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Protein

Dimethylamine dehydrogenase

Gene

dmd

Organism
Hyphomicrobium sp. (strain x)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Dimethylamine + H2O + electron-transferring flavoprotein = methylamine + formaldehyde + reduced electron-transferring flavoprotein.

Cofactori

Protein has several cofactor binding sites:
  • FMNBy similarityNote: Binds 1 FMN covalently per subunit.By similarity
  • [4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei181Proton donorBy similarity1
Binding sitei229FMNBy similarity1
Binding sitei329FMNBy similarity1
Metal bindingi352Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi355Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi358Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi371Iron-sulfur (4Fe-4S)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi398 – 427ADPBy similarityAdd BLAST30

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Flavoprotein, FMN, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16115.

Names & Taxonomyi

Protein namesi
Recommended name:
Dimethylamine dehydrogenase (EC:1.5.8.1)
Short name:
DMADh
Gene namesi
Name:dmd
OrganismiHyphomicrobium sp. (strain x)
Taxonomic identifieri79673 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaeHyphomicrobium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001944712 – 736Dimethylamine dehydrogenaseAdd BLAST735

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31S-6-FMN cysteineBy similarity1

Structurei

3D structure databases

ProteinModelPortaliQ48303.
SMRiQ48303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni176 – 179Substrate-bindingBy similarity4

Sequence similaritiesi

In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.Curated

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR023753. FAD/NAD-binding_dom.
IPR001155. OxRdtase_FMN_N.
PfamiView protein in Pfam
PF00724. Oxidored_FMN. 1 hit.
PF07992. Pyr_redox_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q48303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARDPRFDIL FTPLKLGSKT IRNRFYQVPH CNGAGTNSPG MNMAHRGIKA
60 70 80 90 100
EGGWGAVNTE QCSIHPECDD TLRITARIWD QGDMRNLRAM VDHVHSHGSL
110 120 130 140 150
AGCELFYGGP HAPAIESRTI SRGPSQYNSE FATVPGCPGF TYNHEADIDE
160 170 180 190 200
LERLQQQYVD AALRARDTGF DLVNVYGAHA YGPMQWLNPY YNRRTDKYGG
210 220 230 240 250
SFDNRARFWI ETLEKIRRAV NDDVALVTRC ATDTLYGTKG VELTEDGLRF
260 270 280 290 300
IELASPYLDL WDVNIGDIAE WGEDAGPSRF YPIAHENDWI RHIKQATNKP
310 320 330 340 350
VVGVGRYYDP EKMLQVIKAG IIDIIGAARP SIADPWLPRK IDEGRVDDIR
360 370 380 390 400
TCIGCNVCIS RWEMGGVPFI CTQNATAGEE YRRGWHPEKF EPKKSDHDVL
410 420 430 440 450
IVGAGPAGSE CARVLMERGY TVHLVDTREK TGGYVNDVAT LPGLGEWSFH
460 470 480 490 500
RDYRQTQLEK LLKKNPECQI ALKQKPMTAD DILQYGASRV VIATGAKWST
510 520 530 540 550
TGVNHRTHEP IPGADASLPH VLTPEQVYEG KKAVGKRVMI INYDAYYTAP
560 570 580 590 600
SLAEKFARAG HDVTVATVCG LGAYMEYTLE GANMQRLIHE LGIKVLGETG
610 620 630 640 650
CSRVEQGRVE LFNIWGEGYK RSYKGAGQLP RNENTSHEWH ECDTVILVTS
660 670 680 690 700
RRSEDTLYRE LKARKGEWEA NGITNVFVIG DAESPRIIAD ATFDGHRLAR
710 720 730
EIEDADPQHQ KPYKREQRAW GTAYNPDENP DLVWRV
Length:736
Mass (Da):82,655
Last modified:January 23, 2007 - v3
Checksum:iA3EE943F5617851B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89575 Genomic DNA. Translation: CAA61752.1.

Similar proteinsi

Entry informationi

Entry nameiDHDM_HYPSX
AccessioniPrimary (citable) accession number: Q48303
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 84 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families