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Q486J6 (GCSP1_COLP3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating) 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein 1
Glycine decarboxylase 1
Glycine dehydrogenase (aminomethyl-transferring) 1
Gene names
Name:gcvP1
Ordered Locus Names:CPS_1276
OrganismColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]
Taxonomic identifier167879 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia

Protein attributes

Sequence length965 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 965965Glycine dehydrogenase (decarboxylating) 1 HAMAP-Rule MF_00711
PRO_0000227102

Amino acid modifications

Modified residue7131N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q486J6 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: 2D76B8A433A614DB

FASTA965104,676
        10         20         30         40         50         60 
MTSKTIVNSL AELEQTQDFI RRHIGPSESE TQAMLNDLGV ESVDALIDEI VPSDIRLADL 

        70         80         90        100        110        120 
PNVEESKTEV QALADLKAVA SLNKVNDTYI GLGYFGTLTP NVILRNVLEN PGWYTAYTPY 

       130        140        150        160        170        180 
QPEIAQGRLE SLLNYQQMCI DLTGLELASA SLLDEGTAAA EAMALAKRVS KNKKSNLFFI 

       190        200        210        220        230        240 
SDDVYPQTID VVKQRAEMFG FDIVVAPAAD AAEHDIFGAL IQYPGASGQV TDVSELIAKI 

       250        260        270        280        290        300 
HDNKGIVAVA ADIMSLVLLK SPGELGADAV IGSSQRFGVP MGYGGPHAAF FTTLDKYKRS 

       310        320        330        340        350        360 
LPGRIIGVSK DTRGKNALRM AMQTREQHIR REKANSNVCT AQVLLANMAA FYAVYHGPQG 

       370        380        390        400        410        420 
LKTIANRIHR LADILCLGTA TKGLTAVHAN YFDTLTFNVD NKDEIVARAL AANANFRTDV 

       430        440        450        460        470        480 
DGQISIALDE TTTRENVAQL FDILLGEGHG LNVSDLDDQI VASGHSSIPA SLVRESAILT 

       490        500        510        520        530        540 
HPVFNSYHSE TEMLRYIKRL ENKDLALNHS MISLGSCTMK LNATAQMIPV SWPEFANMHP 

       550        560        570        580        590        600 
FAPVNQAQGY KAMIDELAKW LVELTGYDKM SMQPNSGAQG EYAGLIAISK YHESRGDSHR 

       610        620        630        640        650        660 
NICLIPASAH GTNPASAMMV DMKIVIVACD KEGNVDMADL KAKAEELADN LACIMITYPS 

       670        680        690        700        710        720 
THGVYETTIA EICNIIHDNG GQVYLDGANM NAQVGLTSPG FIGADVSHLN LHKTFAIPHG 

       730        740        750        760        770        780 
GGGPGMGPIG VKSHLAPFLP DHALINVDEA TKGNGAVSSA PFGSASILPI TYLYIALLGK 

       790        800        810        820        830        840 
KGVTDATKYA ITNANYVSKK LSEHYPILYS GKNGRVAHEC IVDLRPLKAS SGVTEVDMAK 

       850        860        870        880        890        900 
RLMDYGFHSP TMSFPVAGTF MIEPTESESK VELDRFIEAM VCIRDEVRKV ESGEWASDNN 

       910        920        930        940        950        960 
PLHNAPHTLA DITEPWDRPY SIQEAVFPVV AVTANKFWPT VNRIDDVFGD RNLICSCPPI 


ESYID 

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References

[1]"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses."
Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. expand/collapse author list , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 34H / ATCC BAA-681.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000083 Genomic DNA. Translation: AAZ27305.1.
RefSeqYP_268019.1. NC_003910.7.

3D structure databases

ProteinModelPortalQ486J6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING167879.CPS_1276.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ27305; AAZ27305; CPS_1276.
GeneID3521561.
KEGGcps:CPS_1276.
PATRIC21465787. VBIColPsy94388_1145.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAASSEMIP.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycCPSY167879:GI48-1276-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP1_COLP3
AccessionPrimary (citable) accession number: Q486J6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families