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Protein

Outer membrane protein C

Gene

ompC

Organism
Klebsiella pneumoniae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms pores that allow passive diffusion of small molecules across the outer membrane. In K.pneumoniae it has been shown to bind the C1Q component and activate the classical pathway of the complement system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein C
Alternative name(s):
Porin OmpC
Porin ompk36
Gene namesi
Name:ompC
Synonyms:ompK36
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 363342Outer membrane protein CPRO_0000025236Add
BLAST

Proteomic databases

PRIDEiQ48473.

Interactioni

Subunit structurei

Homotrimer.

Structurei

Secondary structure

1
363
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 275Combined sources
Beta strandi30 – 4718Combined sources
Turni48 – 503Combined sources
Beta strandi56 – 6611Combined sources
Beta strandi68 – 703Combined sources
Beta strandi72 – 8211Combined sources
Beta strandi93 – 10311Combined sources
Beta strandi109 – 1168Combined sources
Helixi120 – 1234Combined sources
Helixi124 – 1263Combined sources
Beta strandi130 – 1323Combined sources
Beta strandi144 – 15714Combined sources
Helixi158 – 1603Combined sources
Beta strandi165 – 1728Combined sources
Turni180 – 1823Combined sources
Helixi190 – 1923Combined sources
Beta strandi196 – 20712Combined sources
Beta strandi210 – 22011Combined sources
Helixi223 – 2264Combined sources
Beta strandi228 – 2303Combined sources
Beta strandi234 – 24714Combined sources
Beta strandi250 – 26112Combined sources
Beta strandi263 – 2653Combined sources
Turni266 – 2683Combined sources
Beta strandi272 – 28312Combined sources
Beta strandi288 – 30114Combined sources
Beta strandi304 – 3063Combined sources
Beta strandi308 – 32417Combined sources
Beta strandi327 – 33610Combined sources
Helixi342 – 3476Combined sources
Beta strandi354 – 36310Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OSMX-ray3.20A/B/C22-363[»]
ProteinModelPortaliQ48473.
SMRiQ48473. Positions 22-363.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ48473.

Family & Domainsi

Sequence similaritiesi

Belongs to the Gram-negative porin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001897. Porin_gammaproteobac.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00183. ECOLIPORIN.
PR00182. ECOLNEIPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q48473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKVLSLLV PALLVAGAAN AAEIYNKDGN KLDLYGKIDG LHYFSDDKDV
60 70 80 90 100
DGDQTYMRLG VKGETQINDQ LTGYGQWEYN VQANNTESSS DQAWTRLAFA
110 120 130 140 150
GLKFGDAGSF DYGRNYGVVY DVTSWTDVLP EFGGDTYGSD NFLQSRANGV
160 170 180 190 200
ATYRNSDFFG LVDGLNFALQ YQGKNGSVSG EGATNNGRGA LKQNGDGFGT
210 220 230 240 250
SVTYDIFDGI SAGFAYANSK RTDDQNQLLL GEGDHAETYT GGLKYDANNI
260 270 280 290 300
YLATQYTQTY NATRAGSLGF ANKAQNFEVA AQYQFDFGLR PSVAYLQSKG
310 320 330 340 350
KDLNGYGDQD ILKYVDVGAT YYFNKNMSTY VDYKINLLDD NSFTRSAGIS
360
TDDVVALGLV YQF
Length:363
Mass (Da):39,663
Last modified:November 1, 1996 - v1
Checksum:i9DE45546F01F116C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33506 Genomic DNA. Translation: CAA83913.1.
PIRiS51104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z33506 Genomic DNA. Translation: CAA83913.1.
PIRiS51104.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OSMX-ray3.20A/B/C22-363[»]
ProteinModelPortaliQ48473.
SMRiQ48473. Positions 22-363.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ48473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ48473.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001897. Porin_gammaproteobac.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00183. ECOLIPORIN.
PR00182. ECOLNEIPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMPC_KLEPN
AccessioniPrimary (citable) accession number: Q48473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 14, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.