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Reviewed, UniProtKB/Swiss-Prot Q48485 (GLF1_KLEPN)

Last modified June 16, 2009. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Probable UDP-galactopyranose mutase
    EC=5.4.99.9
Gene names
Name: rfbD
OrganismKlebsiella pneumoniae
Taxonomic identifier573 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in the conversion of UDP-GalP into UDP-GalF through a 2-keto intermediate.

Catalytic activity

UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose.

Cofactor

FAD By similarity.

Pathway

Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   LigandFAD
Flavoprotein
   Molecular functionIsomerase
   Technical term3D-structure
Gene Ontology (GO)
   Biological processlipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionUDP-galactopyranose mutase activity

Inferred from electronic annotation. Source: EC

binding

Inferred from electronic annotation. Source: InterPro

oxidoreductase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384Probable UDP-galactopyranose mutase
PRO_0000087506

Regions

Nucleotide binding5 – 3329FAD Potential

Secondary structure

................................................................... 384
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q48485-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: B74EC65EA5B751AB

FASTA38444,457
        10         20         30         40         50         60 
MKSKKILIVG AGFSGAVIGR QLAEKGHQVH IIDQRDHIGG NSYDARDSET NVMVHVYGPH 

        70         80         90        100        110        120 
IFHTDNETVW NYVNKHAEMM PYVNRVKATV NGQVFSLPIN LHTINQFFSK TCSPDEARAL 

       130        140        150        160        170        180 
IAEKGDSTIA DPQTFEEQAL RFIGKELYEA FFKGYTIKQW GMQPSELPAS ILKRLPVRFN 

       190        200        210        220        230        240 
YDDNYFNHKF QGMPKCGYTQ MIKSILNHEN IKVDLQREFI VEERTHYDHV FYSGPLDAFY 

       250        260        270        280        290        300 
GYQYGRLGYR TLDFKKFTYQ GDYQGCAVMN YCSVDVPYTR ITEHKYFSPW EQHDGSVCYK 

       310        320        330        340        350        360 
EYSRACEEND IPYYPIRQMG EMALLEKYLS LAENETNITF VGRLGTYRYL DMDVTIAEAL 

       370        380 
KTAEVYLNSL TENQPMPVFT VSVR 

« Hide

References

[1]"Role of Rfe and RfbF in the initiation of biosynthesis of D-galactan I, the lipopolysaccharide O antigen from Klebsiella pneumoniae serotype O1."
Clarke B.R., Bronner D., Keenleyside W.J., Severn W.B., Richards J.C., Whitfield C.
J. Bacteriol. 177:5411-5418(1995) [PubMed: 7559323] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K20 / Serotype O1.
+Additional computationally mapped references.

Cross-references

Sequence databases

L31762 Genomic DNA. Translation: AAC98417.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1WAMX-ray2.35A1-384[»]
2BI7X-ray2.00A1-384[»]
2BI8X-ray2.35A1-384[»]
ModBaseSearch...

Enzyme and pathway databases

BRENDA5.4.99.9. 758.

Family and domain databases

InterProIPR006076. FAD-dep_OxRdtase.
IPR016040. NAD(P)-bd_dom.
IPR004379. UDP-GALP_mutase.
IPR015899. UDP-GalPyranose_mutase_C.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF01266. DAO. 1 hit.
PF03275. GLF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00031. UDP-GALP_mutase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLF1_KLEPN
AccessionPrimary (citable) accession number: Q48485
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents