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Protein

Protein DlpA

Gene

dlpA

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. NAD binding Source: InterPro
  3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-2682-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DlpA
Gene namesi
Name:dlpA
Ordered Locus Names:lpg2683
OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Taxonomic identifieri272624 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000000609: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 615615Protein DlpAPRO_0000083821Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272624.lpg2683.

Structurei

3D structure databases

ProteinModelPortaliQ48806.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

To M.jannaschii MJ0644 in the C-terminal section.Curated

Phylogenomic databases

eggNOGiCOG0684.
HOGENOMiHOG000278037.
OMAiCIIRENS.
OrthoDBiEOG64BQ2K.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
3.50.30.40. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
IPR005493. RNase_E_inh/diMeMenaQ_MeTrfase.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
PF03737. Methyltransf_6. 1 hit.
[Graphical view]
SUPFAMiSSF89562. SSF89562. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSTDPIKIA VLPGDGIGIE VTEATLPVFE VLDVPVILNY GDIGWEFWKK
60 70 80 90 100
EGAAIPSRTW QLIASSDTVL LGAITSKPQR EAKQELSNAL KKSNPYYVSP
110 120 130 140 150
VIQLRQGLDL FANVRPCFSI DDQSKPFNFC IIRENSEGLY CGFDYFPLPK
160 170 180 190 200
AIHSLLAESQ HWQTIPADEA SCALRLQSKS GLTRLFDFAF KHAMQTGMPR
210 220 230 240 250
VTLADKPNVL RESGEFTRKI FESTAQRYPK IQADILNVDA VALWLIKSPE
260 270 280 290 300
KFGVIVAENM FGDILSDVGA GVMGGLGLAP SANIGDKGSY FEPVHGSGPR
310 320 330 340 350
IRKNCANPSA MFLTISMLLN HFGYPDRAKK IVNAVMQVIK EKRFITYDLG
360 370 380 390 400
GHATTTDMAN AVIEHCARLN ASCLSKDFNP TPKENLIESD TMPNLLQQLI
410 420 430 440 450
NCNSAEISDA LDACGIEGGL LSIKPLSQGM KIIGPAYTIQ YLPREKKGTA
460 470 480 490 500
FHNAANYIDK VPKHSVIVID NNGQIDCTVW GDLLTHTALR NNIMGTVVHG
510 520 530 540 550
AVRDVESIRS TNYPVFCTGI YMCSGKNRVY KANEQCPLSI NGVTINPGDI
560 570 580 590 600
IFADDNGVLV IPNDRLQEVV NKTIAIRLTE ERIKTAIASG STLEQAREDY
610
CYEQPWLGIN KKRES
Length:615
Mass (Da):67,705
Last modified:November 1, 1996 - v1
Checksum:i78387A390E7695E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07940 Genomic DNA. Translation: AAA79904.1.
AE017354 Genomic DNA. Translation: AAU28741.1.
PIRiS61390.
RefSeqiWP_010948383.1. NC_002942.5.
YP_096688.1. NC_002942.5.

Genome annotation databases

EnsemblBacteriaiAAU28741; AAU28741; lpg2683.
GeneIDi19834248.
KEGGilpn:lpg2683.
PATRICi22332725. VBILegPne29832_2864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07940 Genomic DNA. Translation: AAA79904.1.
AE017354 Genomic DNA. Translation: AAU28741.1.
PIRiS61390.
RefSeqiWP_010948383.1. NC_002942.5.
YP_096688.1. NC_002942.5.

3D structure databases

ProteinModelPortaliQ48806.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272624.lpg2683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU28741; AAU28741; lpg2683.
GeneIDi19834248.
KEGGilpn:lpg2683.
PATRICi22332725. VBILegPne29832_2864.

Phylogenomic databases

eggNOGiCOG0684.
HOGENOMiHOG000278037.
OMAiCIIRENS.
OrthoDBiEOG64BQ2K.

Enzyme and pathway databases

BioCyciLPNE272624:GHDI-2682-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
3.50.30.40. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
IPR005493. RNase_E_inh/diMeMenaQ_MeTrfase.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
PF03737. Methyltransf_6. 1 hit.
[Graphical view]
SUPFAMiSSF89562. SSF89562. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene."
    Berger K.H., Merriam J.J., Isberg R.R.
    Mol. Microbiol. 14:809-822(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Philadelphia 1 / ATCC 33152 / DSM 7513.

Entry informationi

Entry nameiDLPA_LEGPH
AccessioniPrimary (citable) accession number: Q48806
Secondary accession number(s): Q5ZS36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.