Probable UDP-galactopyranose mutase - Klebsiella pneumoniae

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Reviewed, UniProtKB/Swiss-Prot Q48485 (GLF1_KLEPN)

Last modified June 16, 2009. Version 52. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Probable UDP-galactopyranose mutase
EC=5.4.99.9

Gene names

Name:

rfbD

Organism

Klebsiella pneumoniae

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the conversion of UDP-GalP into UDP-GalF through a 2-keto intermediate.
Catalytic activity	UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose.
Cofactor	FAD By similarity.
Pathway	Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Ligand	FAD Flavoprotein
Molecular function	Isomerase
Technical term	3D-structure
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-galactopyranose mutase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

384

Probable UDP-galactopyranose mutase

PRO_0000087506

Regions

Nucleotide binding

29

FAD Potential

Secondary structure

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384

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

Q48485-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: B74EC65EA5B751AB
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384

44,457

        10         20         30         40         50         60 
MKSKKILIVG AGFSGAVIGR QLAEKGHQVH IIDQRDHIGG NSYDARDSET NVMVHVYGPH 

        70         80         90        100        110        120 
IFHTDNETVW NYVNKHAEMM PYVNRVKATV NGQVFSLPIN LHTINQFFSK TCSPDEARAL 

       130        140        150        160        170        180 
IAEKGDSTIA DPQTFEEQAL RFIGKELYEA FFKGYTIKQW GMQPSELPAS ILKRLPVRFN 

       190        200        210        220        230        240 
YDDNYFNHKF QGMPKCGYTQ MIKSILNHEN IKVDLQREFI VEERTHYDHV FYSGPLDAFY 

       250        260        270        280        290        300 
GYQYGRLGYR TLDFKKFTYQ GDYQGCAVMN YCSVDVPYTR ITEHKYFSPW EQHDGSVCYK 

       310        320        330        340        350        360 
EYSRACEEND IPYYPIRQMG EMALLEKYLS LAENETNITF VGRLGTYRYL DMDVTIAEAL 

       370        380 
KTAEVYLNSL TENQPMPVFT VSVR

References

[1]	"Role of Rfe and RfbF in the initiation of biosynthesis of D-galactan I, the lipopolysaccharide O antigen from Klebsiella pneumoniae serotype O1." Clarke B.R., Bronner D., Keenleyside W.J., Severn W.B., Richards J.C., Whitfield C. J. Bacteriol. 177:5411-5418(1995) [PubMed: 7559323] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K20 / Serotype O1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

L31762 Genomic DNA. Translation: AAC98417.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WAM	X-ray	2.35	A	1-384	[»]
2BI7	X-ray	2.00	A	1-384	[»]
2BI8	X-ray	2.35	A	1-384	[»]

ModBase

Enzyme and pathway databases

BRENDA

Family and domain databases

InterPro

IPR006076. FAD-dep_OxRdtase.
IPR016040. NAD(P)-bd_dom.
IPR004379. UDP-GALP_mutase.
IPR015899. UDP-GalPyranose_mutase_C.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.

Pfam

PF01266. DAO. 1 hit.
PF03275. GLF. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00031. UDP-GALP_mutase. 1 hit.

ProtoNet

Entry information

Entry name

GLF1_KLEPN

Accession

Primary (citable) accession number: Q48485

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents