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Protein

Biosynthetic peptidoglycan transglycosylase

Gene

mtgA

Organism
Klebsiella oxytoca
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.UniRule annotation

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic peptidoglycan transglycosylaseUniRule annotation (EC:2.4.1.129UniRule annotation)
Alternative name(s):
Glycan polymeraseUniRule annotation
Monofunctional biosynthetic peptidoglycan transglycosylase1 Publication
Peptidoglycan glycosyltransferase MtgAUniRule annotation
Short name:
PGTUniRule annotation
Gene namesi
Name:mtgAUniRule annotation
OrganismiKlebsiella oxytoca
Taxonomic identifieri571 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000831291 – 242Biosynthetic peptidoglycan transglycosylaseAdd BLAST242

Structurei

3D structure databases

ProteinModelPortaliQ48465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 51 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.3810.10. 1 hit.
HAMAPiMF_00766. PGT_MtgA. 1 hit.
InterProiView protein in InterPro
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011812. Mono_pep_trsgly.
PfamiView protein in Pfam
PF00912. Transgly. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
TIGRFAMsiTIGR02070. mono_pep_trsgly. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48465-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFRFSARCR LIKRFLLRLL LACAVLWGGG VALFSIVPVP FSAVMLERQL
60 70 80 90 100
GAWLSGNFHY IAHSDWVGMD EISPWMGLAV IAAEDQKFPE HWGFDVPAIE
110 120 130 140 150
KALAHNERNE NRIRGASTLS QQTAKNLFLW DGRSWLRKGL EAGLTVGIET
160 170 180 190 200
VWSKKRILTV YLNIAEFGEG TFGVEAASQR YFHKPASRLT AAEAALLAAV
210 220 230 240
LPNPIRFRAD APSGYIRSRQ AWILRQMRQL GGEGFMRANQ LH
Length:242
Mass (Da):27,197
Last modified:November 1, 1997 - v1
Checksum:iA12CAB4A331ABA49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54198 Genomic DNA. Translation: CAA90903.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z54198 Genomic DNA. Translation: CAA90903.1.

3D structure databases

ProteinModelPortaliQ48465.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

Gene3Di1.10.3810.10. 1 hit.
HAMAPiMF_00766. PGT_MtgA. 1 hit.
InterProiView protein in InterPro
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR011812. Mono_pep_trsgly.
PfamiView protein in Pfam
PF00912. Transgly. 1 hit.
SUPFAMiSSF53955. SSF53955. 1 hit.
TIGRFAMsiTIGR02070. mono_pep_trsgly. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTGA_KLEOX
AccessioniPrimary (citable) accession number: Q48465
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 15, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.