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Reviewed, UniProtKB/Swiss-Prot Q48296 (OTCC_HALSA)

Last modified February 9, 2010. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ornithine carbamoyltransferase, catabolic
      Short name=OTCase
    EC=2.1.3.3
Gene names
Name: arcB
Synonyms: argB
Ordered Locus Names: VNG_6315G
Encoded onPlasmid pNRC200 Ref.3
OrganismHalobacterium salinarium (Halobacterium halobium) [Complete proteome] [HAMAP]
Taxonomic identifier2242 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalobacterium

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subunit structure

Homohexamer. HAMAP MF_01109

Subcellular location

Cytoplasm Probable HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Direct protein sequencing
Plasmid
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Ornithine carbamoyltransferase, catabolic HAMAP MF_01109
PRO_0000113063

Regions

Region49 – 535Carbamoyl phosphate binding By similarity
Region252 – 2554Ornithine binding By similarity

Sites

Binding site1001Carbamoyl phosphate By similarity
Binding site1271Carbamoyl phosphate By similarity
Site261Important for structural integrity By similarity
Site1401Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q48296-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BFF6E002AC0289A2

FASTA29532,676
        10         20         30         40         50         60 
MEHLVDINDV ESEEIEQLLD LAASMKENPG EFSGVMDNKS LVMLFAKPST RTRLSFETGM 

        70         80         90        100        110        120 
TQLGGHGIFF EMGSSQLSRG EPISDVSQVM SRYEDAIMAR LFEHDEMMEL AENADVPVVN 

       130        140        150        160        170        180 
GLTDFLHPCQ ALTDMFTMQE KDRLDTLAFV GDGNNVAHSL MQASAKMGVD CRIATPEGME 

       190        200        210        220        230        240 
PDEEIQDRVS DANVTVTNDP YEAVDGATAV YGDVFVSMGE EEQREEKLAE FDGFQIDQDL 

       250        260        270        280        290 
MDAARDDAIF MHCLPAHRGE EVTAEVADGP QSVIFDQAEN RMHVQKAIVH TLVNQ 

« Hide

References

« Hide 'large scale' references
[1]"Catabolic ornithine transcarbamylase of Halobacterium halobium (salinarium): purification, characterization, sequence determination, and evolution."
Ruepp A., Mueller H., Lottspeich F., Soppa J.
J. Bacteriol. 177:1129-1136(1995) [PubMed: 7868583] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
Strain: L33.
[2]"Fermentative arginine degradation in Halobacterium salinarium (formerly Halobacterium halobium): genes, gene products, and transcripts of the arcRACB gene cluster."
Ruepp A., Soppa J.
J. Bacteriol. 178:4942-4947(1996) [PubMed: 8759859] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: L33.
[3]"Genome sequence of Halobacterium species NRC-1."
Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D., Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D., Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K. expand/collapse author list , Cruz R., Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P., Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M., Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J., Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L., DasSarma S.
Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000) [PubMed: 11016950] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700922 / JCM 11081 / NRC-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X81712 Genomic DNA. Translation: CAA57356.1.
X80931 Genomic DNA. Translation: CAA56906.1.
AE004438 Genomic DNA. Translation: AAG20946.1.
PIRS49261.
RefSeqNP_395811.1.

3D structure databases

SMRQ48296. Positions 2-293.
ModBaseSearch...

Genome annotation databases

GeneID1449194.
GenomeReviewsGene locus VNG_6315G in contig AE004438_GR.
KEGGhal:VNG6315G.
NMPDRfig|64091.1.peg.2495.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG579429.
OMATVAMIFS.

Enzyme and pathway databases

BioCycHSP64091:VNG6315G-MONOMER.
MetaCyc:MONOMER-662.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P_bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn_bd.
IPR002292. Orn_carbamltrans.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
TIGRFAMsTIGR00658. orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTCC_HALSA
AccessionPrimary (citable) accession number: Q48296
Secondary accession number(s): Q59454, Q9HHN0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents