ID   CDH_HELPY               Reviewed;         244 AA.
AC   Q48248;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 2.
DT   16-JUN-2009, entry version 54.
DE   RecName: Full=CDP-diacylglycerol pyrophosphatase;
DE            EC=3.6.1.26;
DE   AltName: Full=CDP-diacylglycerol phosphatidylhydrolase;
DE   AltName: Full=CDP-diglyceride hydrolase;
GN   Name=cdh; OrderedLocusNames=HP_0871;
OS   Helicobacter pylori (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=210;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   MEDLINE=97394467; PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R.,
RA   Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F.,
RA   Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G.,
RA   Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D.,
RA   Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D.,
RA   Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C.,
RA   Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D.,
RA   Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-244.
RC   STRAIN=951, and DSM 4867 / CCUG 17874 / NCTC 11638;
RX   MEDLINE=95198543; PubMed=7891557;
RX   DOI=10.1111/j.1365-2958.1994.tb01307.x;
RA   O'Toole P.W., Kostrzynska M., Trust T.J.;
RT   "Non-motile mutants of Helicobacter pylori and Helicobacter mustelae
RT   defective in flagellar hook production.";
RL   Mol. Microbiol. 14:691-703(1994).
CC   -!- CATALYTIC ACTIVITY: CDP-diacylglycerol + H(2)O = CMP +
CC       phosphatidate.
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol degradation;
CC       phosphatidate from CDP-diacylglycerol: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the cdh family.
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DR   EMBL; AE000511; AAD07921.1; -; Genomic_DNA.
DR   EMBL; U09549; AAA92802.1; -; Genomic_DNA.
DR   PIR; G64628; G64628.
DR   RefSeq; NP_207665.1; -.
DR   GeneID; 899400; -.
DR   GenomeReviews; AE000511_GR; HP_0871.
DR   KEGG; hpy:HP0871; -.
DR   NMPDR; fig|85962.1.peg.862; -.
DR   TIGR; HP_0871; -.
DR   HOGENOM; Q48248; -.
DR   OMA; Q48248; EIQDHEC.
DR   BRENDA; 3.6.1.26; 1131.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008715; F:CDP-diacylglycerol diphosphatase activity; IEA:HAMAP.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00319; -; 1.
DR   InterPro; IPR003763; CDP-diacylglyc_Pase_bac.
DR   InterPro; IPR015993; CDP-diacylglyc_Pase_proteobac.
DR   Pfam; PF02611; CDH; 1.
DR   PIRSF; PIRSF001273; CDH; 1.
DR   TIGRFAMs; TIGR00672; cdh; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome; Hydrolase;
KW   Membrane; Phospholipid biosynthesis; Transmembrane.
FT   CHAIN         1    244       CDP-diacylglycerol pyrophosphatase.
FT                                /FTId=PRO_0000198577.
FT   TRANSMEM      7     23       Potential.
SQ   SEQUENCE   244 AA;  27516 MW;  0930D0B9B1377C1A CRC64;
     MKKAGFLFLA VMAIVVMSLN AKDPNVLRKI VFEKCLPNYE KNQNPSPCIE VKPDAGYVVL
     KDINGPLQYL LMPTTHISGI ESPLLLDPST PNFFYLSWQA RDFMSKKYGQ PIPDYAISLT
     INSSKGRSQN HFHIHISCIS LEARKQLDNN LKKINSRWSP LPGGLNGHKY LARRVTESEL
     VQKSPFVMLN KEVPNAYKRM GDYGLAVVQQ SDNSFVLLAT QFNPLTLNRA SAEEIQDHEC
     AILH
//