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Q483H8

- HISX2_COLP3

UniProt

Q483H8 - HISX2_COLP3

Protein

Histidinol dehydrogenase 2

Gene

hisD2

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei334 – 3341Proton acceptorUniRule annotation
    Active sitei335 – 3351Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciCPSY167879:GI48-2061-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 2UniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDH 2UniRule annotation
    Gene namesi
    Name:hisD2UniRule annotation
    Ordered Locus Names:CPS_2061
    OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
    Taxonomic identifieri167879 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
    ProteomesiUP000000547: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Histidinol dehydrogenase 2PRO_0000135758Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi167879.CPS_2061.

    Structurei

    3D structure databases

    ProteinModelPortaliQ483H8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiVAINEYW.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q483H8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHKVKIHRL SDLSAEQRNK LLQRTESNLD NFIDIVKPII ENVKLNGDKA    50
    LSEYAKKFDK AEVSTDQIQV TQAEFDEAFT LVDEEVIQTL SYSIDNIKKF 100
    HEAQMPEEMW MKQIRPGCYA GDRFTPINAV ACYIPRGKGS FPSVAIMTAV 150
    PAIVAGVPTA IIITPPGTDG KVDAATLVVA KLVGIDKVFK CGGAQGIAAV 200
    AYGTNTVPKC DKVVGPGSPF VVAAKKLLAD IIHPGTPAGP SEAIVLADDT 250
    ANPKLAALDL LVEAEHGPDS SAFLVTNSKE LAEQAQVAIN EYWQHMDRLR 300
    VDFSSTVLSG DNGGIVLTST FEEAVDFCND YAAEHLLILS KSPFDHLGKI 350
    INAGEILLGE NTPISIANYT LGPNAVLPTS MAAKTASPLS VFDYLKSCSI 400
    GYLTREGYEE LAPHTYRFAK YEGFDAHANA VSHLRDEAIK SEKKIK 446
    Length:446
    Mass (Da):48,236
    Last modified:September 13, 2005 - v1
    Checksum:i4B8C883BF8A096FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000083 Genomic DNA. Translation: AAZ25938.1.
    RefSeqiYP_268789.1. NC_003910.7.

    Genome annotation databases

    EnsemblBacteriaiAAZ25938; AAZ25938; CPS_2061.
    GeneIDi3520186.
    KEGGicps:CPS_2061.
    PATRICi21467245. VBIColPsy94388_1863.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000083 Genomic DNA. Translation: AAZ25938.1 .
    RefSeqi YP_268789.1. NC_003910.7.

    3D structure databases

    ProteinModelPortali Q483H8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 167879.CPS_2061.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ25938 ; AAZ25938 ; CPS_2061 .
    GeneIDi 3520186.
    KEGGi cps:CPS_2061.
    PATRICi 21467245. VBIColPsy94388_1863.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi VAINEYW.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci CPSY167879:GI48-2061-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 34H / ATCC BAA-681.

    Entry informationi

    Entry nameiHISX2_COLP3
    AccessioniPrimary (citable) accession number: Q483H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3