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Protein

Outer membrane protein C

Gene

ompC

Organism
Klebsiella pneumoniae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms pores that allow passive diffusion of small molecules across the outer membrane. In K.pneumoniae it has been shown to bind the C1Q component and activate the classical pathway of the complement system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein C
Alternative name(s):
Porin OmpC
Porin ompk36
Gene namesi
Name:ompC
Synonyms:ompK36
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000002523622 – 363Outer membrane protein CAdd BLAST342

Proteomic databases

PRIDEiQ48473.

Interactioni

Subunit structurei

Homotrimer.

Structurei

Secondary structure

1363
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi23 – 27Combined sources5
Beta strandi30 – 47Combined sources18
Turni48 – 50Combined sources3
Beta strandi56 – 66Combined sources11
Beta strandi68 – 70Combined sources3
Beta strandi72 – 82Combined sources11
Beta strandi93 – 103Combined sources11
Beta strandi109 – 116Combined sources8
Helixi120 – 123Combined sources4
Helixi124 – 126Combined sources3
Beta strandi130 – 132Combined sources3
Beta strandi144 – 157Combined sources14
Helixi158 – 160Combined sources3
Beta strandi165 – 172Combined sources8
Turni180 – 182Combined sources3
Helixi190 – 192Combined sources3
Beta strandi196 – 207Combined sources12
Beta strandi210 – 220Combined sources11
Helixi223 – 226Combined sources4
Beta strandi228 – 230Combined sources3
Beta strandi234 – 247Combined sources14
Beta strandi250 – 261Combined sources12
Beta strandi263 – 265Combined sources3
Turni266 – 268Combined sources3
Beta strandi272 – 283Combined sources12
Beta strandi288 – 301Combined sources14
Beta strandi304 – 306Combined sources3
Beta strandi308 – 324Combined sources17
Beta strandi327 – 336Combined sources10
Helixi342 – 347Combined sources6
Beta strandi354 – 363Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OSMX-ray3.20A/B/C22-363[»]
ProteinModelPortaliQ48473.
SMRiQ48473.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ48473.

Family & Domainsi

Sequence similaritiesi

Belongs to the Gram-negative porin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001897. Porin_gammaproteobac.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00183. ECOLIPORIN.
PR00182. ECOLNEIPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q48473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKVLSLLV PALLVAGAAN AAEIYNKDGN KLDLYGKIDG LHYFSDDKDV
60 70 80 90 100
DGDQTYMRLG VKGETQINDQ LTGYGQWEYN VQANNTESSS DQAWTRLAFA
110 120 130 140 150
GLKFGDAGSF DYGRNYGVVY DVTSWTDVLP EFGGDTYGSD NFLQSRANGV
160 170 180 190 200
ATYRNSDFFG LVDGLNFALQ YQGKNGSVSG EGATNNGRGA LKQNGDGFGT
210 220 230 240 250
SVTYDIFDGI SAGFAYANSK RTDDQNQLLL GEGDHAETYT GGLKYDANNI
260 270 280 290 300
YLATQYTQTY NATRAGSLGF ANKAQNFEVA AQYQFDFGLR PSVAYLQSKG
310 320 330 340 350
KDLNGYGDQD ILKYVDVGAT YYFNKNMSTY VDYKINLLDD NSFTRSAGIS
360
TDDVVALGLV YQF
Length:363
Mass (Da):39,663
Last modified:November 1, 1996 - v1
Checksum:i9DE45546F01F116C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33506 Genomic DNA. Translation: CAA83913.1.
PIRiS51104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33506 Genomic DNA. Translation: CAA83913.1.
PIRiS51104.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OSMX-ray3.20A/B/C22-363[»]
ProteinModelPortaliQ48473.
SMRiQ48473.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ48473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ48473.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001897. Porin_gammaproteobac.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00183. ECOLIPORIN.
PR00182. ECOLNEIPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMPC_KLEPN
AccessioniPrimary (citable) accession number: Q48473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.