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Q48271 (COPP_HELPY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
COP-associated protein
Alternative name(s):
Copper ion-binding protein
Gene names
Name:copP
Ordered Locus Names:HP_1073
OrganismHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) [Reference proteome] [HAMAP]
Taxonomic identifier85962 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Protein attributes

Sequence length66 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of a cation-transporting system which is associated with copper export out of the H.pylori cells.

Miscellaneous

Copper (2+) binding can oxidyze the Cys residues at the metal-binding site, leading to the formation of a disulfide bond.

Sequence similarities

Contains 1 HMA domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

rplNP560393EBI-7497456,EBI-7497678

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6666COP-associated protein
PRO_0000079246

Regions

Domain2 – 6665HMA

Sites

Metal binding121Copper
Metal binding151Copper

Amino acid modifications

Disulfide bond12 ↔ 15Alternate Ref.5

Natural variations

Natural variant31A → V in strain: A68, NCTC 11638 and NCTC 11639.
Natural variant131N → D in strain: NCTC 11638.
Natural variant131N → S in strain: NCTC 11639.
Natural variant341V → A in strain: A68, NCTC 11638 and NCTC 11639.
Natural variant351S → N in strain: NCTC 11639.
Natural variant661V → I in strain: A68, NCTC 11638 and NCTC 11639.

Secondary structure

........... 66
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q48271 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 353E2C3D392816F1

FASTA667,196
        10         20         30         40         50         60 
MKATFQVPSI TCNHCVDKIE KFVGEIEGVS FIDVSVEKKS VVVEFDAPAT QDLIKEALLD 


AGQEVV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and membrane topology of a P type ATPase from Helicobacter pylori."
Melchers K., Weitzenegger T., Buhmann A., Steinhilber W., Sachs G., Schaefer K.P.
J. Biol. Chem. 271:446-457(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: A68.
[2]"Nucleotide sequence and mutational analysis indicate that two Helicobacter pylori genes encode a P-type ATPase and a cation-binding protein associated with copper transport."
Ge Z., Hiratsuka K., Taylor D.E.
Mol. Microbiol. 15:97-106(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 43629 / JCM 7656 / NCTC 11639 / UA802.
[3]"Identification and characterization of an operon of Helicobacter pylori that is involved in motility and stress adaptation."
Beier D., Spohn G., Rappuoli R., Scarlato V.
J. Bacteriol. 179:4676-4683(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 4867 / CCUG 17874 / NCTC 11638.
[4]"The complete genome sequence of the gastric pathogen Helicobacter pylori."
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. expand/collapse author list , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.
Nature 388:539-547(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700392 / 26695.
[5]"Structural insight into the distinct properties of copper transport by the Helicobacter pylori CopP protein."
Park S.J., Jung Y.-S., Kim J.-S., Seo M.-D., Lee B.J.
Proteins 71:1007-1019(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR IN COMPLEX WITH COPPER IONS, DISULFIDE BOND.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59625 Genomic DNA. Translation: AAB05476.1.
U97567 Genomic DNA. Translation: AAB66381.1.
L33259 Genomic DNA. Translation: AAB67321.1.
AE000511 Genomic DNA. Translation: AAD08120.1.
PIRA64654.
RefSeqNP_207864.1. NC_000915.1.
YP_006934989.1. NC_018939.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1YG0NMR-A1-66[»]
ProteinModelPortalQ48271.
SMRQ48271. Positions 1-66.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-3638N.
IntActQ48271. 4 interactions.
MINTMINT-161359.
STRING85962.HP1073.

Proteomic databases

PRIDEQ48271.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAD08120; AAD08120; HP_1073.
GeneID899609.
KEGGheo:C694_05545.
hpy:HP1073.
PATRIC20593485. VBIHelPyl33062_1122.

Phylogenomic databases

eggNOGCOG2608.
OMAMKVTFQV.
OrthoDBEOG6742RM.

Enzyme and pathway databases

BioCycHPY:HP1073-MONOMER.

Family and domain databases

InterProIPR000428. Cu-bd.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view]
PfamPF00403. HMA. 1 hit.
[Graphical view]
PRINTSPR00944. CUEXPORT.
SUPFAMSSF55008. SSF55008. 1 hit.
TIGRFAMsTIGR00003. TIGR00003. 1 hit.
PROSITEPS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ48271.

Entry information

Entry nameCOPP_HELPY
AccessionPrimary (citable) accession number: Q48271
Secondary accession number(s): O07682, Q48257
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Helicobacter pylori

Helicobacter pylori (strain 26695): entries and gene names