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Q480B3 (PUR7_COLP3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6
Alternative name(s):
SAICAR synthetase
Gene names
Name:purC
Ordered Locus Names:CPS_2905
OrganismColwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) [Complete proteome] [HAMAP]
Taxonomic identifier167879 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Colwelliaceae › Colwellia

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137

Sequence similarities

Belongs to the SAICAR synthetase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpurine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
PRO_1000117829

Sequences

Sequence LengthMass (Da)Tools
Q480B3 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: D6D293336E27E443

FASTA36741,261
        10         20         30         40         50         60 
MNLADKVLAV NNDLPIRTDS PVHSGKVRSV YWLTATDSKR LIEEKGYDVP SDTSLAIMVI 

        70         80         90        100        110        120 
SDRISAFDCI WSGENDMRGV PGKGAALNAI SNHWFKMFKE QGLADSHILD IPHPFVWIVQ 

       130        140        150        160        170        180 
KAKPVMIEAI CRQYITGSMW RSYTKGERDF CGIELPEGLA KDSKLTSLLQ TPSTKGILEG 

       190        200        210        220        230        240 
IPGVPAVDDV NITRKNIEDN FEAFNFKSVD DIARYEKLLT EGFDVISTAL SKIDQVFVDT 

       250        260        270        280        290        300 
KFEFGYVKDV NGDDKLIYMD EVGTPDSSRI WDGEQYRAGK VVENSKEGFR QLLLNHFPDA 

       310        320        330        340        350        360 
DILLNKDRMS EREALARDNK LPLSVLMDVS KTYTDIAEKI TGNKIVLSDN PKAEIIAILR 


EQYQLID

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References

[1]"The psychrophilic lifestyle as revealed by the genome sequence of Colwellia psychrerythraea 34H through genomic and proteomic analyses."
Methe B.A., Nelson K.E., Deming J.W., Momen B., Melamud E., Zhang X., Moult J., Madupu R., Nelson W.C., Dodson R.J., Brinkac L.M., Daugherty S.C., Durkin A.S., DeBoy R.T., Kolonay J.F., Sullivan S.A., Zhou L., Davidsen T.M. expand/collapse author list , Wu M., Huston A.L., Lewis M., Weaver B., Weidman J.F., Khouri H., Utterback T.R., Feldblyum T.V., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 102:10913-10918(2005) [PubMed: 16043709] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 34H / ATCC BAA-681.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000083 Genomic DNA. Translation: AAZ24402.1.
RefSeqYP_269606.1. NC_003910.7.

3D structure databases

HSSPHSSP built from PDB template 2CNQ based on UniProtKB P27616.
ProteinModelPortalQ480B3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ480B3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3519186.
GenomeReviewsGene locus CPS_2905 in contig CP000083_GR.
KEGGcps:CPS_2905.
NMPDRfig|167879.3.peg.2897.
PATRIC21468835. VBIColPsy94388_2638.
TIGRCPS_2905.

Phylogenomic databases

eggNOGCOG0152.
HOGENOMHBG555040.
OMASSRIWDG.
ProtClustDBPRK13960.

Enzyme and pathway databases

BioCycCPSY167879:CPS_2905-MONOMER.

Family and domain databases

HAMAPMF_00137. SAICAR_synth.
[Tree]
InterProIPR013816. ATP_grasp_subdomain_2.
IPR014106. PurC_vibrio.
IPR001636. SAICAR_synth.
[Graphical view]
Gene3DG3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KOK01923.
PANTHERPTHR11609. SAICAR_synt. 1 hit.
PfamPF01259. SAICAR_synt. 1 hit.
[Graphical view]
TIGRFAMsTIGR02735. PurC_vibrio. 1 hit.
PROSITEPS01057. SAICAR_SYNTHETASE_1. False negative.
PS01058. SAICAR_SYNTHETASE_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR7_COLP3
AccessionPrimary (citable) accession number: Q480B3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 13, 2005
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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