Reviewed, UniProtKB/Swiss-Prot Q48248 (CDH_HELPY)

Names and origin

Protein names

Recommended name:
    CDP-diacylglycerol pyrophosphatase
    EC=3.6.1.26
Alternative name(s):
    CDP-diacylglycerol phosphatidylhydrolase
    CDP-diglyceride hydrolase

Gene names

Name:	cdh
Ordered Locus Names:	HP_0871

Organism

Helicobacter pylori (Campylobacter pylori) [Complete proteome] [HAMAP]

Taxonomic identifier

210 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CDP-diacylglycerol + H2O = CMP + phosphatidate. HAMAP MF_00319
Pathway	Phospholipid metabolism; CDP-diacylglycerol degradation; phosphatidate from CDP-diacylglycerol: step 1/1. HAMAP MF_00319
Subcellular location	Cell inner membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the cdh family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	CDP-diacylglycerol diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	CDP-diacylglycerol pyrophosphatase HAMAP MF_00319		PRO_0000198577
Regions
	Transmembrane	7 – 23	17	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q48248-1 [UniParc]. Last modified November 1, 1998. Version 2. Checksum: 0930D0B9B1377C1A	FASTA	244	27,516
	10 20 30 40 50 60 MKKAGFLFLA VMAIVVMSLN AKDPNVLRKI VFEKCLPNYE KNQNPSPCIE VKPDAGYVVL 70 80 90 100 110 120 KDINGPLQYL LMPTTHISGI ESPLLLDPST PNFFYLSWQA RDFMSKKYGQ PIPDYAISLT 130 140 150 160 170 180 INSSKGRSQN HFHIHISCIS LEARKQLDNN LKKINSRWSP LPGGLNGHKY LARRVTESEL 190 200 210 220 230 240 VQKSPFVMLN KEVPNAYKRM GDYGLAVVQQ SDNSFVLLAT QFNPLTLNRA SAEEIQDHEC AILH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of the gastric pathogen Helicobacter pylori." Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J. , Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C. Nature 388:539-547(1997) [PubMed: 9252185] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700392 / 26695.
[2]	"Non-motile mutants of Helicobacter pylori and Helicobacter mustelae defective in flagellar hook production." O'Toole P.W., Kostrzynska M., Trust T.J. Mol. Microbiol. 14:691-703(1994) [PubMed: 7891557] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 210-244. Strain: 951 and DSM 4867 / CCUG 17874 / NCTC 11638.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000511 Genomic DNA. Translation: AAD07921.1. U09549 Genomic DNA. Translation: AAA92802.1.
PIR	G64628.
RefSeq	NP_207665.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	899400.
GenomeReviews	Gene locus HP_0871 in contig AE000511_GR.
KEGG	hpy:HP0871.
NMPDR	fig|85962.1.peg.862.
TIGR	HP_0871.
Phylogenomic databases
HOGENOM	Q48248.
OMA	Q48248. EIQDHEC.
Enzyme and pathway databases
BRENDA	3.6.1.26. 1131.
Family and domain databases
HAMAP	MF_00319. [Tree]
InterPro	IPR003763. CDP-diacylglyc_Pase_bac. IPR015993. CDP-diacylglyc_Pase_proteobac. [Graphical view]
Pfam	PF02611. CDH. 1 hit. [Graphical view]
PIRSF	PIRSF001273. CDH. 1 hit.
TIGRFAMs	TIGR00672. cdh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDH_HELPY

Accession

Primary (citable) accession number: Q48248

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)