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Q48271

- COPP_HELPY

UniProt

Q48271 - COPP_HELPY

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Protein
COP-associated protein
Gene
copP, HP_1073
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Part of a cation-transporting system which is associated with copper export out of the H.pylori cells.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121Copper
Metal bindingi15 – 151Copper

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. copper ion transport Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciHPY:HP1073-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
COP-associated protein
Alternative name(s):
Copper ion-binding protein
Gene namesi
Name:copP
Ordered Locus Names:HP_1073
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000000429: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666COP-associated protein
PRO_0000079246Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi12 ↔ 15Alternate1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ48271.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rplNP560393EBI-7497456,EBI-7497678

Protein-protein interaction databases

DIPiDIP-3638N.
IntActiQ48271. 4 interactions.
MINTiMINT-161359.
STRINGi85962.HP1073.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 54
Helixi14 – 2310
Beta strandi26 – 3510
Turni36 – 394
Beta strandi40 – 456
Helixi51 – 6111

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YG0NMR-A1-66[»]
ProteinModelPortaliQ48271.
SMRiQ48271. Positions 1-66.

Miscellaneous databases

EvolutionaryTraceiQ48271.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 6665HMA
Add
BLAST

Sequence similaritiesi

Contains 1 HMA domain.

Phylogenomic databases

eggNOGiCOG2608.
OMAiMKVTFQV.
OrthoDBiEOG6742RM.

Family and domain databases

InterProiIPR000428. Cu-bd.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view]
PfamiPF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00944. CUEXPORT.
SUPFAMiSSF55008. SSF55008. 1 hit.
TIGRFAMsiTIGR00003. TIGR00003. 1 hit.
PROSITEiPS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48271-1 [UniParc]FASTAAdd to Basket

« Hide

MKATFQVPSI TCNHCVDKIE KFVGEIEGVS FIDVSVEKKS VVVEFDAPAT   50
QDLIKEALLD AGQEVV 66
Length:66
Mass (Da):7,196
Last modified:November 1, 1997 - v2
Checksum:i353E2C3D392816F1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31A → V in strain: A68, NCTC 11638 and NCTC 11639.
Natural varianti13 – 131N → D in strain: NCTC 11638.
Natural varianti13 – 131N → S in strain: NCTC 11639.
Natural varianti34 – 341V → A in strain: A68, NCTC 11638 and NCTC 11639.
Natural varianti35 – 351S → N in strain: NCTC 11639.
Natural varianti66 – 661V → I in strain: A68, NCTC 11638 and NCTC 11639.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59625 Genomic DNA. Translation: AAB05476.1.
U97567 Genomic DNA. Translation: AAB66381.1.
L33259 Genomic DNA. Translation: AAB67321.1.
AE000511 Genomic DNA. Translation: AAD08120.1.
PIRiA64654.
RefSeqiNP_207864.1. NC_000915.1.
YP_006934989.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08120; AAD08120; HP_1073.
GeneIDi13870267.
899609.
KEGGiheo:C694_05545.
hpy:HP1073.
PATRICi20593485. VBIHelPyl33062_1122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59625 Genomic DNA. Translation: AAB05476.1 .
U97567 Genomic DNA. Translation: AAB66381.1 .
L33259 Genomic DNA. Translation: AAB67321.1 .
AE000511 Genomic DNA. Translation: AAD08120.1 .
PIRi A64654.
RefSeqi NP_207864.1. NC_000915.1.
YP_006934989.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YG0 NMR - A 1-66 [» ]
ProteinModelPortali Q48271.
SMRi Q48271. Positions 1-66.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-3638N.
IntActi Q48271. 4 interactions.
MINTi MINT-161359.
STRINGi 85962.HP1073.

Proteomic databases

PRIDEi Q48271.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD08120 ; AAD08120 ; HP_1073 .
GeneIDi 13870267.
899609.
KEGGi heo:C694_05545.
hpy:HP1073.
PATRICi 20593485. VBIHelPyl33062_1122.

Phylogenomic databases

eggNOGi COG2608.
OMAi MKVTFQV.
OrthoDBi EOG6742RM.

Enzyme and pathway databases

BioCyci HPY:HP1073-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q48271.

Family and domain databases

InterProi IPR000428. Cu-bd.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view ]
Pfami PF00403. HMA. 1 hit.
[Graphical view ]
PRINTSi PR00944. CUEXPORT.
SUPFAMi SSF55008. SSF55008. 1 hit.
TIGRFAMsi TIGR00003. TIGR00003. 1 hit.
PROSITEi PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and membrane topology of a P type ATPase from Helicobacter pylori."
    Melchers K., Weitzenegger T., Buhmann A., Steinhilber W., Sachs G., Schaefer K.P.
    J. Biol. Chem. 271:446-457(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A68.
  2. "Nucleotide sequence and mutational analysis indicate that two Helicobacter pylori genes encode a P-type ATPase and a cation-binding protein associated with copper transport."
    Ge Z., Hiratsuka K., Taylor D.E.
    Mol. Microbiol. 15:97-106(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43629 / JCM 7656 / NCTC 11639 / UA802.
  3. "Identification and characterization of an operon of Helicobacter pylori that is involved in motility and stress adaptation."
    Beier D., Spohn G., Rappuoli R., Scarlato V.
    J. Bacteriol. 179:4676-4683(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 4867 / CCUG 17874 / NCTC 11638.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700392 / 26695.
  5. "Structural insight into the distinct properties of copper transport by the Helicobacter pylori CopP protein."
    Park S.J., Jung Y.-S., Kim J.-S., Seo M.-D., Lee B.J.
    Proteins 71:1007-1019(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR IN COMPLEX WITH COPPER IONS, DISULFIDE BOND.

Entry informationi

Entry nameiCOPP_HELPY
AccessioniPrimary (citable) accession number: Q48271
Secondary accession number(s): O07682, Q48257
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Copper (2+) binding can oxidyze the Cys residues at the metal-binding site, leading to the formation of a disulfide bond.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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