Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q48743

- AMPC_LYSLA

UniProt

Q48743 - AMPC_LYSLA

Protein

Beta-lactamase

Gene
N/A
Organism
Lysobacter lactamgenus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei84 – 841Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei170 – 1701Proton acceptorBy similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Protein family/group databases

    MEROPSiS12.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase (EC:3.5.2.6)
    Alternative name(s):
    Cephalosporinase
    OrganismiLysobacter lactamgenus
    Taxonomic identifieri39596 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeLysobacter

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 385365Beta-lactamasePRO_0000016960Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ48743.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni335 – 3373Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-C beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q48743-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRLLAFCLL FFAALGQAKV PPPARSAADA EIQRAVAAFM QQYQVPGVAV    50
    GITVDGAERY YNYGVSSRKT QAKVGANTLF EVGSVSKTFT ATLASYAQVN 100
    QQLSLADHPG KYLPEMKGHD FDKVTLLNLG THTAGGFPMQ VPTQVKTDQQ 150
    LTAYFQSWHP QYPAGTKRTY ANPGIGMLGV IAAKSMRMPF QKAMTGVLLP 200
    KLGLTNTYLT VPPAKMAFYA QGYDDKGQPV RMSPGALWEP TYGIKTTARD 250
    LLRFVEINLD QVKVEPKLKR AIDGTHVGYY RLGEMTQGLV WEQLPYPASE 300
    TSLQANSSQK VIFESNAVAA LTPPRPPQAN VLINKTGSTR GFGAYVAFNP 350
    ARKIGIVLLM NRSVPMDGRI KLAHTILDTA GGMAK 385
    Length:385
    Mass (Da):41,878
    Last modified:November 1, 1996 - v1
    Checksum:i33DA95118FC2B207
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56660 Genomic DNA. Translation: CAA39987.1.
    PIRiS54103.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56660 Genomic DNA. Translation: CAA39987.1 .
    PIRi S54103.

    3D structure databases

    ProteinModelPortali Q48743.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S12.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of the gene cluster involved in cephalosporin biosynthesis from Lysobacter lactamgenus YK90."
      Kimura H., Izawa M., Sumino Y.
      Appl. Microbiol. Biotechnol. 44:589-596(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: YK90.

    Entry informationi

    Entry nameiAMPC_LYSLA
    AccessioniPrimary (citable) accession number: Q48743
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3