Q48462 (MANC_KLEPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanylyltransferase
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase
Short name=GMP
Short name=GMPP
ORF16

Gene names

Name:	manC
Synonyms:	cpsB

Organism

Klebsiella pneumoniae

Taxonomic identifier

573 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of the K2 capsular polysaccharide biosynthesis.
Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the mannose-6-phosphate isomerase type 2 family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Lipopolysaccharide biosynthesis
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	Mannose-1-phosphate guanylyltransferase		PRO_0000194255

Sequences

	Sequence		Length	Mass (Da)
	Q48462 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: B3F46092D767D9E5	FASTA	471	52,864
	10 20 30 40 50 60 MLLPVIMAGG TGSRLWPMSR ELYPKQFLRL FGQNSMLQET ITRLSGLEIH EPMVICNEEH 70 80 90 100 110 120 RFLVAEQLRQ LNKLSNNIIL EPVGRNTAPA IALAALQATR HGDDPLMLVL AADHIINNQP 130 140 150 160 170 180 VFHDAIRVAE QYADEGHLVT FGIVPNAPET GYGYIQRGVA LTDSAHTPYQ VARFVEKPDR 190 200 210 220 230 240 ERAEAYLASG EYYWNSGMFM FRAKKYLSEL AKFRPDILEA CQAAVNAADN GSDFISIPHD 250 260 270 280 290 300 IFCECPDESV DYAVMEKTAD AVVVGLDADW SDVGSWSALW EVSPKDEQGN VLSGDAWVHN 310 320 330 340 350 360 SENCYINSDE KLVAAIGVEN LVIVSTKDAV LVMNRERSQD VKKAVEFLKQ NQRSEYKRHR 370 380 390 400 410 420 EIYRPWGRCD VVVQTPRFNV NRITVKPGGA FSMQMHHHRA EHWVILAGTG QVTVNGKQFL 430 440 450 460 470 LTENQSTFIP IGAEHSLENP GRIPLEVLEI QSGSYLGEDD IIRIKDQYGR C

References

[1]

"Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid." Arakawa Y., Wacharotayankun R., Nagatsuka T., Ito H., Kato N., Ohta M. J. Bacteriol. 177:1788-1796(1995) [PubMed: 7896702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Chedid.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D21242 Genomic DNA. Translation: BAA04787.1.
PIR	E56146.
3D structure databases
ProteinModelPortal	Q48462.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR011051. Cupin_RmlC_type. IPR006375. Man1P_GuaTrfase/Man6P_Isoase. IPR001538. Man6P_isomerase-2_C. IPR005835. NTP_transferase. IPR014710. RmlC-like_jellyroll. [Graphical view]
Gene3D	G3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit.
Pfam	PF01050. MannoseP_isomer. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMs	TIGR01479. GMP_PMI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MANC_KLEPN

Accession

Primary (citable) accession number: Q48462

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	September 21, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program