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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

galF

Organism
Klebsiella pneumoniae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathway:inucleotide-sugar metabolism

This protein is involved in the pathway nucleotide-sugar metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway nucleotide-sugar metabolism and in Carbohydrate metabolism.

Pathway:icapsule polysaccharide biosynthesis

This protein is involved in the pathway capsule polysaccharide biosynthesis, which is part of Capsule biogenesis.
View all proteins of this organism that are known to be involved in the pathway capsule polysaccharide biosynthesis and in Capsule biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Capsule biogenesis/degradation, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00215.
UPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:galF
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298UTP--glucose-1-phosphate uridylyltransferasePRO_0000201348Add
BLAST

Proteomic databases

PRIDEiQ48447.

Interactioni

Protein-protein interaction databases

STRINGi272620.KPN_02515.

Structurei

3D structure databases

ProteinModelPortaliQ48447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

KOiK00963.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01105. galF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMANLKAVI PVAGLGMHML PATKAIPKEM LPIVDKPMIQ YIVDEIVAAG
60 70 80 90 100
IKEIVLVTHS SKNAVENHFD TSYELEALLE QRVKRQLLAE VQAICPPGVT
110 120 130 140 150
IMNVRQAQPL GLGHSILCAR PVVGDNPFVV VLPDIILDGG TADPLRYNLA
160 170 180 190 200
AMIARFNETG RSQVLAKRMP GDLSEYSVIQ TKEPMVAEGQ VARIVEFIEK
210 220 230 240 250
PDEPQTLDSD LMAVGRYVLS ADIWAELERT EPGAWGRIQL TDAIAELAKK
260 270 280 290
QSVDAMLMTG ESYDCGKKMG YMQAFVTYGM RNLKEGAKFR ESIKKLLA
Length:298
Mass (Da):32,778
Last modified:November 1, 1997 - v1
Checksum:iC4E5DD3C3E12CE44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21242 Genomic DNA. Translation: BAA04772.1.
PIRiA56146.
RefSeqiWP_001055540.1. NZ_LART01000080.1.

Genome annotation databases

KEGGikpr:KPR_1582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21242 Genomic DNA. Translation: BAA04772.1.
PIRiA56146.
RefSeqiWP_001055540.1. NZ_LART01000080.1.

3D structure databases

ProteinModelPortaliQ48447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_02515.

Proteomic databases

PRIDEiQ48447.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGikpr:KPR_1582.

Phylogenomic databases

KOiK00963.

Enzyme and pathway databases

UniPathwayiUPA00215.
UPA00934.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01105. galF. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid."
    Arakawa Y., Wacharotayankun R., Nagatsuka T., Ito H., Kato N., Ohta M.
    J. Bacteriol. 177:1788-1796(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Chedid.

Entry informationi

Entry nameiGALF_KLEPN
AccessioniPrimary (citable) accession number: Q48447
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 22, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.