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Protein

Dihydrolipoyl dehydrogenase

Gene

acoD

Organism
Klebsiella pneumoniae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:acoDImported
Synonyms:lpdAImported
ORF Names:C3483_21115Imported
OrganismiKlebsiella pneumoniaeImported
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000238332 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

ProteinModelPortaliQ48419
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 325FAD/NAD-binding_domInterPro annotationAdd BLAST321
Domaini346 – 454Pyr_redox_dimInterPro annotationAdd BLAST109

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006258 Lipoamide_DH
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01350 lipoamide_DH, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q48419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHDKYDVLII GGGPGGYVAA IRAGQLGLRT VLVEKQHLGG ICLNWGCIPT
60 70 80 90 100
KALLHGAEVA HTITHASQLG ISVGEVNVDL QKLVQFSRTV SQQLTAGVAY
110 120 130 140 150
LLKKNGVRVI DGTARLRGKG QITVEDARGE ARDYRADHVI LATGARPRAL
160 170 180 190 200
PGIAPDGEHI WTYFEALRPK LLPKSLLIIG SGAIGVEFAS LYNDLGCKVT
210 220 230 240 250
LVELASQILP VEDAEVSAAV RKSFEKRGIQ IHTQTLVTQV QLTDTGVRCT
260 270 280 290 300
LNNTGGEYSQ DVERVLLAVG VQPNIEDLGL ETLGVELDRG FIKTDAACRT
310 320 330 340 350
NVFGLYAIGD VAGPPCLAHK ASHEGVLCVE TLAGVEGAHP LDRDYVPGCT
360 370 380 390 400
YARPQVASLG LTESTALARG RPIRIGKFSY QSNGKALVSG ETEGFVKTIF
410 420 430 440 450
DAETGELLGA HMVGAQVTEQ IQGFGIARHL EATDESLLSM IFAHPTLSEA
460
MHESILAACD QPLHQ
Length:465
Mass (Da):49,568
Last modified:July 5, 2004 - v3
Checksum:i064A892F2DC2865F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30887 Genomic DNA Translation: AAB40885.1
CP026586 Genomic DNA Translation: AVB73701.1
PIRiJC4793
RefSeqiWP_004213873.1, NZ_FLXN01000002.1

Similar proteinsi

Entry informationi

Entry nameiQ48419_KLEPN
AccessioniPrimary (citable) accession number: Q48419
Secondary accession number(s): Q48410
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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