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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPSY167879:GI48-1722-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CPS_1722
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
ProteomesiUP000000547: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Leucine--tRNA ligasePRO_1000009332Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_1722.

Structurei

3D structure databases

ProteinModelPortaliQ484Q5.
SMRiQ484Q5. Positions 228-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi618 – 6225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q484Q5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAIYNPQAI EATVQKFWTD NNTFQAIENP DKEKFYCLAM FPYPSGRLHM
60 70 80 90 100
GHVRNYSLGD VISRYQRMQG KNVMQPMGWD AFGLPAENAA IKNKTAPGKW
110 120 130 140 150
TYENIDYMRN QLQSLGFGYD WGRELATCKP DYYRWEQWFF TQLFEKGLVY
160 170 180 190 200
KKNATVNWDP VDQTVLANEQ VIDGRGWRSG ALVERKQIPQ WFIKITDYAE
210 220 230 240 250
ELLDDLDQLT EWPEQVKTMQ RNWIGRSQGV EMTFAVADST ESFDIYTTRP
260 270 280 290 300
DTLMGVTYVA LAAQHPLAVA AAVDNADLAA FIDECKNSKT TEADMAAMEK
310 320 330 340 350
KGVDTGLKAI HPLTGKLVPV WAANFVLMDY GSGAVMSVPG HDQRDYEFAL
360 370 380 390 400
KYGLAIEQVI AGQEADDINK AAITEKSTLI NSGEFDGLDF EEAFKAISDK
410 420 430 440 450
LISENKGKTT TNYRLRDWGV SRQRYWGTPI PMINLANGES VPVPTNELPV
460 470 480 490 500
VLPEDVVMNG TTSPIKADPE WAKTLYNGEE ALRETDTFDT FMESSWYYAR
510 520 530 540 550
YCSPNDDTQM IDPAKANYWL PVDQYIGGIE HAILHLLYSR FFHKLLRDVG
560 570 580 590 600
LVKCDEPFKK LLCQGMVLAE TYYREADNGA QEWIAPTDVE VERDEKGQIT
610 620 630 640 650
SSISKIDGQP VLSAGMSKMS KSKNNGIDPQ EVIEKYGADT VRLFIMFTSP
660 670 680 690 700
PEQTLEWSDA GVEGAHRFVK RVYKLAHEFV ESTNNSAVVD IAELTLNADH
710 720 730 740 750
KKLRRELHKT IAKVTDDIGR RNTFNTAIAA IMELMNHLGK AKVNSDEDKA
760 770 780 790 800
VMQEAVRAVV LMLTPITPHL CHHLWQLVGG SDENVEDASW PVVDNSALVE
810 820 830 840 850
DEKLIIVQVN GKVRAKITVA ADASKEDVEA LGLNDESVLK FTDGNTIRKV
860
IYIPGKLLNI VAN
Length:863
Mass (Da):97,091
Last modified:September 13, 2005 - v1
Checksum:i86F7EE2A5585161F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA. Translation: AAZ26868.1.
RefSeqiYP_268460.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ26868; AAZ26868; CPS_1722.
GeneIDi3521123.
KEGGicps:CPS_1722.
PATRICi21466613. VBIColPsy94388_1554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA. Translation: AAZ26868.1.
RefSeqiYP_268460.1. NC_003910.7.

3D structure databases

ProteinModelPortaliQ484Q5.
SMRiQ484Q5. Positions 228-408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi167879.CPS_1722.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ26868; AAZ26868; CPS_1722.
GeneIDi3521123.
KEGGicps:CPS_1722.
PATRICi21466613. VBIColPsy94388_1554.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciCPSY167879:GI48-1722-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 34H / ATCC BAA-681.

Entry informationi

Entry nameiSYL_COLP3
AccessioniPrimary (citable) accession number: Q484Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.