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Protein

Lipid A export ATP-binding/permease protein MsbA 2

Gene

msbA2

Organism
Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi381 – 388ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbA 2UniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbA2UniRule annotation
Ordered Locus Names:CPS_2774
OrganismiColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus)
Taxonomic identifieri167879 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesColwelliaceaeColwellia
Proteomesi
  • UP000000547 Componenti: Chromosome

Subcellular locationi

Q480N3:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalUniRule annotationAdd BLAST21
Transmembranei68 – 88HelicalUniRule annotationAdd BLAST21
Transmembranei146 – 166HelicalUniRule annotationAdd BLAST21
Transmembranei167 – 187HelicalUniRule annotationAdd BLAST21
Transmembranei254 – 274HelicalUniRule annotationAdd BLAST21
Transmembranei280 – 300HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716221 – 584Lipid A export ATP-binding/permease protein MsbA 2Add BLAST584

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi167879.CPS_2774.

Structurei

3D structure databases

ProteinModelPortaliQ480N3.
SMRiQ480N3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 315ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini347 – 583ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OrthoDBiPOG091H00DB.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q480N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQVSKTIAK PSGNANLYSR LFSYYRVYKK LIFIALAGLC LFSFVDAGMI
60 70 80 90 100
YFVKPLIDQG LSKADSHTLQ LGALLVVAIF FLRGIASFTS SYAIAYISSK
110 120 130 140 150
VTYRIRQQAF DKLLYLPRTY FDLNSRGSLI SKIIYDTEQL SQSFSSAVVI
160 170 180 190 200
AIRESVIILV LFSMMVYNSW QLTAIFLVIV PIIALIINKV SKRFKNISHK
210 220 230 240 250
LQNSMGQVSN KTEQAILNQQ EIVLLDTRTQ ISAQFEKTNN NNRQQNMKLQ
260 270 280 290 300
ATSAISNPVI QLIASFAIAA VLLLASIDQV LNQLTPGSFT LILIAMGSLL
310 320 330 340 350
KPLKQLSNIN QQLQKGLIAA KSLFSFLDQQ EEHDIGTKQL SKTCSNIRFN
360 370 380 390 400
NFSFTYQGKT QPALSNFSLQ IKGGTSVAFV GESGSGKSTL ARLLLRLYQS
410 420 430 440 450
PKQSILINDI AIEDYSLSSL RAQFAFVSQD IVLIDDTLAN NISFGCNRDV
460 470 480 490 500
TDSEIEQAAI NANVMAFAKE LPLGLNSEIG ENGRNLSGGQ RQRIAIARAM
510 520 530 540 550
LRDASIIVLD EATSALDNHS EKHIQQALTR LTQHKTVLII AHKLSSIQHV
560 570 580
DEIIVINKGR LIEQGNHKTL QAKAGYYQSL YQSQ
Length:584
Mass (Da):64,771
Last modified:January 9, 2007 - v2
Checksum:iA070ECB27161D5D2
GO

Sequence cautioni

Q480N3: The sequence AAZ25842 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000083 Genomic DNA. Translation: AAZ25842.1. Different initiation.
RefSeqiWP_041737726.1. NC_003910.7.

Genome annotation databases

EnsemblBacteriaiAAZ25842; AAZ25842; CPS_2774.
KEGGicps:CPS_2774.

Similar proteinsi

Entry informationi

Entry nameiMSBA2_COLP3
AccessioniPrimary (citable) accession number: Q480N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 25, 2017
This is version 80 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families