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Q484Q5

- SYL_COLP3

UniProt

Q484Q5 - SYL_COLP3

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei621 – 6211ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCPSY167879:GI48-1722-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:CPS_1722
    OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
    Taxonomic identifieri167879 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
    ProteomesiUP000000547: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 863863Leucine--tRNA ligasePRO_1000009332Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167879.CPS_1722.

    Structurei

    3D structure databases

    ProteinModelPortaliQ484Q5.
    SMRiQ484Q5. Positions 228-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi618 – 6225"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiMAFAGPP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q484Q5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAIYNPQAI EATVQKFWTD NNTFQAIENP DKEKFYCLAM FPYPSGRLHM    50
    GHVRNYSLGD VISRYQRMQG KNVMQPMGWD AFGLPAENAA IKNKTAPGKW 100
    TYENIDYMRN QLQSLGFGYD WGRELATCKP DYYRWEQWFF TQLFEKGLVY 150
    KKNATVNWDP VDQTVLANEQ VIDGRGWRSG ALVERKQIPQ WFIKITDYAE 200
    ELLDDLDQLT EWPEQVKTMQ RNWIGRSQGV EMTFAVADST ESFDIYTTRP 250
    DTLMGVTYVA LAAQHPLAVA AAVDNADLAA FIDECKNSKT TEADMAAMEK 300
    KGVDTGLKAI HPLTGKLVPV WAANFVLMDY GSGAVMSVPG HDQRDYEFAL 350
    KYGLAIEQVI AGQEADDINK AAITEKSTLI NSGEFDGLDF EEAFKAISDK 400
    LISENKGKTT TNYRLRDWGV SRQRYWGTPI PMINLANGES VPVPTNELPV 450
    VLPEDVVMNG TTSPIKADPE WAKTLYNGEE ALRETDTFDT FMESSWYYAR 500
    YCSPNDDTQM IDPAKANYWL PVDQYIGGIE HAILHLLYSR FFHKLLRDVG 550
    LVKCDEPFKK LLCQGMVLAE TYYREADNGA QEWIAPTDVE VERDEKGQIT 600
    SSISKIDGQP VLSAGMSKMS KSKNNGIDPQ EVIEKYGADT VRLFIMFTSP 650
    PEQTLEWSDA GVEGAHRFVK RVYKLAHEFV ESTNNSAVVD IAELTLNADH 700
    KKLRRELHKT IAKVTDDIGR RNTFNTAIAA IMELMNHLGK AKVNSDEDKA 750
    VMQEAVRAVV LMLTPITPHL CHHLWQLVGG SDENVEDASW PVVDNSALVE 800
    DEKLIIVQVN GKVRAKITVA ADASKEDVEA LGLNDESVLK FTDGNTIRKV 850
    IYIPGKLLNI VAN 863
    Length:863
    Mass (Da):97,091
    Last modified:September 13, 2005 - v1
    Checksum:i86F7EE2A5585161F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000083 Genomic DNA. Translation: AAZ26868.1.
    RefSeqiYP_268460.1. NC_003910.7.

    Genome annotation databases

    EnsemblBacteriaiAAZ26868; AAZ26868; CPS_1722.
    GeneIDi3521123.
    KEGGicps:CPS_1722.
    PATRICi21466613. VBIColPsy94388_1554.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000083 Genomic DNA. Translation: AAZ26868.1 .
    RefSeqi YP_268460.1. NC_003910.7.

    3D structure databases

    ProteinModelPortali Q484Q5.
    SMRi Q484Q5. Positions 228-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167879.CPS_1722.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ26868 ; AAZ26868 ; CPS_1722 .
    GeneIDi 3521123.
    KEGGi cps:CPS_1722.
    PATRICi 21466613. VBIColPsy94388_1554.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi MAFAGPP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CPSY167879:GI48-1722-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 34H / ATCC BAA-681.

    Entry informationi

    Entry nameiSYL_COLP3
    AccessioniPrimary (citable) accession number: Q484Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3