
Family and domain databases
InterPro	IPR004642. L-Ser_deHydtase_asu. IPR005130. Ser_deHydtase_asu. [Graphical view]
Pfam	PF03313. SDH_alpha. 1 hit. [Graphical view]
TIGRFAMs	TIGR00718. sda_alpha. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SDHA_LACSK

Accession

Primary (citable) accession number: Q48838

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)