ID   GLF8_KLEPN              Reviewed;         384 AA.
AC   Q48481;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=Probable UDP-galactopyranose mutase;
DE            EC=5.4.99.9;
GN   Name=rfbD;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Serotype O8;
RX   MEDLINE=96359375; PubMed=8752339;
RA   Kelly R.F., Whitfield C.;
RT   "Clonally diverse rfb gene clusters are involved in expression of a
RT   family of related D-galactan O antigens in Klebsiella species.";
RL   J. Bacteriol. 178:5205-5214(1996).
CC   -!- FUNCTION: Involved in the conversion of UDP-GalP into UDP-GalF
CC       through a 2-keto intermediate.
CC   -!- CATALYTIC ACTIVITY: UDP-D-galactopyranose = UDP-D-galacto-1,4-
CC       furanose.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; LPS O-antigen
CC       biosynthesis.
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DR   EMBL; L41518; AAC98408.1; -; Genomic_DNA.
DR   HSSP; P37747; 1I8T.
DR   SMR; Q48481; 3-384.
DR   BRENDA; 5.4.99.9; 758.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0008767; F:UDP-galactopyranose mutase activity; IEA:EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR004379; UDP-GALP_mutase.
DR   InterPro; IPR015899; UDP-GalPyranose_mutase_C.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 2.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   Pfam; PF03275; GLF; 1.
DR   ProDom; PD000139; FAD_pyr_redox; 1.
DR   TIGRFAMs; TIGR00031; UDP-GALP_mutase; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Isomerase; Lipopolysaccharide biosynthesis.
FT   CHAIN         1    384       Probable UDP-galactopyranose mutase.
FT                                /FTId=PRO_0000087507.
FT   NP_BIND       5     33       FAD (Potential).
SQ   SEQUENCE   384 AA;  44475 MW;  AA812676E6D060FF CRC64;
     MNNKNIMIVG AGFSGVVIAR QLAEQGYTVK IIDRRDHIGG NSYDTRDPQT DVMVHVYGPH
     IFHTDNETVW NYVNQYAEMM PYVNRVKATV NGQVFSLPIN LHTINQFFAK TCSPDEARAL
     ISEKGDSSIV EPQTFEEQAL RFIGKELYEA FFKGYTIKQW GMEPSELPAS ILKRLPVRFN
     YDDNYFNHKF QGMPKLGYTR MIEAIADHEN ISIELQREFL PEEREDYAHV FYSGPLDAFY
     SYQYGRLGYR TLDFEKFTYQ GDYQGCAVMN YCSIDVPYTR ITEHKYFSPW ESHEGSVCYK
     EYSRACGEND IPYYPIRQMG EMALLEKYLS LAESEKNITF VGRLGTYRYL DMDVTIAEAL
     KTADEFLSSV ANQEEMPVFT VPVR
//