Reviewed, UniProtKB/Swiss-Prot Q48806 (DLPA_LEGPH)

Names and origin

Protein names

Recommended name:
    Protein dlpA

Gene names

Name:	dlpA
Ordered Locus Names:	lpg2683

Organism

Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) [Complete proteome] [HAMAP]

Taxonomic identifier

272624 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	615 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. To M.jannaschii MJ0644 in the C-terminal section.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 615	615	Protein dlpA		PRO_0000083821

Sequences

	Sequence		Length	Mass (Da)
	Q48806-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 78387A390E7695E4	FASTA	615	67,705
	10 20 30 40 50 60 MKSTDPIKIA VLPGDGIGIE VTEATLPVFE VLDVPVILNY GDIGWEFWKK EGAAIPSRTW 70 80 90 100 110 120 QLIASSDTVL LGAITSKPQR EAKQELSNAL KKSNPYYVSP VIQLRQGLDL FANVRPCFSI 130 140 150 160 170 180 DDQSKPFNFC IIRENSEGLY CGFDYFPLPK AIHSLLAESQ HWQTIPADEA SCALRLQSKS 190 200 210 220 230 240 GLTRLFDFAF KHAMQTGMPR VTLADKPNVL RESGEFTRKI FESTAQRYPK IQADILNVDA 250 260 270 280 290 300 VALWLIKSPE KFGVIVAENM FGDILSDVGA GVMGGLGLAP SANIGDKGSY FEPVHGSGPR 310 320 330 340 350 360 IRKNCANPSA MFLTISMLLN HFGYPDRAKK IVNAVMQVIK EKRFITYDLG GHATTTDMAN 370 380 390 400 410 420 AVIEHCARLN ASCLSKDFNP TPKENLIESD TMPNLLQQLI NCNSAEISDA LDACGIEGGL 430 440 450 460 470 480 LSIKPLSQGM KIIGPAYTIQ YLPREKKGTA FHNAANYIDK VPKHSVIVID NNGQIDCTVW 490 500 510 520 530 540 GDLLTHTALR NNIMGTVVHG AVRDVESIRS TNYPVFCTGI YMCSGKNRVY KANEQCPLSI 550 560 570 580 590 600 NGVTINPGDI IFADDNGVLV IPNDRLQEVV NKTIAIRLTE ERIKTAIASG STLEQAREDY 610 CYEQPWLGIN KKRES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene." Berger K.H., Merriam J.J., Isberg R.R. Mol. Microbiol. 14:809-822(1994) [PubMed: 7891566] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genomic sequence of the accidental pathogen Legionella pneumophila." Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G., Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V., Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S. , Georghiou A., Chou I.-C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A., Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A., Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A., Russo J.J. Science 305:1966-1968(2004) [PubMed: 15448271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U07940 Genomic DNA. Translation: AAA79904.1. AE017354 Genomic DNA. Translation: AAU28741.1.
PIR	S61390.
RefSeq	YP_096688.1.
3D structure databases
HSSP	HSSP built from PDB template 1XAA based on UniProtKB P00351.
ModBase	Search...
Genome annotation databases
GeneID	3079431.
GenomeReviews	Gene locus lpg2683 in contig AE017354_GR.
KEGG	lpn:lpg2683.
NMPDR	fig|272624.3.peg.2633.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q48806.
OMA	Q48806. MANAVIE.
Enzyme and pathway databases
BioCyc	LPNE272624:LPG2683-MON.
Family and domain databases
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR005493. RNaseE_inh/diMeMenaQ_MeTrfase. [Graphical view]
Gene3D	G3DSA:3.40.718.10. IDH_IMDH. 1 hit. G3DSA:3.50.30.40. RNaseE_inh/diMeMenaQ_MeTrfase. 1 hit.
PANTHER	PTHR11835. IDH_IMDH_dimeric. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. PF03737. Methyltransf_6. 1 hit. [Graphical view]
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLPA_LEGPH

Accession

Primary (citable) accession number: Q48806
Secondary accession number(s): Q5ZS36

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)