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Reviewed, UniProtKB/Swiss-Prot Q48838 (SDHA_LACSK)

Last modified June 16, 2009. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Probable L-serine dehydratase, alpha chain
      Short name=SDH
    EC=4.3.1.17
Alternative name(s):
    L-serine deaminase
      Short name=L-SD
Gene names
Name: sdhA
OrganismLactobacillus sakei
Taxonomic identifier1599 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length209 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

L-serine = pyruvate + NH3.

Cofactor

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Subunit structure

Heterodimer of an alpha chain and a beta chain By similarity.

Sequence similarities

Belongs to the iron-sulfur dependent L-serine dehydratase family.

Ontologies

Keywords
   Biological processGluconeogenesis
   Ligand4Fe-4S
Iron
Iron-sulfur
Metal-binding
   Molecular functionLyase
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function4 iron, 4 sulfur cluster binding

Inferred from electronic annotation. Source: UniProtKB-KW

L-serine ammonia-lyase activity

Inferred from electronic annotation. Source: EC

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 209›209Probable L-serine dehydratase, alpha chain
PRO_0000171914

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q48838-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D180E92BD55670BF

FASTA20920,887
        10         20         30         40         50         60 
DIMLEAVQNA IATNEVNASM GIICATPTAG SAGTLPGILS VITKQLSLDR DAQIRFLFCA 

        70         80         90        100        110        120 
SAFGMVVAND AMIAGATGGC QAEVGSASAM GAAAAVEAAG GTHQQSSEAF AMAMSNLLGL 

       130        140        150        160        170        180 
VCDPVAGLVE VPCVKRNVIG SVNALTSADM ALAGLVSKIP ADEVISAMKS IGENLPSTLR 

       190        200 
ETGLGGLAAT PTGIALKMQI FGQDMSIDK 

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References

[1]"Isolation, characterization, and disruption of the putative exopolysaccharide gene cluster from Lactobactillus sake 0-1."
van den Berg D.J.C., Toonen M.Y., Robijn G.W., Kamerling J.P., Vliegenthart J.F.G., van der Swaluw C.D.M., Ledoboer A.M., Verrips C.T.
Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CBS 532.92 / 0-1.

Cross-references

Sequence databases

X98238 Genomic DNA. Translation: CAA66890.1.

3D structure databases

ModBaseSearch...

Enzyme and pathway databases

BRENDA4.3.1.17. 273663.

Family and domain databases

InterProIPR004642. L-Ser_deHydtase_asu.
IPR005130. Ser_deHydtase_asu.
[Graphical view]
PfamPF03313. SDH_alpha. 1 hit.
[Graphical view]
TIGRFAMsTIGR00718. sda_alpha. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSDHA_LACSK
AccessionPrimary (citable) accession number: Q48838
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents