ID   G3P_HALVA               Reviewed;         335 AA.
AC   Q48335;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Glyceraldehyde-3-phosphate dehydrogenase;
DE            EC=1.2.1.59;
DE   AltName: Full=NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase;
DE            Short=GAPDH;
GN   Name=gap;
OS   Haloarcula vallismortis.
OC   Archaea; Euryarchaeota; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Haloarcula.
OX   NCBI_TaxID=28442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29715 / DSM 3756 / IFO 14741 / JCM 8877 / NCMB 2082;
RX   MEDLINE=96197399; PubMed=8616244; DOI=10.1007/BF00017803;
RA   Brinkmann H., Martin W.;
RT   "Higher-plant chloroplast and cytosolic 3-phosphoglycerate kinases: a
RT   case of endosymbiotic gene replacement.";
RL   Plant Mol. Biol. 30:65-75(1996).
CC   -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate + phosphate +
CC       NAD(P)(+) = 3-phospho-D-glyceroyl phosphate + NAD(P)H.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 1/5.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the glyceraldehyde-3-phosphate
CC       dehydrogenase family.
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DR   EMBL; L47295; AAB03730.1; -; Genomic_DNA.
DR   PIR; S65043; S65043.
DR   HSSP; P00362; 1NQO.
DR   BRENDA; 1.2.1.59; 1237.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043891; F:glyceraldehyde-3-phosphate dehydrogenase (N...; IEA:EC.
DR   GO; GO:0004365; F:glyceraldehyde-3-phosphate dehydrogenase (p...; IEA:InterPro.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000173; GlycerAld_3-P_DH.
DR   InterPro; IPR006424; Glyceraldehyde-3-P_DH_1.
DR   PANTHER; PTHR10836; GAP_DH; 1.
DR   Pfam; PF02800; Gp_dh_C; 1.
DR   Pfam; PF00044; Gp_dh_N; 1.
DR   PIRSF; PIRSF000149; GAP_DH; 1.
DR   PRINTS; PR00078; G3PDHDRGNASE.
DR   TIGRFAMs; TIGR01534; GAPDH-I; 1.
DR   PROSITE; PS00071; GAPDH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Glycolysis; NAD; NADP; Oxidoreductase.
FT   CHAIN         1    335       Glyceraldehyde-3-phosphate dehydrogenase.
FT                                /FTId=PRO_0000145739.
FT   NP_BIND      15     16       NAD (By similarity).
FT   REGION      155    157       Glyceraldehyde 3-phosphate binding (By
FT                                similarity).
FT   REGION      214    215       Glyceraldehyde 3-phosphate binding (By
FT                                similarity).
FT   ACT_SITE    156    156       Nucleophile (By similarity).
FT   BINDING      37     37       NAD (By similarity).
FT   BINDING     186    186       Glyceraldehyde 3-phosphate (By
FT                                similarity).
FT   BINDING     201    201       Glyceraldehyde 3-phosphate (By
FT                                similarity).
FT   BINDING     237    237       Glyceraldehyde 3-phosphate (By
FT                                similarity).
FT   BINDING     301    301       NAD; via carbonyl oxygen (By similarity).
FT   BINDING     318    318       NAD (By similarity).
SQ   SEQUENCE   335 AA;  35941 MW;  F25BF308255E03BB CRC64;
     MMSEPVRVGL NGFGRIGRNV FRASLHSDDV EIVGINDVMD DSEIDYFAQY DSVMGELEGA
     SVDDGVLTVD GTDFEAGIFH ETDPTQLPWD DLDVDVAFEA TGIFRTKEDA SQHLDAGADK
     VLISAPPKGD EPVKQLVYGV NHDEYDGEDV VSNASCTTNS ITPVAKVLDE EFGINAGQLT
     TVHAYTGSQN LMDGPNGKPR RRRAAAENII PTSTGAAQAA TEVLPELEGK LDGMAIRVPV
     PNGSITEFVV DLDDDVTESD VNAAFEDAAA GELEGVLGVT SDDVVSSDIL GDPYSTQVDL
     QSTNVVSGMT KILTWYDNEY GFSNRMLDVA EYITE
//