Reviewed, UniProtKB/Swiss-Prot Q48447 (GALF_KLEPN)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase
      Short name=UDPGP
    Alpha-D-glucosyl-1-phosphate uridylyltransferase
    Uridine diphosphoglucose pyrophosphorylase

Gene names

Name:

galF

Organism

Klebsiella pneumoniae

Taxonomic identifier

573 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	298 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Carbohydrate metabolism; nucleotide-sugar metabolism. Capsule biogenesis; capsule polysaccharide biosynthesis.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Lipopolysaccharide biosynthesis
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC enzyme regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 298	298	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000201348

Sequences

	Sequence		Length	Mass (Da)
	Q48447-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C4E5DD3C3E12CE44	FASTA	298	32,778
	10 20 30 40 50 60 MNMANLKAVI PVAGLGMHML PATKAIPKEM LPIVDKPMIQ YIVDEIVAAG IKEIVLVTHS 70 80 90 100 110 120 SKNAVENHFD TSYELEALLE QRVKRQLLAE VQAICPPGVT IMNVRQAQPL GLGHSILCAR 130 140 150 160 170 180 PVVGDNPFVV VLPDIILDGG TADPLRYNLA AMIARFNETG RSQVLAKRMP GDLSEYSVIQ 190 200 210 220 230 240 TKEPMVAEGQ VARIVEFIEK PDEPQTLDSD LMAVGRYVLS ADIWAELERT EPGAWGRIQL 250 260 270 280 290 TDAIAELAKK QSVDAMLMTG ESYDCGKKMG YMQAFVTYGM RNLKEGAKFR ESIKKLLA

References

[1]

"Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid." Arakawa Y., Wacharotayankun R., Nagatsuka T., Ito H., Kato N., Ohta M. J. Bacteriol. 177:1788-1796(1995) [PubMed: 7896702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Chedid.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D21242 Genomic DNA. Translation: BAA04772.1.
PIR	A56146.
3D structure databases
SMR	Q48447. Positions 6-298.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.7.9. 758.
Family and domain databases
InterPro	IPR005774. GalF. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01105. galF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GALF_KLEPN

Accession

Primary (citable) accession number: Q48447

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	February 9, 2010
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)