Reviewed, UniProtKB/Swiss-Prot Q483H8 (HISX2_COLP3)

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase 2
      Short name=HDH 2
    EC=1.1.1.23

Gene names

Name:	hisD2
Ordered Locus Names:	CPS_2061

Organism

Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]

Taxonomic identifier

167879 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP MF_01024
Catalytic activity	L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024
Sequence similarities	Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Histidinol dehydrogenase 2 HAMAP MF_01024		PRO_0000135758
Sites
	Active site	334	1	Proton acceptor By similarity
	Active site	335	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q483H8-1 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 4B8C883BF8A096FA	FASTA	446	48,236
	10 20 30 40 50 60 MTHKVKIHRL SDLSAEQRNK LLQRTESNLD NFIDIVKPII ENVKLNGDKA LSEYAKKFDK 70 80 90 100 110 120 AEVSTDQIQV TQAEFDEAFT LVDEEVIQTL SYSIDNIKKF HEAQMPEEMW MKQIRPGCYA 130 140 150 160 170 180 GDRFTPINAV ACYIPRGKGS FPSVAIMTAV PAIVAGVPTA IIITPPGTDG KVDAATLVVA 190 200 210 220 230 240 KLVGIDKVFK CGGAQGIAAV AYGTNTVPKC DKVVGPGSPF VVAAKKLLAD IIHPGTPAGP 250 260 270 280 290 300 SEAIVLADDT ANPKLAALDL LVEAEHGPDS SAFLVTNSKE LAEQAQVAIN EYWQHMDRLR 310 320 330 340 350 360 VDFSSTVLSG DNGGIVLTST FEEAVDFCND YAAEHLLILS KSPFDHLGKI INAGEILLGE 370 380 390 400 410 420 NTPISIANYT LGPNAVLPTS MAAKTASPLS VFDYLKSCSI GYLTREGYEE LAPHTYRFAK 430 440 YEGFDAHANA VSHLRDEAIK SEKKIK

References

[1]

"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses." Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000083 Genomic DNA. Translation: AAZ25938.1.
RefSeq	YP_268789.1.
3D structure databases
SMR	Q483H8. Positions 6-442.
ModBase	Search...
Protein-protein interaction databases
STRING	Q483H8.
Genome annotation databases
GeneID	3520186.
GenomeReviews	Gene locus CPS_2061 in contig CP000083_GR.
KEGG	cps:CPS_2061.
NMPDR	fig|167879.3.peg.1975.
TIGR	CPS_2061.
Phylogenomic databases
eggNOG	COG0141.
HOGENOM	HBG329596.
OMA	KIVGPGS.
Enzyme and pathway databases
BioCyc	CPSY167879:CPS_2061-MONOMER.
Family and domain databases
HAMAP	MF_01024. HisD. Divergent sequence. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR001692. Histidinol_DH_CS. IPR012131. Hstdl_DH_prok-type. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX2_COLP3

Accession

Primary (citable) accession number: Q483H8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	September 13, 2005
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)