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Protein

Beta-galactosidase

Gene

lacZ

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei431Proton donorBy similarity1
Active sitei508NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyciLLAC272623:G1FZA-2092-MONOMER
SABIO-RKiQ48727

Protein family/group databases

CAZyiGH2 Glycoside Hydrolase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
Ordered Locus Names:LL1980
ORF Names:L0025
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000576691 – 998Beta-galactosidaseAdd BLAST998

Proteomic databases

PaxDbiQ48727
PRIDEiQ48727

Interactioni

Protein-protein interaction databases

STRINGi272623.L0025

Structurei

3D structure databases

ProteinModelPortaliQ48727
SMRiQ48727
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Phylogenomic databases

eggNOGiENOG4105CNT Bacteria
COG3250 LUCA
HOGENOMiHOG000252443
KOiK01190
OMAiPSNWQLQ

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR004199 B-gal_small/dom_5
IPR036156 Beta-gal/glucu_dom_sf
IPR011013 Gal_mutarotase_sf_dom
IPR008979 Galactose-bd-like_sf
IPR014718 GH-type_carb-bd
IPR006101 Glyco_hydro_2
IPR023232 Glyco_hydro_2_AS
IPR023933 Glyco_hydro_2_beta_Galsidase
IPR006103 Glyco_hydro_2_cat
IPR023230 Glyco_hydro_2_CS
IPR006102 Glyco_hydro_2_Ig-like
IPR006104 Glyco_hydro_2_N
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
IPR032312 LacZ_4
PANTHERiPTHR10066:SF76 PTHR10066:SF76, 2 hits
PfamiView protein in Pfam
PF02929 Bgal_small_N, 1 hit
PF16353 DUF4981, 1 hit
PF00703 Glyco_hydro_2, 1 hit
PF02836 Glyco_hydro_2_C, 1 hit
PF02837 Glyco_hydro_2_N, 1 hit
PRINTSiPR00132 GLHYDRLASE2
SMARTiView protein in SMART
SM01038 Bgal_small_N, 1 hit
SUPFAMiSSF49303 SSF49303, 2 hits
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
SSF74650 SSF74650, 1 hit
PROSITEiView protein in PROSITE
PS00719 GLYCOSYL_HYDROL_F2_1, 1 hit
PS00608 GLYCOSYL_HYDROL_F2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q48727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMMTMIDVL ERKDWENPVV SNWNRLPMHT PMDLLEKQSL NGLWNFDHFS
60 70 80 90 100
RISDVPKNWL ELTESKTEII VPSNWQIEFK DKSDVPIYTN VTYPIPIQPP
110 120 130 140 150
YVPEANPVGA YSRYFDITKE WLESGHVHLT FEGVGSAFHF WLNGEYGGYS
160 170 180 190 200
EDSRLPAEFD ISNLAKEGQN CLKVLVFRWS KVTYFEDQDM WRMSGIFRSV
210 220 230 240 250
NLQWLPDNYL LDFSIKTDLD EDLDFANVKL QAYAKNIDDA CLEFKLYDDE
260 270 280 290 300
QLIGECHGFD AEIGVVNPKL WSDEIPYLYR LELTLMDRSG AVFHKETKKI
310 320 330 340 350
GIRKIAIEKG QLKINGKALL VRGVNKHEFT PEHGYVVSEE VMIKDIKLMK
360 370 380 390 400
EHNFNAVRCS HYPNDSRWYE LCDEYGLYVM DEANIETHGM TPMNRLTNDP
410 420 430 440 450
TYLPLMSERV TRMVMRDRNH PSIIIWSLGN ESGYGSNHQA LYDWCKSFDS
460 470 480 490 500
SRPVHYEGGD DASRGATDAT DIICPMYARV DSPSINAPYS LKTWMGVAGE
510 520 530 540 550
NRPLILCEYA HDMGNSLGGF GKYWQAFREI DRLQGGFIWD WVDQGLLKDG
560 570 580 590 600
NYAYGGDFGD KPNDRQFSLN GLVFPNRQAK PALREAKYWQ QYYQFELEKT
610 620 630 640 650
PLGQVFAFTV TNEYLFRSTD NEKLCYQLIN GLEVLWENEL ILNMPAGGSM
660 670 680 690 700
RIDLSELPID GTDNLFLNIQ VKTIEKCNLL ESDFEVAHQQ FVLQEKINFT
710 720 730 740 750
DRIDSNEEIT LFEDEELLTV RSAKQKFIFN KSNGNLSRWL DEKGNEKLLH
760 770 780 790 800
ELSEQFTRAP LDNDIGVSEV EHIDPNAWLE RWKGIGFYEL KTLLKTMIIQ
810 820 830 840 850
ATENEVIISV QTDYEAKGKI AFSTIREYHI FRNGELLLKV DFKRNIEFPE
860 870 880 890 900
PARIGLSLQL AEKAENVTYF GLGPDENYPD RRGASLFGQW NLRITDMTTP
910 920 930 940 950
YIFPSENGLR METRELNYDR LKVRAMGQSF AFNLSPYSQN QLAKKGHWHL
960 970 980 990
LEEEAGTWLN IDGFHMGVGG DDSWSPSVAQ EYLLTKGNYH YEVSFKLT
Length:998
Mass (Da):115,440
Last modified:September 26, 2001 - v3
Checksum:i8989FD4287ADDA89
GO

Sequence cautioni

The sequence AAK06078 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA56341 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti34L → F in strain: ATCC 7962. 1
Natural varianti182V → G in strain: ATCC 7962. 1
Natural varianti237I → M in strain: ATCC 7962. 1
Natural varianti629I → T in strain: ATCC 7962. 1
Natural varianti677C → Y in strain: ATCC 7962. 1
Natural varianti702R → K in strain: ATCC 7962. 1
Natural varianti712F → L in strain: ATCC 7962. 1
Natural varianti784 – 785GI → AV in strain: ATCC 7962. 2
Natural varianti796T → N in strain: ATCC 7962. 1
Natural varianti919D → G in strain: ATCC 7962. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60828 Genomic DNA Translation: AAD11504.1
X80037 Genomic DNA Translation: CAA56341.1 Different initiation.
AE005176 Genomic DNA Translation: AAK06078.1 Different initiation.
PIRiD86872
RefSeqiNP_268137.2, NC_002662.1
WP_010906246.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK06078; AAK06078; L0025
GeneIDi1115654
KEGGilla:L0025
PATRICifig|272623.7.peg.2132

Similar proteinsi

Entry informationi

Entry nameiBGAL_LACLA
AccessioniPrimary (citable) accession number: Q48727
Secondary accession number(s): P71448, Q9CE65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: September 26, 2001
Last modified: May 23, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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