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Q48481

- GLF8_KLEPN

UniProt

Q48481 - GLF8_KLEPN

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Protein
Probable UDP-galactopyranose mutase
Gene
rfbD
Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF) By similarity.

Catalytic activityi

UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose.

Cofactori

Binds 1 FAD per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141FAD By similarity
Binding sitei41 – 411FAD; via amide nitrogen By similarity
Binding sitei84 – 841UDP-GalP By similarity
Binding sitei151 – 1511UDP-GalP; via carbonyl oxygen By similarity
Binding sitei156 – 1561UDP-GalP By similarity
Binding sitei160 – 1601UDP-GalP By similarity
Binding sitei185 – 1851UDP-GalP By similarity
Binding sitei219 – 2191FAD; via amide nitrogen By similarity
Binding sitei270 – 2701UDP-GalP By similarity
Binding sitei280 – 2801UDP-GalP By similarity
Binding sitei314 – 3141UDP-GalP By similarity
Binding sitei343 – 3431FAD By similarity
Binding sitei349 – 3491UDP-GalP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 342FAD By similarity
Nucleotide bindingi60 – 612FAD By similarity
Nucleotide bindingi350 – 3556FAD By similarity

GO - Molecular functioni

  1. UDP-galactopyranose mutase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. O antigen biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00281.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UDP-galactopyranose mutase (EC:5.4.99.9)
Short name:
UGM
Alternative name(s):
UDP-GALP mutase
Uridine 5-diphosphate galactopyranose mutase
Gene namesi
Name:rfbD
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 384365Probable UDP-galactopyranose mutase
PRO_0000087507Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ48481.
SMRiQ48481. Positions 3-384.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.720. 3 hits.
InterProiIPR016040. NAD(P)-bd_dom.
IPR004379. UDP-GALP_mutase.
IPR015899. UDP-GalPyranose_mutase_C.
[Graphical view]
PANTHERiPTHR21197. PTHR21197. 1 hit.
PfamiPF03275. GLF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00031. UDP-GALP_mutase. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q48481-1 [UniParc]FASTAAdd to Basket

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MNNKNIMIVG AGFSGVVIAR QLAEQGYTVK IIDRRDHIGG NSYDTRDPQT    50
DVMVHVYGPH IFHTDNETVW NYVNQYAEMM PYVNRVKATV NGQVFSLPIN 100
LHTINQFFAK TCSPDEARAL ISEKGDSSIV EPQTFEEQAL RFIGKELYEA 150
FFKGYTIKQW GMEPSELPAS ILKRLPVRFN YDDNYFNHKF QGMPKLGYTR 200
MIEAIADHEN ISIELQREFL PEEREDYAHV FYSGPLDAFY SYQYGRLGYR 250
TLDFEKFTYQ GDYQGCAVMN YCSIDVPYTR ITEHKYFSPW ESHEGSVCYK 300
EYSRACGEND IPYYPIRQMG EMALLEKYLS LAESEKNITF VGRLGTYRYL 350
DMDVTIAEAL KTADEFLSSV ANQEEMPVFT VPVR 384
Length:384
Mass (Da):44,475
Last modified:November 1, 1997 - v1
Checksum:iAA812676E6D060FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41518 Genomic DNA. Translation: AAC98408.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41518 Genomic DNA. Translation: AAC98408.1 .

3D structure databases

ProteinModelPortali Q48481.
SMRi Q48481. Positions 3-384.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00281 .

Family and domain databases

Gene3Di 3.40.50.720. 3 hits.
InterProi IPR016040. NAD(P)-bd_dom.
IPR004379. UDP-GALP_mutase.
IPR015899. UDP-GalPyranose_mutase_C.
[Graphical view ]
PANTHERi PTHR21197. PTHR21197. 1 hit.
Pfami PF03275. GLF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00031. UDP-GALP_mutase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Clonally diverse rfb gene clusters are involved in expression of a family of related D-galactan O antigens in Klebsiella species."
    Kelly R.F., Whitfield C.
    J. Bacteriol. 178:5205-5214(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Serotype O8.

Entry informationi

Entry nameiGLF8_KLEPN
AccessioniPrimary (citable) accession number: Q48481
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 22, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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