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Q483H8

- HISX2_COLP3

UniProt

Q483H8 - HISX2_COLP3

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Protein
Histidinol dehydrogenase 2
Gene
hisD2, CPS_2061
Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei334 – 3341Proton acceptor By similarity
Active sitei335 – 3351Proton acceptor By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCPSY167879:GI48-2061-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 2 (EC:1.1.1.23)
Short name:
HDH 2
Gene namesi
Name:hisD2
Ordered Locus Names:CPS_2061
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
ProteomesiUP000000547: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Histidinol dehydrogenase 2UniRule annotation
PRO_0000135758Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi167879.CPS_2061.

Structurei

3D structure databases

ProteinModelPortaliQ483H8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiVAINEYW.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q483H8-1 [UniParc]FASTAAdd to Basket

« Hide

MTHKVKIHRL SDLSAEQRNK LLQRTESNLD NFIDIVKPII ENVKLNGDKA    50
LSEYAKKFDK AEVSTDQIQV TQAEFDEAFT LVDEEVIQTL SYSIDNIKKF 100
HEAQMPEEMW MKQIRPGCYA GDRFTPINAV ACYIPRGKGS FPSVAIMTAV 150
PAIVAGVPTA IIITPPGTDG KVDAATLVVA KLVGIDKVFK CGGAQGIAAV 200
AYGTNTVPKC DKVVGPGSPF VVAAKKLLAD IIHPGTPAGP SEAIVLADDT 250
ANPKLAALDL LVEAEHGPDS SAFLVTNSKE LAEQAQVAIN EYWQHMDRLR 300
VDFSSTVLSG DNGGIVLTST FEEAVDFCND YAAEHLLILS KSPFDHLGKI 350
INAGEILLGE NTPISIANYT LGPNAVLPTS MAAKTASPLS VFDYLKSCSI 400
GYLTREGYEE LAPHTYRFAK YEGFDAHANA VSHLRDEAIK SEKKIK 446
Length:446
Mass (Da):48,236
Last modified:September 13, 2005 - v1
Checksum:i4B8C883BF8A096FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ25938.1.
RefSeqiYP_268789.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ25938; AAZ25938; CPS_2061.
GeneIDi3520186.
KEGGicps:CPS_2061.
PATRICi21467245. VBIColPsy94388_1863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000083 Genomic DNA. Translation: AAZ25938.1 .
RefSeqi YP_268789.1. NC_003910.7.

3D structure databases

ProteinModelPortali Q483H8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 167879.CPS_2061.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ25938 ; AAZ25938 ; CPS_2061 .
GeneIDi 3520186.
KEGGi cps:CPS_2061.
PATRICi 21467245. VBIColPsy94388_1863.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi VAINEYW.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci CPSY167879:GI48-2061-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 34H / ATCC BAA-681.

Entry informationi

Entry nameiHISX2_COLP3
AccessioniPrimary (citable) accession number: Q483H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: September 13, 2005
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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