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Q48447

- GALF_KLEPN

UniProt

Q48447 - GALF_KLEPN

Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

galF

Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Pathwayi

    GO - Molecular functioni

    1. enzyme regulator activity Source: InterPro
    2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
    2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW
    3. UDP-glucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Capsule biogenesis/degradation, Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00215.
    UPA00934.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
    Alternative name(s):
    Alpha-D-glucosyl-1-phosphate uridylyltransferase
    UDP-glucose pyrophosphorylase
    Short name:
    UDPGP
    Uridine diphosphoglucose pyrophosphorylase
    Gene namesi
    Name:galF
    OrganismiKlebsiella pneumoniae
    Taxonomic identifieri573 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298UTP--glucose-1-phosphate uridylyltransferasePRO_0000201348Add
    BLAST

    Proteomic databases

    PRIDEiQ48447.

    Structurei

    3D structure databases

    ProteinModelPortaliQ48447.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDPGP type 2 family.Curated

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR005774. GalF.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR01105. galF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q48447-1 [UniParc]FASTAAdd to Basket

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    MNMANLKAVI PVAGLGMHML PATKAIPKEM LPIVDKPMIQ YIVDEIVAAG    50
    IKEIVLVTHS SKNAVENHFD TSYELEALLE QRVKRQLLAE VQAICPPGVT 100
    IMNVRQAQPL GLGHSILCAR PVVGDNPFVV VLPDIILDGG TADPLRYNLA 150
    AMIARFNETG RSQVLAKRMP GDLSEYSVIQ TKEPMVAEGQ VARIVEFIEK 200
    PDEPQTLDSD LMAVGRYVLS ADIWAELERT EPGAWGRIQL TDAIAELAKK 250
    QSVDAMLMTG ESYDCGKKMG YMQAFVTYGM RNLKEGAKFR ESIKKLLA 298
    Length:298
    Mass (Da):32,778
    Last modified:November 1, 1997 - v1
    Checksum:iC4E5DD3C3E12CE44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21242 Genomic DNA. Translation: BAA04772.1.
    PIRiA56146.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21242 Genomic DNA. Translation: BAA04772.1 .
    PIRi A56146.

    3D structure databases

    ProteinModelPortali Q48447.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q48447.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00215 .
    UPA00934 .

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR005774. GalF.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR01105. galF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization of the Klebsiella pneumoniae cps region responsible for serotype K2 capsular polysaccharide synthesis in the virulent strain Chedid."
      Arakawa Y., Wacharotayankun R., Nagatsuka T., Ito H., Kato N., Ohta M.
      J. Bacteriol. 177:1788-1796(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Chedid.

    Entry informationi

    Entry nameiGALF_KLEPN
    AccessioniPrimary (citable) accession number: Q48447
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3