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Q48447

- GALF_KLEPN

UniProt

Q48447 - GALF_KLEPN

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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene
galF
Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. enzyme regulator activity Source: InterPro
  2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
  2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW
  3. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Capsule biogenesis/degradation, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00215.
UPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:galF
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298UTP--glucose-1-phosphate uridylyltransferasePRO_0000201348Add
BLAST

Proteomic databases

PRIDEiQ48447.

Structurei

3D structure databases

ProteinModelPortaliQ48447.

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01105. galF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q48447-1 [UniParc]FASTAAdd to Basket

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MNMANLKAVI PVAGLGMHML PATKAIPKEM LPIVDKPMIQ YIVDEIVAAG    50
IKEIVLVTHS SKNAVENHFD TSYELEALLE QRVKRQLLAE VQAICPPGVT 100
IMNVRQAQPL GLGHSILCAR PVVGDNPFVV VLPDIILDGG TADPLRYNLA 150
AMIARFNETG RSQVLAKRMP GDLSEYSVIQ TKEPMVAEGQ VARIVEFIEK 200
PDEPQTLDSD LMAVGRYVLS ADIWAELERT EPGAWGRIQL TDAIAELAKK 250
QSVDAMLMTG ESYDCGKKMG YMQAFVTYGM RNLKEGAKFR ESIKKLLA 298
Length:298
Mass (Da):32,778
Last modified:November 1, 1997 - v1
Checksum:iC4E5DD3C3E12CE44
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D21242 Genomic DNA. Translation: BAA04772.1.
PIRiA56146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D21242 Genomic DNA. Translation: BAA04772.1 .
PIRi A56146.

3D structure databases

ProteinModelPortali Q48447.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q48447.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00215 .
UPA00934 .

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01105. galF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid."
    Arakawa Y., Wacharotayankun R., Nagatsuka T., Ito H., Kato N., Ohta M.
    J. Bacteriol. 177:1788-1796(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Chedid.

Entry informationi

Entry nameiGALF_KLEPN
AccessioniPrimary (citable) accession number: Q48447
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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