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Q48463

- MANB_KLEPN

UniProt

Q48463 - MANB_KLEPN

Protein

Phosphomannomutase

Gene

manB

Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Involved in the biosynthesis of the K2 capsular polysaccharide biosynthesis.

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Cofactori

    Binds 1 magnesium ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei98 – 981Phosphoserine intermediateBy similarity
    Metal bindingi98 – 981Magnesium; via phosphate groupBy similarity

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
    2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    3. lipopolysaccharide biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Capsule biogenesis/degradation, Lipopolysaccharide biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00126; UER00424.
    UPA00934.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphomannomutase (EC:5.4.2.8)
    Short name:
    PMM
    Alternative name(s):
    ORF17
    Gene namesi
    Name:manB
    Synonyms:cpsG
    OrganismiKlebsiella pneumoniae
    Taxonomic identifieri573 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›157›157PhosphomannomutasePRO_0000147820Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ48463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphohexose mutase family.Curated

    Family and domain databases

    Gene3Di3.40.120.10. 1 hit.
    InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR016066. A-D-PHexomutase_CS.
    [Graphical view]
    PfamiPF02878. PGM_PMM_I. 1 hit.
    [Graphical view]
    SUPFAMiSSF53738. SSF53738. 1 hit.
    PROSITEiPS00710. PGM_PMM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q48463-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQLTCFKAY DIRGELGEEL NEDIAYRIGR AYGEFLKPGK IVVGGDVRLT    50
    SESLNVALAR GLMDAGTDVL DIGLSGTEEI YFATFHLGVD GGIEVTASHN 100
    PMNYNGMKLV RENAKPISGD TGLRDIQRLA EENQFPPVDP ARRGTLRQIS 150
    VLKEYVD 157
    Length:157
    Mass (Da):17,234
    Last modified:November 1, 1997 - v1
    Checksum:i6AC0F03089741D95
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei157 – 1571

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21242 Genomic DNA. Translation: BAA04788.1.
    PIRiF56146.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21242 Genomic DNA. Translation: BAA04788.1 .
    PIRi F56146.

    3D structure databases

    ProteinModelPortali Q48463.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .
    UPA00934 .

    Family and domain databases

    Gene3Di 3.40.120.10. 1 hit.
    InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
    IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
    IPR016066. A-D-PHexomutase_CS.
    [Graphical view ]
    Pfami PF02878. PGM_PMM_I. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53738. SSF53738. 1 hit.
    PROSITEi PS00710. PGM_PMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid."
      Arakawa Y., Wacharotayankun R., Nagatsuka T., Ito H., Kato N., Ohta M.
      J. Bacteriol. 177:1788-1796(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Chedid.

    Entry informationi

    Entry nameiMANB_KLEPN
    AccessioniPrimary (citable) accession number: Q48463
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3