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Protein

3-dehydroquinate dehydratase

Gene

aroQ

Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a trans-dehydration via an enolate intermediate.By similarity

Catalytic activityi

3-dehydroquinate = 3-dehydroshikimate + H2O.

Pathwayi: chorismate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 3-dehydroquinate synthase (aroB)
  3. 3-dehydroquinate dehydratase (aroQ)
  4. Shikimate dehydrogenase (NADP(+)) (aroE)
  5. Shikimate kinase (aroK)
  6. 3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
  7. Chorismate synthase (aroC)
This subpathway is part of the pathway chorismate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate, the pathway chorismate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei17Transition state stabilizer1
Active sitei22Proton acceptor1
Binding sitei76Substrate1 Publication1
Binding sitei82Substrate1 Publication1
Binding sitei89Substrate1 Publication1
Active sitei102Proton donor1
Binding sitei113Substrate1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

BioCyciHPY:HP1038-MONOMER.
BRENDAi4.2.1.10. 2604.
UniPathwayiUPA00053; UER00086.

Names & Taxonomyi

Protein namesi
Recommended name:
3-dehydroquinate dehydratase (EC:4.2.1.10)
Short name:
3-dehydroquinase
Alternative name(s):
Type II DHQase
Gene namesi
Name:aroQ
Ordered Locus Names:HP_1038
OrganismiHelicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Taxonomic identifieri85962 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000000429 Componenti: Chromosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001599051 – 1673-dehydroquinate dehydrataseAdd BLAST167

Proteomic databases

PaxDbiQ48255.

Interactioni

Subunit structurei

Homododecamer.2 Publications

Protein-protein interaction databases

DIPiDIP-3328N.
IntActiQ48255. 2 interactors.
MINTiMINT-180311.
STRINGi85962.HP1038.

Chemistry databases

BindingDBiQ48255.

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 7Combined sources7
Helixi11 – 13Combined sources3
Turni14 – 16Combined sources3
Helixi20 – 22Combined sources3
Helixi27 – 40Combined sources14
Beta strandi45 – 51Combined sources7
Helixi55 – 66Combined sources12
Beta strandi67 – 69Combined sources3
Beta strandi72 – 76Combined sources5
Helixi78 – 82Combined sources5
Helixi85 – 92Combined sources8
Beta strandi94 – 96Combined sources3
Beta strandi98 – 104Combined sources7
Helixi106 – 108Combined sources3
Helixi111 – 113Combined sources3
Helixi117 – 121Combined sources5
Beta strandi122 – 129Combined sources8
Helixi132 – 152Combined sources21
Turni153 – 156Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J2YX-ray2.60A1-167[»]
2C4VX-ray2.50A1-167[»]
2C4WX-ray1.55A1-167[»]
2C57X-ray3.10A/B/C/D/E/F/G/H/I/J/K/L1-167[»]
2WKSX-ray2.95A/B/C/D/E/F1-167[»]
2XB9X-ray2.75A/B/C1-167[»]
2XD9X-ray1.95A/B/C1-167[»]
2XDAX-ray1.85A1-167[»]
4B6RX-ray2.00A/B/C1-167[»]
4B6SX-ray1.90A/B/C1-167[»]
ProteinModelPortaliQ48255.
SMRiQ48255.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ48255.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni103 – 104Substrate binding2

Sequence similaritiesi

Belongs to the type-II 3-dehydroquinase family.Curated

Phylogenomic databases

eggNOGiENOG4108Z38. Bacteria.
COG0757. LUCA.
KOiK03786.
OMAiRREPGHY.

Family and domain databases

CDDicd00466. DHQase_II. 1 hit.
Gene3Di3.40.50.9100. 1 hit.
HAMAPiMF_00169. AroQ. 1 hit.
InterProiIPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view]
PANTHERiPTHR21272. PTHR21272. 1 hit.
PfamiPF01220. DHquinase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF001399. DHquinase_II. 1 hit.
ProDomiPD004527. DHquinase_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52304. SSF52304. 1 hit.
TIGRFAMsiTIGR01088. aroQ. 1 hit.
PROSITEiPS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48255-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILVIQGPN LNMLGHRDPR LYGMVTLDQI HEIMQTFVKQ GNLDVELEFF
60 70 80 90 100
QTNFEGEIID KIQESVGSDY EGIIINPGAF SHTSIAIADA IMLAGKPVIE
110 120 130 140 150
VHLTNIQARE EFRKNSYTGA ACGGVIMGFG PLGYNMALMA MVNILAEMKA
160
FQEAQKNNPN NPINNQK
Length:167
Mass (Da):18,483
Last modified:November 1, 1997 - v2
Checksum:i1AEC60B924987F07
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156K → Q in CAA67380 (PubMed:8912695).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08081.1.
X98878 Genomic DNA. Translation: CAA67380.1.
PIRiS72447.
RefSeqiNP_207828.1. NC_000915.1.
WP_000699284.1. NC_018939.1.

Genome annotation databases

EnsemblBacteriaiAAD08081; AAD08081; HP_1038.
GeneIDi899573.
KEGGiheo:C694_05370.
hpy:HP1038.
PATRICi20593413. VBIHelPyl33062_1087.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000511 Genomic DNA. Translation: AAD08081.1.
X98878 Genomic DNA. Translation: CAA67380.1.
PIRiS72447.
RefSeqiNP_207828.1. NC_000915.1.
WP_000699284.1. NC_018939.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J2YX-ray2.60A1-167[»]
2C4VX-ray2.50A1-167[»]
2C4WX-ray1.55A1-167[»]
2C57X-ray3.10A/B/C/D/E/F/G/H/I/J/K/L1-167[»]
2WKSX-ray2.95A/B/C/D/E/F1-167[»]
2XB9X-ray2.75A/B/C1-167[»]
2XD9X-ray1.95A/B/C1-167[»]
2XDAX-ray1.85A1-167[»]
4B6RX-ray2.00A/B/C1-167[»]
4B6SX-ray1.90A/B/C1-167[»]
ProteinModelPortaliQ48255.
SMRiQ48255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-3328N.
IntActiQ48255. 2 interactors.
MINTiMINT-180311.
STRINGi85962.HP1038.

Chemistry databases

BindingDBiQ48255.
ChEMBLiCHEMBL4680.

Proteomic databases

PaxDbiQ48255.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD08081; AAD08081; HP_1038.
GeneIDi899573.
KEGGiheo:C694_05370.
hpy:HP1038.
PATRICi20593413. VBIHelPyl33062_1087.

Phylogenomic databases

eggNOGiENOG4108Z38. Bacteria.
COG0757. LUCA.
KOiK03786.
OMAiRREPGHY.

Enzyme and pathway databases

UniPathwayiUPA00053; UER00086.
BioCyciHPY:HP1038-MONOMER.
BRENDAi4.2.1.10. 2604.

Miscellaneous databases

EvolutionaryTraceiQ48255.
PROiQ48255.

Family and domain databases

CDDicd00466. DHQase_II. 1 hit.
Gene3Di3.40.50.9100. 1 hit.
HAMAPiMF_00169. AroQ. 1 hit.
InterProiIPR001874. DHquinase_II.
IPR018509. DHquinase_II_CS.
[Graphical view]
PANTHERiPTHR21272. PTHR21272. 1 hit.
PfamiPF01220. DHquinase_II. 1 hit.
[Graphical view]
PIRSFiPIRSF001399. DHquinase_II. 1 hit.
ProDomiPD004527. DHquinase_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52304. SSF52304. 1 hit.
TIGRFAMsiTIGR01088. aroQ. 1 hit.
PROSITEiPS01029. DEHYDROQUINASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAROQ_HELPY
AccessioniPrimary (citable) accession number: Q48255
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Helicobacter pylori
    Helicobacter pylori (strain 26695): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.