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Protein
Submitted name:

Adhesin

Gene

hia

Organism
Haemophilus influenzae
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
AdhesinImported
Submitted name:
HiaImported
Gene namesi
Name:hiaImported
OrganismiHaemophilus influenzaeImported
Taxonomic identifieri727 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S7MX-ray2.10A/B/C/D/E/F541-706[»]
2GR7X-ray2.30A/B/C/D/E/F992-1098[»]
2GR8X-ray2.00A/B/C/D/E/F1022-1098[»]
3EMFX-ray2.00A/B/C51-166[»]
3EMIX-ray1.80A307-422[»]
3EMOX-ray3.00A/B/C937-1098[»]
SMRiQ48152. Positions 549-706, 998-1098.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 2424ESPRInterPro annotationAdd
BLAST
Domaini53 – 10452HiaBD2InterPro annotationAdd
BLAST
Domaini302 – 36867TAA-Trp-ringInterPro annotationAdd
BLAST
Domaini589 – 64153HiaBD2InterPro annotationAdd
BLAST
Domaini714 – 79481TAA-Trp-ringInterPro annotationAdd
BLAST
Domaini975 – 99622YadA_stalkInterPro annotationAdd
BLAST
Domaini1021 – 109878YadA_anchorInterPro annotationAdd
BLAST

Family and domain databases

InterProiIPR008635. Coiled_stalk_dom.
IPR024973. ESPR.
IPR029275. HiaBD2_put_GIN_domain.
IPR028230. TAA-Trp-ring.
IPR005594. YadA_C.
[Graphical view]
PfamiPF13018. ESPR. 1 hit.
PF15403. HiaBD2. 2 hits.
PF15401. TAA-Trp-ring. 2 hits.
PF03895. YadA_anchor. 1 hit.
PF05662. YadA_stalk. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q48152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKIFNVIWN VVTQTWVVVS ELTRTHTKCA SATVAVAVLA TLLSATVEAN
60 70 80 90 100
NNTPVTNKLK AYGDANFNFT NNSIADAEKQ VQEAYKGLLN LNEKNASDKL
110 120 130 140 150
LVEDNTAATV GNLRKLGWVL SSKNGTRNEK SQQVKHADEV LFEGKGGVQV
160 170 180 190 200
TSTSENGKHT ITFALAKDLG VKTATVSDTL TIGGGAAAGA TTTPKVNVTS
210 220 230 240 250
TTDGLKFAKD AAGANGDTTV HLNGIGSTLT DTLVGSPATH IDGGDQSTHY
260 270 280 290 300
TRAASIKDVL NAGWNIKGVK AGSTTGQSEN VDFVHTYDTV EFLSADTETT
310 320 330 340 350
TVTVDSKENG KRTEVKIGAK TSVIKEKDGK LFTGKANKET NKVDGANATE
360 370 380 390 400
DADEGKGLVT AKDVIDAVNK TGWRIKTTDA NGQNGDFATV ASGTNVTFAS
410 420 430 440 450
GNGTTATVTN GTDGITVKYD AKVGDGLKLD GDKIAADTTA LTVNDGKNAN
460 470 480 490 500
NPKGKVADVA STDEKKLVTA KGLVTALNSL SWTTTAAEAD GGTLDGNASE
510 520 530 540 550
QEVKAGDKVT FKAGKNLKVK QEGANFTYSL QDALTGLTSI TLGTGNNGAK
560 570 580 590 600
TEINKDGLTI TPANGAGANN ANTISVTKDG ISAGGQSVKN VVSGLKKFGD
610 620 630 640 650
ANFDPLTSSA DNLTKQNDDA YKGLTNLDEK GTDKQTPVVA DNTAATVGDL
660 670 680 690 700
RGLGWVISAD KTTGGSTEYH DQVRNANEVK FKSGNGINVS GKTVNGRREI
710 720 730 740 750
TFELAKGEVV KSNEFTVKET NGKETSLVKV GDKYYSKEDI DLTTGQPKLK
760 770 780 790 800
DGNTVAAKYQ DKGGKVVSVT DNTEATITNK GSGYVTGNQV ADAIAKSGFE
810 820 830 840 850
LGLADEADAK AAFDDKTKAL SAGTTEIVNA HDKVRFANGL NTKVSAATVE
860 870 880 890 900
STDANGDKVT TTFVKTDVEL PLTQIYNTDA NGKKITKVVK DGQTKWYELN
910 920 930 940 950
ADGTADMTKE VTLGNVDSDG KKVVKDNDGK WYHAKADGTA DKTKGEVSND
960 970 980 990 1000
KVSTDEKHVV SLDPNDQSKG KGVVIDNVAN GDISATSTDA INGSQLYAVA
1010 1020 1030 1040 1050
KGVTNLAGQV NNLEGKVNKV GKRADAGTAS ALAASQLPQA TMPGKSMVAI
1060 1070 1080 1090
AGSSYQGQNG LAIGVSRISD NGKVIIRLSG TTNSQGKTGV AAGVGYQW
Length:1,098
Mass (Da):114,015
Last modified:October 1, 2002 - v2
Checksum:i732890C422ED8C39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38617 Genomic DNA. Translation: AAC43721.2.
AY078083 Genomic DNA. Translation: AAL79949.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38617 Genomic DNA. Translation: AAC43721.2.
AY078083 Genomic DNA. Translation: AAL79949.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S7MX-ray2.10A/B/C/D/E/F541-706[»]
2GR7X-ray2.30A/B/C/D/E/F992-1098[»]
2GR8X-ray2.00A/B/C/D/E/F1022-1098[»]
3EMFX-ray2.00A/B/C51-166[»]
3EMIX-ray1.80A307-422[»]
3EMOX-ray3.00A/B/C937-1098[»]
SMRiQ48152. Positions 549-706, 998-1098.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR008635. Coiled_stalk_dom.
IPR024973. ESPR.
IPR029275. HiaBD2_put_GIN_domain.
IPR028230. TAA-Trp-ring.
IPR005594. YadA_C.
[Graphical view]
PfamiPF13018. ESPR. 1 hit.
PF15403. HiaBD2. 2 hits.
PF15401. TAA-Trp-ring. 2 hits.
PF03895. YadA_anchor. 1 hit.
PF05662. YadA_stalk. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a second family of high-molecular-weight adhesion proteins expressed by non-typable Haemophilus influenzae."
    Barenkamp S.J., St Geme J.W. 3rd
    Mol. Microbiol. 19:1215-1223(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Nontypeable strain 11Imported.
  2. "The Haemophilus influenzae Hia autotransporter harbours two adhesive pockets that reside in the passenger domain and recognize the same host cell receptor."
    Laarmann S., Cutter D., Juehne T., Barenkamp S.J., St Geme J.W.
    Mol. Microbiol. 46:731-743(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: nontypable strain 3230AImported.
  3. "Structural basis for host recognition by the Haemophilus influenzae Hia autotransporter."
    Yeo H.J., Cotter S.E., Laarmann S., Juehne T., St Geme J.W., Waksman G.
    EMBO J. 23:1245-1256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 541-706.
  4. "Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter."
    Meng G., Surana N.K., St Geme J.W., Waksman G.
    EMBO J. 25:2297-2304(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1022-1098.
  5. "Repetitive architecture of the Haemophilus influenzae Hia trimeric autotransporter."
    Meng G., St Geme J.W., Waksman G.
    J. Mol. Biol. 384:824-836(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 307-422.

Entry informationi

Entry nameiQ48152_HAEIF
AccessioniPrimary (citable) accession number: Q48152
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: October 1, 2002
Last modified: April 13, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.