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Q48481

- GLF8_KLEPN

UniProt

Q48481 - GLF8_KLEPN

Protein

Probable UDP-galactopyranose mutase

Gene

rfbD

Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF).By similarity

    Catalytic activityi

    UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141FADBy similarity
    Binding sitei41 – 411FAD; via amide nitrogenBy similarity
    Binding sitei84 – 841UDP-GalPBy similarity
    Binding sitei151 – 1511UDP-GalP; via carbonyl oxygenBy similarity
    Binding sitei156 – 1561UDP-GalPBy similarity
    Binding sitei160 – 1601UDP-GalPBy similarity
    Binding sitei185 – 1851UDP-GalPBy similarity
    Binding sitei219 – 2191FAD; via amide nitrogenBy similarity
    Binding sitei270 – 2701UDP-GalPBy similarity
    Binding sitei280 – 2801UDP-GalPBy similarity
    Binding sitei314 – 3141UDP-GalPBy similarity
    Binding sitei343 – 3431FADBy similarity
    Binding sitei349 – 3491UDP-GalPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi33 – 342FADBy similarity
    Nucleotide bindingi60 – 612FADBy similarity
    Nucleotide bindingi350 – 3556FADBy similarity

    GO - Molecular functioni

    1. UDP-galactopyranose mutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. O antigen biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00281.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable UDP-galactopyranose mutase (EC:5.4.99.9)
    Short name:
    UGM
    Alternative name(s):
    UDP-GALP mutase
    Uridine 5-diphosphate galactopyranose mutase
    Gene namesi
    Name:rfbD
    OrganismiKlebsiella pneumoniae
    Taxonomic identifieri573 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 384365Probable UDP-galactopyranose mutasePRO_0000087507Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ48481.
    SMRiQ48481. Positions 3-384.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.50.720. 3 hits.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR004379. UDP-GALP_mutase.
    IPR015899. UDP-GalPyranose_mutase_C.
    [Graphical view]
    PANTHERiPTHR21197. PTHR21197. 1 hit.
    PfamiPF03275. GLF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00031. UDP-GALP_mutase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q48481-1 [UniParc]FASTAAdd to Basket

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    MNNKNIMIVG AGFSGVVIAR QLAEQGYTVK IIDRRDHIGG NSYDTRDPQT    50
    DVMVHVYGPH IFHTDNETVW NYVNQYAEMM PYVNRVKATV NGQVFSLPIN 100
    LHTINQFFAK TCSPDEARAL ISEKGDSSIV EPQTFEEQAL RFIGKELYEA 150
    FFKGYTIKQW GMEPSELPAS ILKRLPVRFN YDDNYFNHKF QGMPKLGYTR 200
    MIEAIADHEN ISIELQREFL PEEREDYAHV FYSGPLDAFY SYQYGRLGYR 250
    TLDFEKFTYQ GDYQGCAVMN YCSIDVPYTR ITEHKYFSPW ESHEGSVCYK 300
    EYSRACGEND IPYYPIRQMG EMALLEKYLS LAESEKNITF VGRLGTYRYL 350
    DMDVTIAEAL KTADEFLSSV ANQEEMPVFT VPVR 384
    Length:384
    Mass (Da):44,475
    Last modified:November 1, 1997 - v1
    Checksum:iAA812676E6D060FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41518 Genomic DNA. Translation: AAC98408.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41518 Genomic DNA. Translation: AAC98408.1 .

    3D structure databases

    ProteinModelPortali Q48481.
    SMRi Q48481. Positions 3-384.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00281 .

    Family and domain databases

    Gene3Di 3.40.50.720. 3 hits.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR004379. UDP-GALP_mutase.
    IPR015899. UDP-GalPyranose_mutase_C.
    [Graphical view ]
    PANTHERi PTHR21197. PTHR21197. 1 hit.
    Pfami PF03275. GLF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00031. UDP-GALP_mutase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Clonally diverse rfb gene clusters are involved in expression of a family of related D-galactan O antigens in Klebsiella species."
      Kelly R.F., Whitfield C.
      J. Bacteriol. 178:5205-5214(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Serotype O8.

    Entry informationi

    Entry nameiGLF8_KLEPN
    AccessioniPrimary (citable) accession number: Q48481
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3