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Protein

Cell division protein FtsZ 1

Gene

ftsZ1

Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells (By similarity). Binds GTP and shows GTPase activity, but only at high salt (2 M KCl) concentrations.UniRule annotation1 Publication

Caution

It is uncertain whether Met-1, Met-36 is the initiator.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei177GTPUniRule annotation1
Binding sitei181GTPUniRule annotation1
Binding sitei224GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 63GTPUniRule annotation5
Nucleotide bindingi146 – 148GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Septation
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZ 1UniRule annotation
Gene namesi
Name:ftsZ1UniRule annotation
Ordered Locus Names:HVO_0717
OrganismiHaloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
Taxonomic identifieri309800 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHaloferax
Proteomesi
  • UP000008243 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation1 Publication
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001144001 – 379Cell division protein FtsZ 1Add BLAST379

Proteomic databases

PRIDEiQ48327

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi309800.HVO_0717

Structurei

3D structure databases

SMRiQ48327
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02201 Archaea
COG0206 LUCA
HOGENOMiHOG000049094
KOiK03531
OMAiMRAVKGI
OrthoDBiPOG093Z0942

Family and domain databases

CDDicd02201 FtsZ_type1, 1 hit
Gene3Di3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
HAMAPiMF_00909 FtsZ, 1 hit
InterProiView protein in InterPro
IPR000158 Cell_div_FtsZ
IPR020805 Cell_div_FtsZ_CS
IPR024757 FtsZ_C
IPR008280 Tub_FtsZ_C
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR003008 Tubulin_FtsZ_GTPase
PfamiView protein in Pfam
PF12327 FtsZ_C, 1 hit
PF00091 Tubulin, 1 hit
PRINTSiPR00423 CELLDVISFTSZ
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
TIGRFAMsiTIGR00065 ftsZ, 1 hit
PROSITEiView protein in PROSITE
PS01134 FTSZ_1, 1 hit
PS01135 FTSZ_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q48327-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSIVGDAID EAEAEDMGDE SAQVDGAANI NRSGTMTDDE LKAVLKDLQT
60 70 80 90 100
NITVVGCGGA GGNTVNRMHE EGIKGAKLVA ANTDVQHLVE IGADTKILMG
110 120 130 140 150
EQKTQGRGAG SLPQVGEEAA LESQEEIYDA IEGSDMVFVT AGLGGGTGTG
160 170 180 190 200
SAPVVAKAAR ESGALTIAIV TTPFTAEGEV RRTNAEAGLE RLRDVSDTVI
210 220 230 240 250
VVPNDRLLDA VGKLPVRQAF KVSDEVLMRS VKGITELITK PGLVNLDFAD
260 270 280 290 300
VKTVMERGGV AMIGLGESDS ESKAQESVKS ALRSPLLDVD ISGANSALVN
310 320 330 340 350
VTGGSDMSIE EAEGVVEEIY DRIDPDARII WGTSVDDELE GMMRTMIVVT
360 370
GVESPQIYGR NGEAQAHAEE RLEDIDYVE
Length:379
Mass (Da):39,805
Last modified:September 21, 2011 - v2
Checksum:iBFDEFBDDFE8D0739
GO

Sequence cautioni

The sequence AAC44231 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37584 Genomic DNA Translation: AAC44231.1 Different initiation.
CP001956 Genomic DNA Translation: ADE02725.1
RefSeqiWP_004044220.1, NZ_AOHU01000097.1

Genome annotation databases

EnsemblBacteriaiADE02725; ADE02725; HVO_0717
GeneIDi8925073
KEGGihvo:HVO_0717

Similar proteinsi

Entry informationi

Entry nameiFTSZ1_HALVD
AccessioniPrimary (citable) accession number: Q48327
Secondary accession number(s): D4GT76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 21, 2011
Last modified: May 23, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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