Q48463 (MANB_KLEPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphomannomutase
Short name=PMM
EC=5.4.2.8

Alternative name(s):
ORF17

Gene names

Name:	manB
Synonyms:	cpsG

Organism

Klebsiella pneumoniae

Taxonomic identifier

573 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	157 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of the K2 capsular polysaccharide biosynthesis.
Catalytic activity	Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2. Capsule biogenesis; capsule polysaccharide biosynthesis.
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Lipopolysaccharide biosynthesis
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	GDP-mannose biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphomannomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›157	›157	Phosphomannomutase		PRO_0000147820
Sites
	Active site	98	1	Phosphoserine intermediate By similarity
	Metal binding	98	1	Magnesium; via phosphate group By similarity
Experimental info
	Non-terminal residue	157	1

Sequences

	Sequence		Length	Mass (Da)
	Q48463 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 6AC0F03089741D95	FASTA	157	17,234
	10 20 30 40 50 60 MTQLTCFKAY DIRGELGEEL NEDIAYRIGR AYGEFLKPGK IVVGGDVRLT SESLNVALAR 70 80 90 100 110 120 GLMDAGTDVL DIGLSGTEEI YFATFHLGVD GGIEVTASHN PMNYNGMKLV RENAKPISGD 130 140 150 TGLRDIQRLA EENQFPPVDP ARRGTLRQIS VLKEYVD

References

[1]

"Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid." Arakawa Y., Wacharotayankun R., Nagatsuka T., Ito H., Kato N., Ohta M. J. Bacteriol. 177:1788-1796(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Chedid.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D21242 Genomic DNA. Translation: BAA04788.1.
PIR	F56146.
3D structure databases
ProteinModelPortal	Q48463.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00126; UER00424. UPA00934.
Family and domain databases
Gene3D	3.40.120.10. 1 hit.
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR016066. A-D-PHexomutase_CS. [Graphical view]
Pfam	PF02878. PGM_PMM_I. 1 hit. [Graphical view]
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MANB_KLEPN

Accession

Primary (citable) accession number: Q48463

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program