Reviewed, UniProtKB/Swiss-Prot Q486J6 (GCSP1_COLP3)

Names and origin

Protein names

Recommended name:
    Glycine dehydrogenase [decarboxylating] 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase 1
    Glycine cleavage system P-protein 1

Gene names

Name:	gcvP1
Ordered Locus Names:	CPS_1276

Organism

Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]

Taxonomic identifier

167879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length	965 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00711
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the gcvP family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 965	965	Glycine dehydrogenase [decarboxylating] 1 HAMAP MF_00711		PRO_0000227102
Amino acid modifications
	Modified residue	713	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q486J6-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 2D76B8A433A614DB	FASTA	965	104,676
	10 20 30 40 50 60 MTSKTIVNSL AELEQTQDFI RRHIGPSESE TQAMLNDLGV ESVDALIDEI VPSDIRLADL 70 80 90 100 110 120 PNVEESKTEV QALADLKAVA SLNKVNDTYI GLGYFGTLTP NVILRNVLEN PGWYTAYTPY 130 140 150 160 170 180 QPEIAQGRLE SLLNYQQMCI DLTGLELASA SLLDEGTAAA EAMALAKRVS KNKKSNLFFI 190 200 210 220 230 240 SDDVYPQTID VVKQRAEMFG FDIVVAPAAD AAEHDIFGAL IQYPGASGQV TDVSELIAKI 250 260 270 280 290 300 HDNKGIVAVA ADIMSLVLLK SPGELGADAV IGSSQRFGVP MGYGGPHAAF FTTLDKYKRS 310 320 330 340 350 360 LPGRIIGVSK DTRGKNALRM AMQTREQHIR REKANSNVCT AQVLLANMAA FYAVYHGPQG 370 380 390 400 410 420 LKTIANRIHR LADILCLGTA TKGLTAVHAN YFDTLTFNVD NKDEIVARAL AANANFRTDV 430 440 450 460 470 480 DGQISIALDE TTTRENVAQL FDILLGEGHG LNVSDLDDQI VASGHSSIPA SLVRESAILT 490 500 510 520 530 540 HPVFNSYHSE TEMLRYIKRL ENKDLALNHS MISLGSCTMK LNATAQMIPV SWPEFANMHP 550 560 570 580 590 600 FAPVNQAQGY KAMIDELAKW LVELTGYDKM SMQPNSGAQG EYAGLIAISK YHESRGDSHR 610 620 630 640 650 660 NICLIPASAH GTNPASAMMV DMKIVIVACD KEGNVDMADL KAKAEELADN LACIMITYPS 670 680 690 700 710 720 THGVYETTIA EICNIIHDNG GQVYLDGANM NAQVGLTSPG FIGADVSHLN LHKTFAIPHG 730 740 750 760 770 780 GGGPGMGPIG VKSHLAPFLP DHALINVDEA TKGNGAVSSA PFGSASILPI TYLYIALLGK 790 800 810 820 830 840 KGVTDATKYA ITNANYVSKK LSEHYPILYS GKNGRVAHEC IVDLRPLKAS SGVTEVDMAK 850 860 870 880 890 900 RLMDYGFHSP TMSFPVAGTF MIEPTESESK VELDRFIEAM VCIRDEVRKV ESGEWASDNN 910 920 930 940 950 960 PLHNAPHTLA DITEPWDRPY SIQEAVFPVV AVTANKFWPT VNRIDDVFGD RNLICSCPPI ESYID

References

[1]

"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses." Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000083 Genomic DNA. Translation: AAZ27305.1.
RefSeq	YP_268019.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3521561.
GenomeReviews	Gene locus CPS_1276 in contig CP000083_GR.
KEGG	cps:CPS_1276.
NMPDR	fig|167879.3.peg.1237.
TIGR	CPS_1276.
Phylogenomic databases
HOGENOM	Q486J6.
OMA	Q486J6. PAVNRVD.
Enzyme and pathway databases
BioCyc	CPSY167879:CPS_1276-MON.
Family and domain databases
HAMAP	MF_00711. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
TIGRFAMs	TIGR00461. gcvP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCSP1_COLP3

Accession

Primary (citable) accession number: Q486J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	September 13, 2005
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)