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Q484Q5

- SYL_COLP3

UniProt

Q484Q5 - SYL_COLP3

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Protein
Leucine--tRNA ligase
Gene
leuS, CPS_1722
Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCPSY167879:GI48-1722-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:CPS_1722
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
ProteomesiUP000000547: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 863863Leucine--tRNA ligaseUniRule annotation
PRO_1000009332Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_1722.

Structurei

3D structure databases

ProteinModelPortaliQ484Q5.
SMRiQ484Q5. Positions 228-408.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi618 – 6225"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q484Q5-1 [UniParc]FASTAAdd to Basket

« Hide

MEAIYNPQAI EATVQKFWTD NNTFQAIENP DKEKFYCLAM FPYPSGRLHM    50
GHVRNYSLGD VISRYQRMQG KNVMQPMGWD AFGLPAENAA IKNKTAPGKW 100
TYENIDYMRN QLQSLGFGYD WGRELATCKP DYYRWEQWFF TQLFEKGLVY 150
KKNATVNWDP VDQTVLANEQ VIDGRGWRSG ALVERKQIPQ WFIKITDYAE 200
ELLDDLDQLT EWPEQVKTMQ RNWIGRSQGV EMTFAVADST ESFDIYTTRP 250
DTLMGVTYVA LAAQHPLAVA AAVDNADLAA FIDECKNSKT TEADMAAMEK 300
KGVDTGLKAI HPLTGKLVPV WAANFVLMDY GSGAVMSVPG HDQRDYEFAL 350
KYGLAIEQVI AGQEADDINK AAITEKSTLI NSGEFDGLDF EEAFKAISDK 400
LISENKGKTT TNYRLRDWGV SRQRYWGTPI PMINLANGES VPVPTNELPV 450
VLPEDVVMNG TTSPIKADPE WAKTLYNGEE ALRETDTFDT FMESSWYYAR 500
YCSPNDDTQM IDPAKANYWL PVDQYIGGIE HAILHLLYSR FFHKLLRDVG 550
LVKCDEPFKK LLCQGMVLAE TYYREADNGA QEWIAPTDVE VERDEKGQIT 600
SSISKIDGQP VLSAGMSKMS KSKNNGIDPQ EVIEKYGADT VRLFIMFTSP 650
PEQTLEWSDA GVEGAHRFVK RVYKLAHEFV ESTNNSAVVD IAELTLNADH 700
KKLRRELHKT IAKVTDDIGR RNTFNTAIAA IMELMNHLGK AKVNSDEDKA 750
VMQEAVRAVV LMLTPITPHL CHHLWQLVGG SDENVEDASW PVVDNSALVE 800
DEKLIIVQVN GKVRAKITVA ADASKEDVEA LGLNDESVLK FTDGNTIRKV 850
IYIPGKLLNI VAN 863
Length:863
Mass (Da):97,091
Last modified:September 13, 2005 - v1
Checksum:i86F7EE2A5585161F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ26868.1.
RefSeqiYP_268460.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ26868; AAZ26868; CPS_1722.
GeneIDi3521123.
KEGGicps:CPS_1722.
PATRICi21466613. VBIColPsy94388_1554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ26868.1 .
RefSeqi YP_268460.1. NC_003910.7.

3D structure databases

ProteinModelPortali Q484Q5.
SMRi Q484Q5. Positions 228-408.
ModBasei Search...

Protein-protein interaction databases

STRINGi 167879.CPS_1722.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ26868 ; AAZ26868 ; CPS_1722 .
GeneIDi 3521123.
KEGGi cps:CPS_1722.
PATRICi 21466613. VBIColPsy94388_1554.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CPSY167879:GI48-1722-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 34H / ATCC BAA-681.

Entry informationi

Entry nameiSYL_COLP3
AccessioniPrimary (citable) accession number: Q484Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi