Reviewed, UniProtKB/Swiss-Prot Q48481 (GLF8_KLEPN)

Names and origin

Protein names

Recommended name:
    Probable UDP-galactopyranose mutase
    EC=5.4.99.9

Gene names

Name:

rfbD

Organism

Klebsiella pneumoniae

Taxonomic identifier

573 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the conversion of UDP-GalP into UDP-GalF through a 2-keto intermediate.
Catalytic activity	UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose.
Cofactor	FAD By similarity.
Pathway	Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Ligand	FAD Flavoprotein
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-galactopyranose mutase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Probable UDP-galactopyranose mutase		PRO_0000087507
Regions
	Nucleotide binding	5 – 33	29	FAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q48481-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: AA812676E6D060FF	FASTA	384	44,475
	10 20 30 40 50 60 MNNKNIMIVG AGFSGVVIAR QLAEQGYTVK IIDRRDHIGG NSYDTRDPQT DVMVHVYGPH 70 80 90 100 110 120 IFHTDNETVW NYVNQYAEMM PYVNRVKATV NGQVFSLPIN LHTINQFFAK TCSPDEARAL 130 140 150 160 170 180 ISEKGDSSIV EPQTFEEQAL RFIGKELYEA FFKGYTIKQW GMEPSELPAS ILKRLPVRFN 190 200 210 220 230 240 YDDNYFNHKF QGMPKLGYTR MIEAIADHEN ISIELQREFL PEEREDYAHV FYSGPLDAFY 250 260 270 280 290 300 SYQYGRLGYR TLDFEKFTYQ GDYQGCAVMN YCSIDVPYTR ITEHKYFSPW ESHEGSVCYK 310 320 330 340 350 360 EYSRACGEND IPYYPIRQMG EMALLEKYLS LAESEKNITF VGRLGTYRYL DMDVTIAEAL 370 380 KTADEFLSSV ANQEEMPVFT VPVR

References

[1]	"Clonally diverse rfb gene clusters are involved in expression of a family of related D-galactan O antigens in Klebsiella species." Kelly R.F., Whitfield C. J. Bacteriol. 178:5205-5214(1996) [PubMed: 8752339] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Serotype O8.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L41518 Genomic DNA. Translation: AAC98408.1.
3D structure databases
HSSP	HSSP built from PDB template 1I8T based on UniProtKB P37747.
SMR	Q48481. Positions 3-384.
ModBase	Search...
Enzyme and pathway databases
BRENDA	5.4.99.9. 758.
Family and domain databases
InterPro	IPR002937. Amino_oxidase. IPR016040. NAD(P)-bd_dom. IPR004379. UDP-GALP_mutase. IPR015899. UDP-GalPyranose_mutase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
Pfam	PF01593. Amino_oxidase. 1 hit. PF03275. GLF. 1 hit. [Graphical view]
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00031. UDP-GALP_mutase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLF8_KLEPN

Accession

Primary (citable) accession number: Q48481

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)