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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei197UniRule annotation1
Active sitei224UniRule annotation1
Active sitei321UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:CPS_1523
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
Proteomesi
  • UP000000547 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002254541 – 379Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_1523.

Structurei

3D structure databases

ProteinModelPortaliQ485K0.
SMRiQ485K0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini185 – 379CheB-type methylesteraseUniRule annotationAdd BLAST195

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiYGMPMAV.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q485K0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYKVLVVDD SSFFRRRVTD ILNKDPKLNV IDVAVNGQEA VDKALLLKPD
60 70 80 90 100
VITMDIEMPI LNGIEAVRKI MAQSPTSILM FSSLTHQGAK ATLEALDAGA
110 120 130 140 150
LDFLPKKFSE IAKNSDEAGS LLRQRVVEIA RKSEFSKQRT RTRPAAVNIS
160 170 180 190 200
PKSSRLIADQ HRPLASTSSL VTKDKKVMAA ITRSSGKEYK LLAIGTSTGG
210 220 230 240 250
PVALQKILVQ LEENFPLPII IVQHMPAAFT AAFASRLNSL CKISIKEAAD
260 270 280 290 300
GDVLKPGCAY LAPGGRQMLI SGSENSAKIK ILDDDSPKIT FKPSVDISFG
310 320 330 340 350
SAAKTFAGKV LGVILTGMGS DGKEGARMLK AKGATIWSQD EQSCVVYGMP
360 370
QAIDKAGISE LSLSLDSMAA SMVKEISRG
Length:379
Mass (Da):40,593
Last modified:September 13, 2005 - v1
Checksum:i212512B6C14FA440
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA. Translation: AAZ25939.1.
RefSeqiWP_011042359.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ25939; AAZ25939; CPS_1523.
KEGGicps:CPS_1523.

Similar proteinsi

Entry informationi

Entry nameiCHEB_COLP3
AccessioniPrimary (citable) accession number: Q485K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: November 22, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome