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Q48463 (MANB_KLEPN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphomannomutase

Short name=PMM
EC=5.4.2.8
Alternative name(s):
ORF17
Gene names
Name:manB
Synonyms:cpsG
OrganismKlebsiella pneumoniae
Taxonomic identifier573 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length157 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the K2 capsular polysaccharide biosynthesis.

Catalytic activity

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Capsule biogenesis; capsule polysaccharide biosynthesis.

Sequence similarities

Belongs to the phosphohexose mutase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›157›157Phosphomannomutase
PRO_0000147820

Sites

Active site981Phosphoserine intermediate By similarity
Metal binding981Magnesium; via phosphate group By similarity

Experimental info

Non-terminal residue1571

Sequences

Sequence LengthMass (Da)Tools
Q48463 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 6AC0F03089741D95

FASTA15717,234
        10         20         30         40         50         60 
MTQLTCFKAY DIRGELGEEL NEDIAYRIGR AYGEFLKPGK IVVGGDVRLT SESLNVALAR 

        70         80         90        100        110        120 
GLMDAGTDVL DIGLSGTEEI YFATFHLGVD GGIEVTASHN PMNYNGMKLV RENAKPISGD 

       130        140        150 
TGLRDIQRLA EENQFPPVDP ARRGTLRQIS VLKEYVD 

« Hide

References

[1]"Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid."
Arakawa Y., Wacharotayankun R., Nagatsuka T., Ito H., Kato N., Ohta M.
J. Bacteriol. 177:1788-1796(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Chedid.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D21242 Genomic DNA. Translation: BAA04788.1.
PIRF56146.

3D structure databases

ProteinModelPortalQ48463.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00126; UER00424.
UPA00934.

Family and domain databases

Gene3D3.40.120.10. 1 hit.
InterProIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR016066. A-D-PHexomutase_CS.
[Graphical view]
PfamPF02878. PGM_PMM_I. 1 hit.
[Graphical view]
SUPFAMSSF53738. SSF53738. 1 hit.
PROSITEPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMANB_KLEPN
AccessionPrimary (citable) accession number: Q48463
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 16, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways