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Protein

Cell division protein FtsZ 1

Gene

ftsZ1

Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells (By similarity). Binds GTP and shows GTPase activity, but only at high salt (2 M KCl) concentrations.UniRule annotation1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei177 – 1771GTPUniRule annotation
Binding sitei181 – 1811GTPUniRule annotation
Binding sitei224 – 2241GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 635GTPUniRule annotation
Nucleotide bindingi146 – 1483GTPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHVOL309800:GCOK-720-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZ 1UniRule annotation
Gene namesi
Name:ftsZ1UniRule annotation
Ordered Locus Names:HVO_0717
OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Taxonomic identifieri309800 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloferax
Proteomesi
  • UP000008243 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation1 Publication

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Cell division protein FtsZ 1PRO_0000114400Add
BLAST

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi309800.HVO_0717.

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201. Archaea.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiIWGTSVD.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48327-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSIVGDAID EAEAEDMGDE SAQVDGAANI NRSGTMTDDE LKAVLKDLQT
60 70 80 90 100
NITVVGCGGA GGNTVNRMHE EGIKGAKLVA ANTDVQHLVE IGADTKILMG
110 120 130 140 150
EQKTQGRGAG SLPQVGEEAA LESQEEIYDA IEGSDMVFVT AGLGGGTGTG
160 170 180 190 200
SAPVVAKAAR ESGALTIAIV TTPFTAEGEV RRTNAEAGLE RLRDVSDTVI
210 220 230 240 250
VVPNDRLLDA VGKLPVRQAF KVSDEVLMRS VKGITELITK PGLVNLDFAD
260 270 280 290 300
VKTVMERGGV AMIGLGESDS ESKAQESVKS ALRSPLLDVD ISGANSALVN
310 320 330 340 350
VTGGSDMSIE EAEGVVEEIY DRIDPDARII WGTSVDDELE GMMRTMIVVT
360 370
GVESPQIYGR NGEAQAHAEE RLEDIDYVE
Length:379
Mass (Da):39,805
Last modified:September 21, 2011 - v2
Checksum:iBFDEFBDDFE8D0739
GO

Sequence cautioni

The sequence AAC44231 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37584 Genomic DNA. Translation: AAC44231.1. Different initiation.
CP001956 Genomic DNA. Translation: ADE02725.1.
RefSeqiWP_004044220.1. NZ_AOHU01000097.1.

Genome annotation databases

EnsemblBacteriaiADE02725; ADE02725; HVO_0717.
GeneIDi8925073.
KEGGihvo:HVO_0717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37584 Genomic DNA. Translation: AAC44231.1. Different initiation.
CP001956 Genomic DNA. Translation: ADE02725.1.
RefSeqiWP_004044220.1. NZ_AOHU01000097.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi309800.HVO_0717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADE02725; ADE02725; HVO_0717.
GeneIDi8925073.
KEGGihvo:HVO_0717.

Phylogenomic databases

eggNOGiarCOG02201. Archaea.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiIWGTSVD.

Enzyme and pathway databases

BioCyciHVOL309800:GCOK-720-MONOMER.

Family and domain databases

Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSZ1_HALVD
AccessioniPrimary (citable) accession number: Q48327
Secondary accession number(s): D4GT76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 21, 2011
Last modified: July 6, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1, Met-36 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.