Reviewed,
UniProtKB/Swiss-Prot Q48463 (MANB_KLEPN)
Last modified
June 16, 2009.
Version 53.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Phosphomannomutase Short name=PMM EC=5.4.2.8 Alternative name(s): ORF17 | ||||
| Gene names |
| ||||
| Organism | Klebsiella pneumoniae | ||||
| Taxonomic identifier | 573 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella |
Protein attributes
| Sequence length | 157 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Involved in the biosynthesis of the K2 capsular polysaccharide biosynthesis. |
| Catalytic activity | Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate. |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. |
| Pathway | |
| Sequence similarities | Belongs to the phosphohexose mutase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Capsule biogenesis/degradation Lipopolysaccharide biosynthesis |
| Ligand | Magnesium Metal-binding |
| Molecular function | Isomerase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphomannomutase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – ›157 | ›157 | Phosphomannomutase | PRO_0000147820 | |||||
Sites | |||||||||
| Active site | 98 | 1 | Phosphoserine intermediate By similarity | ||||||
| Metal binding | 98 | 1 | Magnesium; via phosphate group By similarity | ||||||
Experimental info | |||||||||
| Non-terminal residue | 157 | 1 | |||||||
Sequences
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References
| [1] | "Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid." Arakawa Y., Wacharotayankun R., Nagatsuka T., Ito H., Kato N., Ohta M. J. Bacteriol. 177:1788-1796(1995) [PubMed: 7896702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Chedid. |
Cross-references
Sequence databases | |
|---|---|
| D21242 Genomic DNA. Translation: BAA04788.1. | |
| PIR | F56146. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1K35 based on UniProtKB P26276. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 5.4.2.8. 758. |
Family and domain databases | |
| InterPro | IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR016066. A-D-PHexomutase_CS. [Graphical view] |
| Gene3D | G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 1 hit. |
| Pfam | PF02878. PGM_PMM_I. 1 hit. [Graphical view] |
| PROSITE | PS00710. PGM_PMM. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MANB_KLEPN | ||||||||
| Accession | Primary (citable) accession number: Q48463 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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